<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22205

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPVGGPTSAPQPPPAAPATQGVKLSVLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYLPAKCLTLAVWNQQVLGRKTGTASVHKVSIKIDETDGSKPLQISHEPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNSASHPVGSLSKHRLFIKLTRLPQYYIVVEMFDVANSSTELQYKYYFLSVSQLEGEDGLPCALLLQQFKPNLEELVQDLSSGRMLRPGTKRKLSGEQGATEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKGVSEETRKALDRTLLDCTFRLQGRNNRTWVAELVFTSCPLNSTSTKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLDFSRALPEMPSFLSLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCHSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLSMFVDSNQDARRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCVVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEQNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPEQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPARPGECTIFASVHELMANLTLNSGGRP
Length1431
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.06
Grand average of hydropathy-0.166
Instability index51.92
Isoelectric point8.62
Molecular weight158756.72
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22205
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     291.88|      57|      58|     995|    1051|       1
---------------------------------------------------------------------------
  940-  988 (30.55/ 9.99)	.......................PAP.GLKTFLS......M.....FVDSNQDARRRsvneddnpPSPVGvdvmdtlmPH..MQPQ
  993- 1049 (110.96/56.96)	G.QGVYP..PLTSPPNSYHGNVAPSP.SMMPTQSPGN..IH.....AANSPSGALRA........PSPFG........PT..PSPS
 1050- 1080 (55.47/24.55)	S.LGI......................SM......GQ..TS.....NFASPHGALDP........SSPY.........PM..VSPS
 1081- 1139 (56.79/25.32)	QrTGTWPgsPQVS.........GPSPgARIHGMSPGNpsLHspipdASHSPRAG..T........SSQVM........PTsmPPPR
 1145- 1174 (38.11/14.41)	S.WAASI..PTILTHNALHVLLLPSP.TMCVV..PG..................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.69|      48|     255|     492|     583|       5
---------------------------------------------------------------------------
  505-  557 (72.55/106.84)	LHLSNSASHPVGSLSKHRLFIK.LTRLPQYYIVVemFDVANSSTELQykyYFLS
  732-  780 (82.14/32.51)	LTYENPLSEPVGGRKVVEMFLNdWNSISQLYECV..LDFSRALPEMP...SFLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.43|      48|     650|     613|     674|       8
---------------------------------------------------------------------------
  613-  674 (69.88/70.35)	PKRSGEMCAFNKELAhlvamCDTNMpligLRSELSNMEI...PHQGVQVEGDgcshaIRL.LRVPP
 1271- 1322 (77.55/44.67)	PFKYNTLNAFTKLLG.....APTNI....LRDCVRIMKLelfPEQAAQLKWN.....VQFcLTIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.39|      61|     149|     280|     341|       9
---------------------------------------------------------------------------
  280-  341 (103.53/65.18)	CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYLPAKCLTLAVWNQQV...LGRKTGTASVHK
  431-  496 (100.86/59.54)	CGRSECLHIFVD.LHSGMFqpMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLkfwLGEQRCRQSVKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.38|      34|     491|     852|     887|      10
---------------------------------------------------------------------------
  852-  887 (55.23/44.53)	QLLQVLSDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQ
 1346- 1381 (53.15/35.78)	QLTQRLPVPQEPISII..VPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.75|      13|     145|      24|      39|      12
---------------------------------------------------------------------------
   24-   36 (25.52/19.62)	PPPAAPATQGVKL
 1325- 1337 (25.23/ 9.79)	PPIAPPGTIAVVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22205 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWA
955
1147










Molecular Recognition Features






MoRF SequenceStartStop




NANANA