<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22203

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEVVYVCEWEKRPKNNHCPSIPLVCAWSCRNLIAFTTDLKNEEDDKELSHMIHIIDTEHPWDVYSINSGHREVISCLEWDQSGSRLLSADGDGEIKCWAMKEHLVNSWESIQSSSVDGDPIVALSWLHNGVKLALHVEKSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPNGALLSASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVCVSVVNEKCRIDTELLPSLFMRCTTDPVRRDKYPAVTHLKFLTRENSEQVLLCASSQMGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPMILKWRILSATNDLDRVSAVALPKLPISISNTDLKVASDTKFCPGLGLALSFHDGSIQILHRLSLHTMGMFYGSSGSSQRVGDEPAIKRQRAGGPAVHFKALQFSWTSLALVGVDNHGKLHMIRVSPSMGQLLDMNTLLRHLLFLLEYCMVTGYDWWDVLLHVQPGMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSSATAARANDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLAEICTKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSIVRPGFGFLRDGPSLGMLREMMVMIRIWGLLKPGCLPIYTATSDNQDSMSLLFRLLTKLWLCSRDESHPQEPDETLLDECCLLPSQLLVPSMDWLPINDGVITKIQSKHQLRLQFGKPYTLPGLNPNSQMEIFSRSPASQRMDNLRCLHMGICPTEESKACTRYKLTSLNKSALDVLQDN
Length809
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.074
Instability index43.55
Isoelectric point6.93
Molecular weight90070.21
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22203
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.91|      49|     198|      77|     126|       1
---------------------------------------------------------------------------
   77-  126 (87.66/52.36)	LEWDQSGSRLLSADGD.GEI.KCWAM.KEHL.VNSWESIQSSSV.DGDPIVaLSW
  276-  329 (68.26/36.46)	LTRENSEQVLLCASSQmGSIvECWSLrKEGLpVNNIFQHRSPVVgEKQPMI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.52|      38|     372|     338|     407|       2
---------------------------------------------------------------------------
  368-  407 (62.70/80.31)	PGLGLaLSFHDG...SIQILHRLSLHtMGMFY...G...........SSGSSQRVGD
  719-  773 (55.82/19.88)	PSMDW.LPINDGvitKIQSKHQLRLQ.FGKPYtlpGlnpnsqmeifsRSPASQRMDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.14|      38|     372|     170|     208|       3
---------------------------------------------------------------------------
  170-  208 (53.93/38.90)	LAVTVSGLVTvSLLKP...NGAL........LSASESLCRLRGRVALADI
  504-  537 (21.24/ 8.68)	.............MRQ...NQALqqvlatriVAVKASLCKLSSATAARAN
  544-  584 (53.97/34.35)	LLIAISSTLK.SLLRPhvlNTPD........KSPGDRLAEICTKNTDTDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.39|      29|     190|     446|     474|       4
---------------------------------------------------------------------------
  446-  474 (52.57/34.48)	MIRVSPSMGQLLDMNTLLRHLLFLLEYCM
  637-  665 (54.82/36.28)	FLRDGPSLGMLREMMVMIRIWGLLKPGCL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22203 with Med16 domain of Kingdom Metazoa
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