<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22197

Description Mediator complex subunit 12
SequenceMAAFGMLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINIWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPATPAEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGLSTGGHPPHSISGQPGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATVPVFQDVLLQFLDTQAPVLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDTGSSVKMEDTGLSEPMEIEHNSSANFDEQMFSPPMHGEAKGSPSPEKAAPEQDGKSTAKEKCMDPAFPQVYEQPRHIQYATHFPIPQEESASHECNQRQVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGTEPQNEIVSNMNVCFTLSLFLSQGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLAGSYTTSLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYWNIDPSDSNMLWDQVFMIDAIANPSAHNLNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDDKSTVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNVSIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNASKLKPVLRWVTPIRIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTNEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTRFEEQQRLLLYHTHVKPRPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKSEKNVTSVPPDDYPARNPGVMPYGPGTNNELMNMGQSGHTYRMGYNQTSIIYTQNQPLPPGGPGLEPPYRPRMPVNKMPTRPNYPGNYHPGGMGIMGMDNKQYTMGFKPQTAMSQGQMLRQQIQNQSMLGQQMRPMNISQQGYTSYGSHMVMQPHPSQTGAIVPSQYGNQAFQGAHPGTNPGVVDPLRQMPRPSGYVHQQASSAYGMQNTQSNPVIVNHFPYRYRYQNYFVVTKQKQQQQVQQQQQQQQQVQQQVQQQQQQQQQVPSQQVQQPQQVPPQQVQQQQVPPQQVGAAQPPAQAQAQTLGMQPIVSAY
Length2004
PositionKinase
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.464
Instability index54.00
Isoelectric point6.25
Molecular weight224540.34
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22197
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.85|      18|      18|    1939|    1956|       1
---------------------------------------------------------------------------
 1922- 1940 (28.27/12.87)	VT..KQKQQQQVQQQQQQ.....qQQ
 1941- 1959 (31.39/15.24)	VQ..QQVQQQQQQQQQVP.....sQQ
 1960- 1985 (23.20/ 9.03)	VQqpQQVPPQQVQQQQVPpqqvgaAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.24|      24|      54|     636|     661|       2
---------------------------------------------------------------------------
  636-  659 (42.72/15.23)	PRPRSPSDEPSDESERKEQDTGSS
  663-  678 (17.81/ 6.85)	........EDTGLSEPMEIEHNSS
  689-  712 (39.71/13.47)	PMHGEAKGSPSPEKAAPEQDGKST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.76|      39|      54|    1194|    1233|       3
---------------------------------------------------------------------------
 1167- 1191 (21.25/ 7.55)	.CSEQD...SEPGARLTC.RillHLFRTPQ...............
 1194- 1233 (63.73/43.15)	PCPQDD..KSTVGIRSSCDR...HLLAASQNSIVVGAVFaVLKAV
 1249- 1288 (55.78/33.04)	PAGLDDigEDDMGSKKSGGR...N.VSIETASLDVYAKY.VLKSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     266.74|      52|      54|    1811|    1862|       4
---------------------------------------------------------------------------
 1716- 1748 (47.01/20.98)	.........G..TNN.E.....LMN.MGQSGHTYRM...GY.......NQT.SII....YTQ..NQPL
 1756- 1811 (70.12/35.07)	EPPYRPRMPV..NKM.PtrpnyPGN.YHPGGMGIMGmdnKQYTMGFKP.QT.AMS....QGQMLRQ..
 1812- 1862 (89.07/46.62)	.QIQNQSMLG..QQM.R.....PMN.ISQQGYTSYG...SHMVMQPHPSQTGAIV....PSQYGNQAF
 1866- 1919 (60.54/29.23)	HPGTNPGVVDplRQMpR.....PSGyVHQQASSAYG.......MQ..NTQSNPVIvnhfPYRYRYQNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.70|      36|     107|     984|    1019|       5
---------------------------------------------------------------------------
  940-  970 (35.95/20.94)	..........YHSCLIL.NpDQTAQVFDG.......LRIVVKS..........GVNPAD
  984- 1019 (62.80/42.69)	D........LYTSCSHL.K.SKFGEIFSE.......FCSKVKNS......IYWNIDPSD
 1025- 1072 (27.30/13.94)	DqvfmidaiANPSAHNLnH.SMVGKILNDspanrysFVCNVLMD......VC..VDH..
 1087- 1128 (49.65/32.03)	E........LTAYCRSL.S.AEWLGVLKA.......LCCSSNNGncgfndLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.72|      23|      24|    1478|    1500|       6
---------------------------------------------------------------------------
 1472- 1492 (28.09/14.84)	..TVQRSTQQTNEWAVLLLDIIS
 1493- 1513 (33.72/19.33)	SGTVDMQSN..NELFTTVLDMLS
 1548- 1565 (17.92/ 6.70)	KELGDRQSESLEKVRQLL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1586|    1600|       7
---------------------------------------------------------------------------
 1586- 1600 (20.41/15.86)	TKgNKIAGFEK.EGLQ
 1603- 1617 (22.26/11.75)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.69|      20|      24|    1662|    1683|       8
---------------------------------------------------------------------------
   13-   29 (24.34/ 8.28)	.PLKRP..RLGPPDVYPQD..P..
 1662- 1683 (34.52/21.08)	EPLPLPpeEEEPPTPVPQE..PEK
 1687- 1706 (23.83/ 7.94)	EAVKS....EKNVTSVPPDdyPAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.93|      20|      26|    1298|    1323|       9
---------------------------------------------------------------------------
 1298- 1322 (28.17/28.57)	CLKSLSEDSSALQDPvlvniQAQRL
 1327- 1346 (38.76/20.63)	CYPHRQLDSEEGDNP.....QRQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.33|      32|     107|     714|     745|      11
---------------------------------------------------------------------------
  714-  745 (61.95/38.30)	KEKCMDP.AFPQVYEQPRHIQYATHFPIPQEES
  821-  853 (53.38/31.92)	KRKRSKPeAFPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.94|      26|      54|     855|     880|      12
---------------------------------------------------------------------------
  855-  880 (43.79/25.66)	VSRNVLE......QITSFALGMSYHLPLVQHI
  882-  911 (24.84/11.49)	FIFDLMEyslnisGLIDFAIQLLNELSLVE..
  913-  933 (28.31/14.08)	...ELLL......KSSSLA.G.SYTTSLCLCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.65|      13|      34|     196|     208|      13
---------------------------------------------------------------------------
  196-  208 (25.11/15.84)	WEQLQKVAEFYRQ
  232-  244 (26.53/17.16)	WEYNEKLAMFMFQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22197 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESERKEQDTGSSVKMEDTGLSEPMEIEHNSSANFDEQMFSPPMHGEAKGSPSPEKAAPEQDGKSTAKEKCMDPAFPQVYEQPRHIQYATHFPIPQEESASHECNQRQVVLYG
2) DNKQYTMGFKPQTAMSQGQMLRQQIQNQSMLGQQMRPMNISQQGYTSYGSHMVMQPHPSQTGAIVPSQYGNQAFQGAHPGTNPGVVDPLRQMPRPSGYVHQQASSAY
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
4) MGYNQTSIIYTQNQPLPPGGPGLEPPYRPRMPVNKMPTRPNYPGNYHPGGM
5) PSQQVQQPQQVPPQQVQQQQVPPQQVGAAQPPAQAQAQTLG
6) SYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKSEKNVTSVPPDDYPARNPGVMPYGPGTNNELMNMGQSGHT
630
1789
15
1733
1956
1658
759
1895
64
1783
1996
1730










Molecular Recognition Features






MoRF SequenceStartStop




NANANA