<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22196
Description |
Mediator complex subunit 14 |
Sequence | MISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYLPAKCLTLAVWNQQVLGRKTGTASVHKVSIKIDETDGSKPLQISHEPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNSASHPVGSLSKHRLFIKLTRLPQYYIVVEMFDVANSSTELQYKYYFLSVSQLEGEDGLPCALLLQQFKPNLEELVQDLSSGRMLRPGTKRKLSGEQGATEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKGVSEETRKALDRTLLDCTFRLQGRNNRTWVAELVFTSCPLNSTSTKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLDFSRALPEMPSFLSLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCHSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLSMFVDSNQDARRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCVVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEQNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPEQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPARPGECTIFASVHELMANLTLNSGGRP |
Length | 1330 |
Position | Tail |
Organism | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes>
Characoidei> Characidae> Astyanax.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.184 |
Instability index | 52.17 |
Isoelectric point | 8.44 |
Molecular weight | 147771.90 |
Publications | PubMed=25329095
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22196
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 398.90| 117| 209| 644| 783| 1
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644- 783 (169.48/148.59) RKVVEmflnDWNSISQLYECVLDfsRALPEM.PSflslfSEIRLYN.YRKLV....LCYGNTKGSSVTIQWNSvTQRFHLALGTVG....PNSGcsncHNIilHqlqemFNKTPNVVQL...LQVLSDTQAPLNAINKLPTVPMLGLTQRTNT
860- 984 (191.97/111.27) RSVNE....DDNPPSPVGVDVMD..TLMPHMqPQ.....QPIRGQGvYPPLTsppnSYHGNVAPSPSMMPTQS.PGNIHAANSPSGalraPSP................FGPTPSPSSLgisMGQTSNFASPHGALDPSSPYPMVSPSQRTGT
992- 1025 (37.44/11.86) ....................................................................................SG....PSPG....ARI..H......GMSPGNPSL.............H......SPIPDASHSPRAGT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 216.06| 66| 209| 319| 400| 6
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179- 263 (104.44/61.65) CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYLPAKCLTLAVWNQQV...LGRKTGTASVHkvsikidetdgskplqisHEPPLP
330- 400 (111.61/83.07) CGRSECLHIFVD.LHSGMFqpMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLkfwLGEQRCRQSVK..................HLPTLC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.03| 14| 37| 1124| 1137| 10
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1124- 1137 (25.95/16.25) LKCRVALNPKSYQT
1162- 1175 (27.08/17.30) FETRVAGPPFKYNT
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