<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22195

Description Mediator complex subunit 6
SequenceMGGAIVRDTHSGDKNIASSSRVLGNMAAGDLRDNLLGISWVDSGWVPILNPGNVLDYFSERSNPFYDRTCNNEMVKMQRLTLDHLNQMVGVEYILLHAQEPILYIVRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGSVISSRVLSAVHGIQSAFDEAMSFCRYHPSKGYWWHFKDQEEREKVKPKSKKKEEPSSLFQRQRVDALLLDLRNKFPPMFYQPKPGEKPIPVEVKKEPELLAEPTKQEERETATKTPAPSGPSKPPPEKRARLQ
Length271
PositionHead
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.08
Grand average of hydropathy-0.608
Instability index52.35
Isoelectric point8.89
Molecular weight30783.83
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.09|      39|     124|      78|     116|       1
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   78-  116 (68.12/39.23)	QR...LTLDHLNQMVGVEYILLHAQEPILYIVRKQQR..QSPTQ
  200-  243 (60.97/34.45)	QRvdaLLLDLRNKFPPMFYQPKPGEKPIPVEVKKEPEllAEPTK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22195 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FYQPKPGEKPIPVEVKKEPELLAEPTKQEERETATKTPAPSGPSKPPPEKRARLQ
217
271










Molecular Recognition Features






MoRF SequenceStartStop




1) EVKKEPELLAEPTKQEERETATK
2) PSKPPPEKRARLQ
230
259
252
271