<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22192

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSACFVPNGASLEDCHSNLFYLADLTGIKWKGYVWQGPTSAPMLFPVTEEDPILSSFSRCLKADVLSVWRRSQRQGRRELWLFWWGEDPIFSELIHSELTGEDDGVWESGLSYECRTLLFKAIHNLLERCLMNRSFVRLGKWFVKPYEKDEKPINKSEHLSCSFSFFLHGDSNVCTSVEINQHQPVYHLSEEHLTLAQQASSPFQVILSPFGLNGTLTGQSFKLSDPPTQKLIEEWKQFYPISTSSKESTEDKMEDIDWEDDSLAAAEVLVGGVRMVYPACMVLVPQADIPTITPVGSSHCTAVYSGGHQVPASNRDPAISSVTLTPPTSPEEAQTVDSLTAQKWMRLPSAVDGFSVDSASHHGGKIPRRMASQVVERVWQECNMNRSLNKRKFSATGSGTSEEEVMEKMGSWDFVESVQRTTCNCSRHKTLKQRVGGAQGQPVSTGQVQQQPIKHKAGEKLDKGDKQQKRPQTPFHHRSSVSDDISMEADASASQRLALRGQECGRFTGLHPAEVCTVPKPPLLHTGGGAAGGAGVPSELVGSPQPPPLSPHPCDRVEEGSETLKNLSTPHSQHFYPTPSEPCLLPQKGPDDPCADSLAHPFHPAYSEATEPTVYIGTAVCLENDGNHMPWRFFNLPRRKDLDLPTPSLPTDKLKEEGLMGVNGNVSITEVMAISKHTLKVSGERVQTYLQRRNQHLAAAIADSDLEPEVDPYAFVDGDVKFTFSDKKDKAGIEREQGRKHKGDDGGAGTLDDAQRGAAHKTASSTSLIHDSDLTVSFKDLDNLFNSDEDEQTPGARRAVNGTDDKFGSKEPKTAMLDPVSCISSADLNQIFPTPPSLEPHIMGYSPMNMGGKEYGNMEPGPGMTSLDGSSALVSQFKIEVEESFCSPKPSEIKDFSFVYKPELCQAFVGCSMFAPLKTLPSQCLPPIRLLEECVYRPSWSVGKLELLNPIPAMNFLNRDSNIPSVGSAMEQDYNQSYTPQTHTPFISNSAPPSNSGTGILPSPATPRFSAPTPRTPRTPRTPRGPSSVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLFVTLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYINDPNMEAQYPCSCGFSAVVNRRYGNGSGLFLEDELDIIGRGSDVSREAEKRFEALRSTSLEKSPGGLQDRNPDELILLLQDQCTNPFPPLVAAEPEGTASGAPGSSVVPPCVRVEERDFHNDCYLALEHGRQFMDNMSGGKVDEVLVKSTCLHHWAKCNAVDVSALCSQDVLRVLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGFEYDFVVLSPFGLPYWEKLLLEPFGSQRDMGYLVLCPENEALINGAKSFFRELTAVYESCKLGQHRPISKVHADGIVRVGGAAAKKLSEQPISDWFLKGVCSTTEAFAKLKLFAQFCRHDLAPYLATQPLDSSLLTQPSPASYTTQTLPAQSSGSASSNPQSSLASGVSSLTSNTGTGNVGQGLQGSTSSMPSSGPQNGSVQPSKPSSFPPFGGMGVQSNSSQSGALGQQAGSQSSNLSGDNSSSSSQTQGSSEPPESTMEREKVGVPTDGESHAIVYPPAIMIYIVDTFSYEDAETGVAHSSVWTLGLLRCYLEMVQFLPPHIRNSISVQIIPCQYLLQPVKSEERQLYAQHLKSLAFSVFSQCRRPLPASTNVKSLTGFGPGLALDTALRSPERPECLRMYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLATCTDMYGELLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMTSVPWRVVIGRLGRIGHGELRDWSILLSRRNLQSLSRRLKDMCRMCGISSADTPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAFVQVNSSSYTPEDIAFNPINDGSDPIGGIFDLLEQESDLVDPDIISILPASPTTSPVHSPGSQYHHGGDGSKGQSTDRMESHDEAPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHIHVSSVQSDELLHGKHSHPLDSSQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2157
PositionMiddle
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.355
Instability index54.31
Isoelectric point5.55
Molecular weight235920.43
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22192
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     187.45|      36|      36|    1478|    1513|       1
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  527-  554 (37.66/12.68)	.TGGGAAG..GAGVP.SELVGSPQPPPL..SPHP.....
 1478- 1513 (59.66/24.54)	LTQPSPASYTTQTLP.AQSSGSASSNPQ..SSLASGVSS
 1514- 1551 (56.97/23.09)	LTSNTGTGNVGQGLQ.GSTSSMPSSGPQngSVQPSKPSS
 1562- 1590 (33.16/10.26)	.......SNSSQSGAlGQQAGSQSSN.L..SGDNSSSSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.36|      34|      36|      50|      83|       2
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   23-   45 (20.35/ 7.38)	..............ADLTGIkWKGYVWQGpTSAPMLF
   50-   83 (61.47/39.35)	EDPILSSFSRC.LKADVLSV.WRRSQRQG.RRELWLF
   87-  120 (53.54/33.19)	EDPIFSELIHSeLTGEDDGV.WESGLSYE.CRTL.LF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.88|      29|      36|     885|     918|       3
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  885-  918 (42.87/39.91)	SFCSPkPSEIKDfSFVYKPELCqafVG.CSMFAPL
  923-  952 (51.01/28.71)	SQCLP.PIRLLE.ECVYRPSWS...VGkLELLNPI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.00|      21|      37|     993|    1013|       4
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  993- 1013 (41.85/20.02)	PPSNSGT.....GILPSPA.TPRFSAP
 1027- 1053 (31.16/12.91)	PSSVQGSlkyenSDLYSPAsTPSTCRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.58|      84|     422|    1198|    1438|       5
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 1345- 1438 (132.25/291.59)	EYDfVVLSPFGLPYWEKLLLepfGSQRDM.GYLV.LCPENEALINGA...KSFFRE..LTAVYESCkLGQHRPISKVHADGIVRVGgaaakKLSEQPISDW
 1772- 1862 (136.33/40.43)	KYN.VLFVGYCLSHDQRWLL...ATCTDMyGELLeTCIINIDVPNRArrkKGSARRlgLQKLWEWC.LGLVQMTSVPWRVVIGRLG.....RIGHGELRDW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.06|      15|     124|     170|     185|       6
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  170-  185 (26.06/21.49)	GDSNvCTSVEINQHQ.P
  297-  312 (27.00/16.80)	GSSH.CTAVYSGGHQvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.19|      93|     418|    1615|    1713|       7
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 1615- 1713 (155.06/100.51)	ESHAIVYPPAIMIYIVDTfsyedAETGVAHSSVWT...LGLLRCYLEMVQFLPPHIRNSISVQIIPCQYlLQPVKSEE.....RQLYAQH..LKSLAFSVFSQCRRP.LP
 2037- 2140 (147.14/82.16)	EAPNILQQPLALGYFVST.....AKAGPLPDWFWSacpQAQNQCPLFLKASLHIHVSSVQSDELLHGKH.SHPLDSSQtsdvlRFVLEQYnaLSWLTCDPATQDRRScLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.10|      18|      34|     458|     477|       8
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  459-  476 (33.71/25.20)	GEKLDKGDKQQKRPQ..TPF
  968-  987 (30.39/10.70)	GSAMEQDYNQSYTPQthTPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.62|      39|     664|     479|     524|       9
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  479-  524 (64.52/55.58)	RSSvsdDISMEADasasQRL.ALRG....QECGRFTGLHPAEV.......CTVPKPPL
 1151- 1201 (58.11/34.35)	RGS...DVSREAE....KRFeALRStsleKSPGGLQDRNPDELilllqdqCTNPFPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.64|      19|      36|     355|     373|      10
---------------------------------------------------------------------------
  355-  373 (33.20/19.92)	FSVDSASHHGGKIPRRMAS
  394-  412 (31.44/18.43)	FSATGSGTSEEEVMEKMGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.30|      15|      37|     753|     767|      11
---------------------------------------------------------------------------
  753-  767 (24.64/12.49)	DDAQRGAAHKTASST
  790-  804 (25.66/13.30)	EDEQTPGARRAVNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.83|      22|      37|     147|     168|      13
---------------------------------------------------------------------------
  147-  168 (38.45/24.72)	YEKDEKPINKSEHLSCSFSFFL
  187-  208 (36.38/22.93)	YHLSEEHLTLAQQASSPFQVIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.81|      20|     664|     555|     576|      17
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  555-  576 (33.05/25.55)	CDRVEEgsETLKN...LSTPHSQHF
 1222- 1244 (32.76/18.46)	CVRVEE..RDFHNdcyLALEHGRQF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22192 with Med13 domain of Kingdom Metazoa
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