<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22190

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTEIFSTLFGQSEAQGPQGPGTLGFAPGKPPPLPQTQAPAPPQIPAQPGDEGPAARKPGVMNEPFYLLRELPAGNDLTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDCPGVQDGSSLRSLIEKPPVCGNSFSPLTGALLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHRHHRPQDPIPPAETPSDTDPKKKKKKRDDDPERKKKKKDKKKKKVGKVTKQKL
Length232
PositionHead
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.05
Grand average of hydropathy-0.994
Instability index52.82
Isoelectric point9.82
Molecular weight25628.32
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.47|      16|      26|      15|      30|       1
---------------------------------------------------------------------------
   15-   30 (33.47/17.23)	QGPQGPGTLGFAPGKP
   43-   58 (32.00/16.15)	QIPAQPGDEGPAARKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.06|      14|      19|     190|     203|       2
---------------------------------------------------------------------------
  190-  203 (25.72/11.79)	PAETPSDTDPKKKK
  210-  223 (23.33/10.01)	PERKKKKKDKKKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.13|      12|      19|      66|      79|       3
---------------------------------------------------------------------------
   66-   79 (16.54/13.32)	YLLRElpAGNDLTG
   87-   98 (24.59/12.66)	YNLEH..AYNKFCG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22190 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSTLFGQSEAQGPQGPGTLGFAPGKPPPLPQTQAPAPPQIPAQPGDEGPAARKPGVM
2) LPEQYRLMHIQPPKKKSKHKHRHHRPQDPIPPAETPSDTDPKKKKKKRDDDPERKKKKKDKKKKKVGKVTKQKL
5
159
61
232










Molecular Recognition Features






MoRF SequenceStartStop




1) PFYLLR
2) PKKKSKHKHRHHR
3) SDTDPKKKKKKRDDDPERKKKKKDKKKKKVGKVTKQKL
4) YRLMHIQ
64
171
195
163
69
183
232
169