<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22188

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDPAVRKLMEEWSHFYPMVLKRKENERDESNPTYDSHSHVALEVIVGGVRMIYPAAFVLVAHADLPVEQPPPAQGAQSGTRDSSNCGIPLTPPTSPEQPCSGDSGFQTAVSSVASHECGPAQSPKHTEKKLTNQMVHQAWKECYVNQLHHRCSLSNSMTPKKEVSNGLATWDFTDPGERAPCSCSRLRQQAKQQQASGSCANPQPGANPSSCPASSAPSLPPPSIPKHKPADKPDKSDKGPKRVAITPFHHRLSVDQQQCPDQDPPAGSQLALVPLDPPLDSLPSCKYPKPMSSIRKGPESLLHSPVSPLPPTLSPHPRVQDPEAMEAPVGLPHCLEGPPMPPPPEMSETALYTASLVPRDAGGGWWKSYRNPRVDKAEFKPSELPCDLLESKLESTGEGTVLKRLYAHTHKRFKISEERLREHISTLGFLQQPGVEGLTDPGDDPYDFKEGDIEYSFPTSKRLKGPGRDPNRKSKGEEMNSNNAVPEGKDAMSIFSSAPKSEELAQDESGAKANPPLTREKDLIVLISDLENIFGEEEDELGTTFPNHQQSTKTVAPGAEERPQGIDGRVAVPYPSTVAELQRMFPTPPSLEQHPAFSPNMTYRDTPSQEPPAPSAGVEHPLSAHANSQLNDFKMEVEDGMSSPKAEDARDFSYVYRVPSVQPQLGCSMFAPLRALPSQCLPPLKIPEQCYYRPSWALLPKMEHYCLPAQAPFLRDGYVNVPSISTLQDQDYSQMSTCTTSVGTVGGVLPSPATPRFSVPTPRTPRTPRGMGTASGQGSVKQDGTELSSPASTPSASLPLSSVEPAACGPALPEAHSLYAILLLSDSVLDVFKDRNFDSCCICACNTNVKGADVGVYIPDSTREDQYRCMCGFSAIANRRLAHGAGLFLEDELDIFGRGSEAGRAAERRLALCRRELPAGATRRGTQEPPMSVLGLIQEQCSQPITSLASLHKPAACSCRSRQGALLQSWAADRLWADSIDACVECYNALVQGLQYVDNATGGKVEQALVRSTALHSWPHTNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTLLVGYDRDFLALSPLALPFWEKLLLEPYGGQRDVAYLVLCPNNDPIINGARAFFQELSAVYESCRLGKHRPLGRVSRDGIVPVGVDEAEKLEEDLVDEWLTGPWSGQHHEDHLSKLKLYAQTCKQRLAQQLSVLSLDSSLLLLPKPQPSPAPTQPAQSTPSSQPTPEADAAAAAASAASAAASAASAAASAAPASGSTPTPTSTTSAAQAASAEQGQSETKNVPNSTLNPNNQPAESNENNSAERERIGIPTVADSADSHVHPPAIVLYMVDPFLCSGTGMGPGDDEEAEEVESGSVWLLSLLRCFSDMLSMLPENLQPAVVLQVVPCQYLLQPASGESPLYLQHLRSLAFSAHSQCRRRLPTQTQIKSLTGFGPAATVESLLKSPENPSSMQVYSPPFILGPTRSKQPEAGEVCSDTPARNNVLFVGYCLSHDQRWILVSCTDQQGELLETSIINIDVPNRSRRPKFSPRKIGLKKVWEWCISIIQMTAVPWRIVIGRLGRLGHGELKDWSLLLGEHSLHSISKQLREACRMCGISAADSPSILSACLVSMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQVAPSSYPTEDNPDDMFGLPFPDELENDIGHDMMFFTGNLHPSPNTSPVPSPGSPSGMGVGSHFQHTRSQGERLLSREAPEELKQQPLALGYYVSTAQAEGLPHWFWASCPQAQNQCPLFLKASLHHHISIAQTDELVSSKTSQRSPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRRSCLPVHLVILIQMYNAILNIL
Length1904
PositionMiddle
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.06
Grand average of hydropathy-0.418
Instability index59.93
Isoelectric point5.65
Molecular weight206810.02
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22188
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.20|      21|      24|     227|     250|       1
---------------------------------------------------------------------------
  229-  258 (23.36/13.78)	HKpadKPDKSDKGPKRVAITPF.hhrlsvDQ
  259-  286 (26.84/ 8.70)	QQ...CPDQDPPAGSQLALVPLdppldslPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.56|      23|      25|    1459|    1483|       2
---------------------------------------------------------------------------
  590-  613 (35.18/13.81)	PPS..LEQHPAF..SPNmtyRDTPS..QEP
 1459- 1483 (35.15/18.90)	PTQTQIKSLTGF..GPA...ATVESllKSP
 1486- 1506 (34.23/13.23)	PSSMQVYS.PPFilGPT...RS.....KQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.66|      22|      24|     307|     328|       3
---------------------------------------------------------------------------
  307-  328 (41.92/16.62)	PVSPLPPTLSPHPRVQDPEAME
  330-  350 (42.10/16.72)	PVG.LPHCLEGPPMPPPPEMSE
 1709- 1727 (32.81/11.12)	PTEDNPDDMFGLPF...PDELE
 1740- 1759 (31.83/10.53)	NLHPSPNT.SPVPSPGSPSGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.35|      29|      30|    1248|    1276|       4
---------------------------------------------------------------------------
 1248- 1276 (48.55/25.85)	APTQPAQSTPSSQPTPE.ADAAAAAASAAS
 1281- 1309 (43.71/22.36)	AASAAASAAPASGSTPT.PTSTTSAAQAAS
 1328- 1356 (39.09/19.03)	N.NQPAESNENNSAERErIGIPTVADSADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.44|      23|      29|      69|      97|       5
---------------------------------------------------------------------------
   69-   97 (38.28/30.20)	EQP.PPAQGAQsgTRDSS....NCGipltPPTSP
   98-  125 (36.16/14.95)	EQPcSGDSGFQ..TAVSSvashECG....PAQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.21|      20|      29|     162|     185|       6
---------------------------------------------------------------------------
  162-  185 (28.18/24.69)	KKEVSNGLATwdfTDPGErAPCSC
  194-  213 (39.03/18.71)	QQQASGSCAN...PQPGA.NPSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.11|      14|      15|     892|     905|       7
---------------------------------------------------------------------------
  892-  905 (24.30/14.76)	EDELDIFGRGSEAG
  909-  922 (24.81/15.24)	ERRLALCRRELPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.59|      24|     271|    1509|    1545|       8
---------------------------------------------------------------------------
 1522- 1545 (47.20/55.77)	LFVGYCLSHDQ.....RWILVSCTDQQGE
 1789- 1817 (42.39/20.65)	LALGYYVSTAQaeglpHWFWASCPQAQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.08|      27|      29|    1550|    1578|       9
---------------------------------------------------------------------------
 1550- 1578 (44.46/28.66)	SIINID.VPNRSRRPKFSprKIGLKKVWEW
 1581- 1608 (45.62/23.29)	SIIQMTaVPWRIVIGRLG..RLGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.55|      20|      24|     435|     456|      10
---------------------------------------------------------------------------
  435-  454 (38.65/23.96)	PGVEGLTDPGDDPYDFKEGD
  460-  479 (36.90/16.47)	PTSKRLKGPGRDPNRKSKGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.58|      20|     271|     674|     699|      11
---------------------------------------------------------------------------
  674-  698 (35.96/20.90)	PLRALPSqclppLKIPEQCYYRP.......SW
  946-  972 (31.62/ 7.81)	PITSLAS.....LHKPAACSCRSrqgallqSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.77|      23|      29|    1848|    1870|      12
---------------------------------------------------------------------------
 1848- 1870 (39.78/22.97)	PHPLDSKTTSDV.LRFVLEQYNAL
 1877- 1900 (35.99/20.05)	PATQDRRSCLPVhLVILIQMYNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.17|      40|     271|    1370|    1427|      14
---------------------------------------------------------------------------
 1387- 1427 (67.60/31.97)	EEVESGSVWLLSL.LRCFSDMLSmLPENLQPAVVL........QVVPCQY
 1660- 1708 (57.57/21.55)	DAVTMGSVFGRSTaLNLQTSQLN.TPQDASCTHILvfptssttQVAPSSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.73|      21|      56|     500|     520|      16
---------------------------------------------------------------------------
  500-  520 (37.56/20.75)	APKSEELAQDESGAKANP.PLT
  558-  579 (35.17/18.90)	APGAEERPQGIDGRVAVPyPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.32|      12|      16|    1204|    1215|      22
---------------------------------------------------------------------------
 1204- 1215 (21.48/16.01)	QHHEDHLSKLKL
 1222- 1233 (18.84/12.94)	QRLAQQLSVLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      20|      24|    1089|    1111|      23
---------------------------------------------------------------------------
 1092- 1111 (38.41/26.65)	PLPI.PTLLV...GYDRD..FLALSP
 1113- 1138 (23.87/ 6.41)	ALPFwEKLLLepyGGQRDvaYLVLCP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22188 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLPVEQPPPAQGAQSGTRDSSNCGIPLTPPTSPEQPCSGDSGF
2) DMMFFTGNLHPSPNTSPVPSPGSPSGMGVGSHFQHTRSQGERLLSREAPE
3) FPTSKRLKGPGRDPNRKSKGEEMNSNNAVPEGKDAMSIFSSAPKSEELAQDESGAKANPPLTREKD
4) GEEEDELGTTFPNHQQSTKTVAPGAEERPQGIDGRVAVP
5) PATPRFSVPTPRTPRTPRGMGTASGQGSVKQDGTELSSPASTPSA
6) PSTVAELQRMFPTPPSLEQHPAFSPNMTYRDTPSQEPPAPSAGVEHPLSAHANSQLNDFKMEVEDGMSSP
7) QQQASGSCANPQPGANPSSCPASSAPSLPPPSIPKHKPADKPDKSDKGPKRVAITPFHHRLSVDQQQCPDQDPPAGSQLALVPLDPPLDSLPSCKYPKPMSSIRKGPESLLHSPVSPLPPTLSPHPRVQDPEAMEAPVGLPHCLEGPPMPPPPEMSETALYTA
8) SLLLLPKPQPSPAPTQPAQSTPSSQPTPEADAAAAAASAASAAASAASAAASAAPASGSTPTPTSTTSAAQAASAEQGQSETKNVPNSTLNPNNQPAESNENNSAERERIGIPTVADS
65
1733
459
537
754
577
194
1236
107
1782
524
575
798
646
356
1353










Molecular Recognition Features






MoRF SequenceStartStop




1) ASAASAAA
2) GWWKSYR
3) PYDFKEGDIEYS
1272
366
447
1279
372
458