<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22186

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAVPLAGCSPAAEPANTAAVPGPAERLRVEEGTEAEKQTRVSALLERLHAKHNAARPWQETSKIVRQAMEKRGVMNSAGHQLLLSCLETLQKALKVSSLASMTDRLESIARQNMLGSHLSPSETECYITSDMFYVEVQLDSSGQLVDVKVAHHGENPASCPELIQHLREKNFDEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSIEMDLTKMMHMFRLATSANTVETILHGSVGLLTLRSGGNLLSLQCYVSPYDIFEEGSGTQLSFTDSNIPHSLGVSVYVTVEGTSAVYKLPIAPLIMGSHPVDNKGTPTFSPVTNSNCVDLPACFFLKMNCPMPFSLSFIQKMGNVTGISVFESAPTLSSLYDLIIKSQLGEEEGASPPASGRSMRFYAALPGQQHCYFLNGDAPVQDGRSLQGALVSKIPFRHPAHVPPLLEIIRHQAAYNTLIGSCVKKTYIKEDTPGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVACKLYKGLSDALICTDEFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEIMVKKNLPPTGSPGYMGMGPGPDGNNPLGLPSVGGATPTGGSGAGGIGAVGAFQGPITSMYNMGRQVSVESIGPVGNQQQQMQQQPSQHSHGSDDFSKVTQNPILTSLLQITGSVGSSPTPQASAGSQPHQTPPPTTSPASNTKNHPMLMNLLKDNPSQDFAALYGSSPLERQNSSGSPRTDSQGQPCSAGGPKGKKKRPRATDKGMMGAGGMGMKQSQQQQMGGMSQQHHHTHHPTEDDFHRELFSMDVDASQNPIFDVNLPGDGLDTPHSITPAPSQCGTPPSGPGMSYHSQSHVQAQTQAQSQPGSLQRMVRLSSSDSIGPDINDILSDIPDQATKGSSGSHGQHHMGGEEGGSLGTPLRDSSSSGQGSTVFDSDLFNANSNENPFADPADLIAEATTAATPNSDASSSNFFPDTDFNPELLSGQGTFSQSYFEDSSPSPDPDLDLVKGFSGGSQQNTPSGTPQNPTSHGRNTPDASLKDPFDIGLVFGGSSGGGKPLLGPAPDMGDPHPTHGVGGQSPLMMSMGVGSDFKSSEVKVKQQQMRPKEDNGGGNSGMGMGGSGSSEGKQMKRSRTPSSEGKSKEKPPKRKKLDPDGKSPSHSSGGRPYTPPSGSASSGGSISGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPRIGGKTSSHGGYTSSSSTGGSSGGASGTSSSKSHHSHSSSSGKIKSSKMEGSMGQGNSSKPTSTGGGGSGMSSQSKSSSLGMGSGKPGSSPVTKHGMSGSGSGGSSGGVSGNKIKPQGGKPPGSMMNPNIKPNISPSHSRSGNSDKLSSPLKHQQGQVPGTPPSSKAKSPIGSGGGSLGGSKSSSSGGMSSQKQLGSGSSSGSSSSSNSSASSSSSSGSMSFSSSGQAQYGGGSGSGGGGGGGGGGGGGGGGNNPNAKGKSPSRNKKPSLIAVIDKLKSVGSGGIGGEEGEGGGCGGNGNSSGSGGGVPQNIGHASSKQGISSQGGEYLNKRDKSEKESKSKVSVSGGSSSDKKLMDQKSGGVSSTGVAKIIISKSDGGSPSIKSKVTLQKPGEGAGEGSMRSQHSGLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNQDSESESGSSSVAEKSHQNSPSSDDDQAMRPIQPPQDYMSSMSVSLGEKHKKHKKEKKKQKDRERDRDRDRDRDRERDREKEKKKSAMSCAPSSHPMKADSWSRSPMSSSETSMSMLGSERPPRPSSPMYMHTEDDDLMDSALTGNL
Length1801
PositionMiddle
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.04
Grand average of hydropathy-0.662
Instability index58.28
Isoelectric point8.78
Molecular weight186484.85
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22186
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1292.03|     174|     176|    1113|    1286|       1
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  575-  703 (114.96/19.34)	....................................................GYMG..MG.........PGPD.....GNNPLGlpsvggatptGGSGA..........G.GIG.AVGAFQ..G..PitsmyNMGRQVSVESIG................PVGNQQQQM.....QQQPSqH..SHGSDDF...SKVTQNPilTSLLQITG...svGSSP..TP........QASAG..SQ..P..HQTPP.PTTS...P....ASN
  704-  902 (180.54/35.15)	TKNHPMLMNLLKDNPSQDF..AA...LYGS..SPLERQNSSGSPRTDSQGQPCSAGgpKGKKK.....RPRATdkgmmGAG............................GMGMK.QSQQQQmgGmsQ.....QHHHTHHPTEDDFHRElfsmdvdasqNPIFDVNLPGD.....GLDTP.H..SITPAPSqcgTPPSGPG..MSYHSQSHvqaqtQAQS..QP........GSLQRmvRL.SSSDSIGPDINDILSDIPDqaTKGS
  903- 1035 (168.43/32.23)	SGSHGQH....HMGGEEGG..SL...GTP.......LRDSSSS............G..QG...........ST.....VFDSDL..........FNANS..........NENPF.ADPADL..I..A.....EATTAATPNSDASSSN..........FFP.....DTD......FNPE.L..LSGQGTF..............SQSYFE.....DSSP..SPdpdldlvkGFSGG..SQqNTPSG.TP.......QNPT..SHGR
 1040- 1221 (268.28/56.31)	ASLKDPFDIGLVFGGSSGG..GKpllGPAPdmGDPHPTHGVG.GQ...SPLMMSMG..VGSDF.....KSSEV.....KVKQQQ...mrpkednGGGNS..........GMGMG.GSGSSE..G..K.....QMKRSRTPSSEGKSKE..........KPPKRKKLDPD.....GKSPS.H..SSGGRPY...TPPSGSA..SSGGSISG.....GGSK..SP........GSSGR..SQ.TPPGGATPPIPKITIQIPR..IGGK
 1222- 1390 (249.30/51.73)	TSSHGGYTSSSSTGGSSGG..AS...GTSS..SKSHHSHSSSSGKIKSSKMEGSMG..QGNSS.....KPTST.....GGGGSG.......mssQSKSS........slGMGSG.KPGSSP..V..T.......KHGMSGSGSGGSSG...........GVSGNKIKPQ.....GGKPP....GSMMNPN...IKPNISP..SH..SRSG.....NSDKlsSP........LKHQQ..GQ.V.PG..TPPSSK..AKSP...IGSG
 1391- 1526 (165.05/31.42)	GGSLGGSKSSSSGGMSSQKqlGS...GSSS..GSSSSSNSSAS....SSSSSGSMS..FSSSG.....QAQYG.....GGSGSG......ggggGGGGG..........GGGGG.GN.........N............PNAKGKS..............PSRNK.KPSliaviDKLKS.V..GSGG........IGGEE..GEGGGCGG.....NG.N..SS........GSG..........GG....VPQ.............
 1527- 1689 (145.46/26.69)	...NIGH.ASSKQGISSQG.......GEYL..NKRDKSE.......KESKSKVSVS..GGSSSdkklmDQKSG.....GVSSTGvakiiisksdGGSPSikskvtlqkpGEGAGeGSMRSQ..H..S.....GLKAS..PLFSGST..............PKH.....D.....RSSPS.HsrSPGYTPL...NQDSESE..SGSSSVAE.....KSHQ.nSP........SSDDD..QA.MRP..IQPP................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.01|      64|     121|      83|     153|       2
---------------------------------------------------------------------------
   83-  153 (97.70/72.58)	LLLSCLE.TLQKALKVSSLASMTDRLESIARQN..ML.....GSHLSpseTECYITS.DMFyvevQLDSSGQL..VDVKVAH
  201-  275 (87.31/50.02)	LALQSIEmDLTKMMHMFRLATSANTVETILHGSvgLLtlrsgGNLLS...LQCYVSPyDIF....EEGSGTQLsfTDSNIPH
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.31|      15|      15|    1709|    1723|       3
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 1709- 1723 (23.36/19.13)	KEKKKQKDRERDRDR
 1725- 1739 (24.95/21.03)	RDRDRERDREKEKKK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22186 with Med1 domain of Kingdom Metazoa
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