Description | Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDLAPDNDWRSPGFRQKVVAQIEEAMRKAGTAHAKTSNEMENHVFIKAKSREEYLSLVARLIIHFRDIRKLSVSGCQADRSFQRYP |
Length | 86 |
Position | Tail |
Organism | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.638 |
Instability index | 35.98 |
Isoelectric point | 9.57 |
Molecular weight | 9948.25 |
Publications | PubMed=25329095 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP22184 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) MDLAPDNDWRSPGFRQKVVAQIEEAMRKAGTAHAK 2) NHVFIKAKSREEYLSLVARLIIHFRDIRKLSVSGCQADRSFQRYP | 1 42 | 35 86 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab