<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22177

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVESKEFGKDSVFPQKVVLCSVSARNIIAFSSLQSAIVSHGPGDSSSGAGVAVGASNSHVYVSDIVTPWEYYKVCSSKSLINVLEWSANGEQLLLGYVGGRVEIWQPKHQSINIWLLQYHANIPSEDIIEAKFFHNGKGVLFNPQKKEHTYYAEKFERLEQRPTLSGFGGVASEGCILLTSSGLLGAFSLPLLQKFPSTEGACSEIVELTPVMHSIGISRSFIEHCSMAPSPSGAVNVAFSCGWQQQLVQCFKISLVMEGDLGLEQHMAIKSESQASIFLNPLEGKLISHLKWTRVANDDVIFIAYSCPEGGSLLEQWTLTRRHQSVHTLLQGGGSNKGNEFVQSESWEQVAKLHLNAPLADLCLSRLVPTAADCSPVYAILQDNSVQVLEPNSLKQLNHTQFDKVSVSDGSGVKFVSGDLTPTSQMLLIFDTHAQLYAMQAPPLKQSGSALLLLEYCIVTGCDASDVLLLNLGSLEPLVEKLTDNFSRQPSFVKNYYYANFLALKSNLCRVQQQEFDNLIILHAISTTFKSLLRPSDLGYQDKGPADNLTTKLNESIPDVDTVMLNLDAKDFTVEPVMLQSLQPLIQWVTDLAVNMLNRLPEEVMKCKLSGKRPSYDISRDINAISSLRELLVMIRIWGLLNTQCLPVYTKIMENIDVLVILFRLLTRLAQNPAEPDDMLLDECSLLSKQLLIPQLNKFNPTTLLSAQGFAAVKSGHLMFTSLVEPTCLQDMEVEDVVFARSVKDGVSNLQLGAHPTTIRRCARCGFVFVNNANKVAKTSALKAWFNKWLHCHCGGFWKQIN
Length808
PositionTail
OrganismDrosophila guanche (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.08
Grand average of hydropathy0.025
Instability index46.60
Isoelectric point6.01
Molecular weight89340.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22177
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.85|      73|     148|     580|     658|       1
---------------------------------------------------------------------------
  580-  658 (115.98/113.21)	VEPVMLQSLQ....PLIQWVTDLAVNM.LNRLPEEVMKCKLSGkrpsYDISRDINAISSLRELLVMIRIWglLNTQCLPVYTKI
  730-  807 (120.88/98.14)	VEPTCLQDMEvedvVFARSVKDGVSNLqLGAHPTTIRRCARCG....FVFVNNANKVAKTSALKAWFNKW..LHCHCGGFWKQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.26|      28|     148|     122|     151|       2
---------------------------------------------------------------------------
  122-  151 (47.24/41.49)	LQYHANIPSEDiiEAKFFHNG.KGVLFNPQK
  269-  297 (44.02/31.46)	LEQHMAIKSES..QASIFLNPlEGKLISHLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22177 with Med16 domain of Kingdom Metazoa
Unable to open file!