<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22174

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNANVGGARWEPEVNNFNYGSQSQFVNAGETGNASNSKKNESSHINGTFEPADKLNPNSDTSMVDAMMLAMPPELAHITQGFFPFTKLVNRSVQQCWNDLSDLVTELAEVQVPSFQGSATPSIPINGKSPGCQSPENVHKKLRILEFAHGKRADFIKLLVLSQWSRQAADVSKLIDIQGFVRSRHQAYAGALQWLGDMKRDLVRAQIANPDLKTALEVLSKGKMVAMPNLGYKPPKPLTTKSTLKKLQKLNRIIGVRLALHDQFPYPFQTYRIHDGRVTFHVAGEFELDLSVGQENQSSQFFFVNIRLLFFPSSPVPKGWVLNELDMKVNDVLREKGLFGCFGFLHNLVLTNKIQALYKQAANLARGPWSDVLRAELLHRTLVVQYWASKPGPKSWIEIGIRSGCRADGRTSSREQGIPHLGLRWMLDGQEVNSGDVLFDTAHLSMECILRSVIALHICRILLSAYSKLSKSLLFSSAELFLQIQLSMTEPGNCGLNVQLTPSRGLRVSVEPMSGACILSTTANALERPESERNSDKASDDEIVSRVSRLRCMAAIEEIESNMKMLGFETINPRGLRLDVRKIFPPNVLRFSLFWHNIWGRNWILAATSSMDSDNWWLVQFREAFPSRPDSRTGFTVDAGASLSPIVRSQIISSTFQPARQPLNYASFADLGHCLTGILAVYANACYLADIQSIAFYPSLQRLQIESSFQVPDMFIRYEPANLPSALRLALPAGLKGNSFMKETIRLTFYGIDAQTGAAIMVAYGNLRIPVKALDALIPKCDDRSLTFQRTGGGFALRLLSPPGHSVIIDLIITLQRLECVLSIAESIQQKKMAVESFSLSQVVFAYSPERGLSAAVHIEYFGALQNESVDPAGLALRNEPLFHARLSISFDHGSPHRRIQESLMAILNNESGDAGFDSAVEVLSLTHPLLRALDRITANPSLRGQLRTQVTVRNATSFQIRYPTYRSRFHLTTGQYLDRVTWILKDASGVQDDANRTEIAARLQNGLYNSKGDGWRGLGNGVAAEVDKMENLLSALDKCFEGVPGAPAATAVGDQEENGKSPGKMQAGTTKDNQPSTDSDLRGLNVPTTEGSRREPGISNGVGTISIE
Length1115
PositionTail
OrganismAspergillus sclerotialis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Polypaecilum.
Aromaticity0.08
Grand average of hydropathy-0.186
Instability index49.73
Isoelectric point8.56
Molecular weight123076.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22174
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      26|      39|       7|      34|       1
---------------------------------------------------------------------------
    7-   34 (38.97/32.83)	DNANVGGArWEPeVNNFNYGSQSQFVNA
   47-   72 (45.64/28.41)	ESSHINGT.FEP.ADKLNPNSDTSMVDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.68|      19|      39|     656|     674|       2
---------------------------------------------------------------------------
  656-  674 (35.05/27.39)	QIISSTFQPARQPLNY.ASF
  696-  715 (29.63/21.79)	DIQSIAFYPSLQRLQIeSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.06|      34|     378|     584|     620|       3
---------------------------------------------------------------------------
  585-  620 (61.27/50.13)	DVRkiFPPNVLRFSLFWHNIWGR.NWILAATSSMDSD
  966- 1000 (58.79/36.93)	QIR..YPTYRSRFHLTTGQYLDRvTWILKDASGVQDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.76|      21|      34|     430|     450|       4
---------------------------------------------------------------------------
  430-  450 (38.23/29.66)	RWMLDGQEVNSGDVLFDTAHL
  466-  486 (32.54/23.97)	RILLSAYSKLSKSLLFSSAEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.49|      41|      41|     840|     880|       6
---------------------------------------------------------------------------
  840-  880 (67.01/41.25)	AVESFSLSQVVFAYSPERGLSAAVHIEYFGALQNESVDPAG
  882-  922 (69.48/43.04)	ALRNEPLFHARLSISFDHGSPHRRIQESLMAILNNESGDAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.38|      24|     271|     547|     571|       7
---------------------------------------------------------------------------
  547-  571 (36.55/26.23)	DEIVSrVSRLRCMAAIEEIESNMKM
  816-  839 (39.83/23.97)	DLIIT.LQRLECVLSIAESIQQKKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.21|      21|     271|     103|     139|       8
---------------------------------------------------------------------------
  112-  133 (33.98/51.01)	ELAEVQVPSFQGS.ATPSIPiNG
 1087- 1108 (34.24/ 8.62)	DLRGLNVPTTEGSrREPGIS.NG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.72|      35|     227|     158|     192|       9
---------------------------------------------------------------------------
  158-  192 (60.05/40.63)	RADFI.KLLVLSQWSRQAADVSKL.IDIQ......GFVRSRHQ
  380-  422 (47.67/30.67)	RAELLhRTLVVQYWASKPGPKSWIeIGIRsgcradGRTSSREQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22174 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FVNAGETGNASNSKKNESSHINGTFEPADKLNPNSDTSMVDA
2) PGAPAATAVGDQEENGKSPGKMQAGTTKDNQPSTDSDLRGLNVPTTEGSRREPGISNGVGTIS
31
1051
72
1113










Molecular Recognition Features






MoRF SequenceStartStop




NANANA