<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22171
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTEADPKRIHILLRELQNLVKNAQEQWGITLTGQGSINDKLKAFAPVANAVHPLGPVNIVGLSTEFSQKIALIRSTLSNFRNTTVHDISQLNLSIGSDSLLKRYQFALLEESNNLNTVSEVRENIKICKELALDICQNSQDTFKFVIQQTSIFCKQLGLKVWEVEQSHGSTLTLSISGYIIVMDIKFDETAHKIVQVTITYTHKPEDDDRIDNLLTLQLSNFRYFKLFKKNLQALATLDMLSKIYSVNCFHCIRCISNDVKSIYEKEFSALAGDIQKMLTDGHGIPLFHVERVGPSIAYWAPKFRIHETDWNNVKNIIAKGDSCESLGSFYQLWIMMEESRSRNTFLPIERNHYLIEENDDEYELLQSYDFMPQDLTFPLLPTPLKVLQQPKDGSQTSANIQFVLWLFPPVYVTDTVAKEIEDLAGFFGSRIMTDDPKSLSLEQLLISDIVPPAKMTRGSAMDVSWEKKFEDSPYIQMYTLDMKHTNAKKIERFPFIYPFQIFSFIEILRQQLVYNALFQSCFNASTYCPQRISSQSSAANFEVNSNTTKVKVKVQATNPPHLLSVSFQLPDIMVDVLLQITILRDCQPYVISQNPLWEDKGNTDTVLTQTLQLCHDVPYLVKWILKSSINNFKSIKEDELMEL |
Length | 644 |
Position | Middle |
Organism | Gigaspora rosea |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina>
Glomeromycetes> Diversisporales> Gigasporaceae> Gigaspora.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.175 |
Instability index | 45.50 |
Isoelectric point | 5.62 |
Molecular weight | 73755.81 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22171
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 94.22| 28| 35| 227| 254| 1
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227- 254 (49.71/33.79) LFKKNLQALA..TLDMLSKIYSVNCFHCIR
263- 292 (44.51/29.53) IYEKEFSALAgdIQKMLTDGHGIPLFHVER
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 224.89| 75| 389| 137| 219| 7
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137- 219 (107.94/104.90) QNSQDTFKfVIQQTSifckQLGLKVWEVEQSHgsTLTLSISGYIIVMDIKFDETAHKIVQVTItYTHKP..EDDDRIDNLL..TLQL
536- 614 (116.95/83.82) QSSAANFE.VNSNTT....KVKVKVQATNPPH..LLSVSFQLPDIMVDVLLQITILRDCQPYV.ISQNPlwEDKGNTDTVLtqTLQL
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