<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22152

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMNVEFQKTLSNLEDKLNALITSLTISPTASGAPAAAIALLDADDSLTSAIETLRRHQENYARILKLRAEAESLEEKVKGIVRDVVSYEKEIRTICGDDEASDSDADDVSDDDDLDYGEDQMQTKPGGLRKTKEIDYKLLLDFARRISKYNHQAAADAAANATQAAKARGRGSQPGDQDMAVTGVNGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQVYMIPYPMEDRIRMGLMGQIQLTAAEDRPGFDPDREVERLIREAEGLGATEPVVPAPLPMGEERRHANEAAKAAAQAGAASSGITAAPAPAPKPKATLDLDLYDPDDDEMM
Length328
PositionMiddle
OrganismAspergillus thermomutatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.04
Grand average of hydropathy-0.567
Instability index39.46
Isoelectric point4.51
Molecular weight35288.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.99|      30|      62|      12|      44|       1
---------------------------------------------------------------------------
   12-   44 (39.82/31.62)	LEDKLNALITSLtIS.....PTASGAPAAAIAllDADD
   73-  107 (45.16/25.50)	LEEKVKGIVRDV.VSyekeiRTICGDDEASDS..DADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.33|      45|      74|     173|     217|       4
---------------------------------------------------------------------------
  173-  217 (79.34/48.78)	QPG.DQDMAVTGV...NGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQ
  245-  293 (68.99/41.45)	RPGfDPDREVERLireAEGLGATEPVVPAPLPMGEERRHANEAAKAAAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22152 with Med4 domain of Kingdom Fungi
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