Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNVEFQKTLSNLEDKLNALITSLTISPTASGAPAAAIALLDADDSLTSAIETLRRHQENYARILKLRAEAESLEEKVKGIVRDVVSYEKEIRTICGDDEASDSDADDVSDDDDLDYGEDQMQTKPGGLRKTKEIDYKLLLDFARRISKYNHQAAADAAANATQAAKARGRGSQPGDQDMAVTGVNGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQVYMIPYPMEDRIRMGLMGQIQLTAAEDRPGFDPDREVERLIREAEGLGATEPVVPAPLPMGEERRHANEAAKAAAQAGAASSGITAAPAPAPKPKATLDLDLYDPDDDEMM |
Length | 328 |
Position | Middle |
Organism | Aspergillus thermomutatus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.567 |
Instability index | 39.46 |
Isoelectric point | 4.51 |
Molecular weight | 35288.82 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP22152 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 84.99| 30| 62| 12| 44| 1 --------------------------------------------------------------------------- 12- 44 (39.82/31.62) LEDKLNALITSLtIS.....PTASGAPAAAIAllDADD 73- 107 (45.16/25.50) LEEKVKGIVRDV.VSyekeiRTICGDDEASDS..DADD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 148.33| 45| 74| 173| 217| 4 --------------------------------------------------------------------------- 173- 217 (79.34/48.78) QPG.DQDMAVTGV...NGGPGAEEGAEPVSSVTKEATSWLDESAKMTRQ 245- 293 (68.99/41.45) RPGfDPDREVERLireAEGLGATEPVVPAPLPMGEERRHANEAAKAAAQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EAAKAAAQAGAASSGITAAPAPA 2) KPKATLDLDLYDPDDDEMM | 286 310 | 308 328 |
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