<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22150

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEPNIATLSGDSPTNGFTILKHLSRLKDLELRLRNLDCLVSSYPRRLGLWVFSATPDFESLGPLCSNGTSDDPSKLFVGSATLKVSASGSVTSKELVKNLSAEPVSAATNSQGVQRRQNGPNPARRTDGHGSSAAIYASFISAVTGALSLQLIRCNNAIPLGSRTLFTVVAEDYYDNPRIDNDDPAAVPSLTTLQIQLTSVGKLTVSLQTISQPGIVRLCGPYDTSVGVQNAHPGCDLWLSPSGSVARLVATQSGFQDASSPSIIPCVGGHTMANPPSMLNLKQWKALVIEWLGNYGLSLLSSEEEPWVEVEVWEPFYSRLAGETWRQNEEGVSVLPLKRILWPARYCFKRKKPTSFDPFLGIDDTFPVIDEPLGFAEKWFGMGQLEHEETDSKPASRHEPETKDEETPLSRSDLPVGIESLSRAAEYPDLQASSLVYPTPPDGAFPVGPNAPAASDTAAEDLDSRHLTNPTSAKVKTKEKASAKERSDHDVLMSFGPSPGLIVGSGLYDTNDDDDLFGEINQRDFGSKGITDADFSFFDDPEFSHLSGDVNDMDAGAQETPEVAIEADEPKTQPLPLEQPLTDNLPRQRDITEQVVTTLAHPEEKVSNLQPAYVPLSDSMHISSPTNEDNQTISPPLSPIEVKKTLFPGPSEDGQLSVKKGHLQGHYNPVAFKQNILDWDQKYGAEGIFRVTGAVVNNHTVPTSTTGDIPTIGLPRRNARTKNPDHGAARNIDKSRSPASDLDQPIPSDSDFDSTSDTSDDSDGNLSNSDASVATFLTRKRKRARSHSRSSAGLPQEKPSARSEPSIATSRTDDLVFLGNFLSTFSDWSMTGYFSATQKQLSPVLIRNDVQIQVAQLLADQVTQSCLDHKVDGILGVSDFESKAYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGLSPPSTSAMSRQSSQRKDNGKSSMLKLAPPHLRVRRGKDYLEVLPPAVSFWETFGLEPAYGSKDISAYCIHPQVAAEAANDFLERLGLLYSSCNLGQHTRASRSTGFDRGMYSWNIGAPGELNYHSIMQSLKSICDKLVTALLKSPPTKDTVVVYIINPFSHAAALADICFAFWGLFQKYIDEVEKQQAGQANELVLQIVPFHFVMSTESLVVLPQAQYLSLALEVYSRCPPKGLQPCLLNCAPPMLVAEPVPKTINFKLAPDRSSPLQEAKSLHIACSRSYDQRWVSVSWTDNTGTLQRTMSYCLRFQNSNAARNILEVRNEIWGATKIIMEKTQARWKIIIVNTEPVDQDEVDTWTSLVEQYNMTKPFLSDLTILYVNTTPDLYLEPPPQPLPMSVFNPQISSTPVATPNPSGNVFSPEQSGTAPTPPSGGNAPTPTEIPLDAESECLLTDICDESWGVILSHCLNTSPHLTDYRPALASGYLLRRKGPTEADGAFAMNVNLIYAQKPASSYENILREIIARYRDLATLARARGTRTVQQNTFPWHIATAVRAQELLSYIL
Length1506
PositionKinase
OrganismAspergillus thermomutatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.354
Instability index53.36
Isoelectric point5.09
Molecular weight165072.34
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22150
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.83|      21|      31|     441|     466|       1
---------------------------------------------------------------------------
  441-  466 (27.55/30.05)	LPVGI......ESlsrAAEypDLQASSLVYPT
  472-  498 (34.28/19.25)	FPVGPnapaasDT...AAE..DLDSRHLTNPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.36|      72|     284|      66|     154|       3
---------------------------------------------------------------------------
   66-  145 (103.35/81.55)	VSSYPRRLGLWvfSATPDFESLGPLCSNGTSDDPsklFVGSATlKVSASGSVTSKElVKNLSaEPVSAATNSQGVQRRQN
  359-  388 (38.96/12.21)	VSVLPLKRILW..PARYCFKRKKP.....TSFDP...FLG........................................
  906-  962 (86.05/47.23)	.................DFESKAYSLRTFLEDTA...FMGEIE.RLDLNGFVSLQE.NSGLS.PPSTSAMSRQSSQRKDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.18|      10|     284|    1109|    1118|       4
---------------------------------------------------------------------------
 1109- 1118 (22.25/14.17)	LADICFAFWG
 1394- 1403 (21.92/13.84)	LTDICDESWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.09|      34|      73|     572|     605|      10
---------------------------------------------------------------------------
  572-  605 (57.44/35.70)	HL..SGDVNDMDAGAQETPEVAIEADEPKTQ.PLPLE
  611-  643 (37.55/20.44)	NLprQRDITEQVVTTLAHPEEKVSNLQPAY...VPL.
  648-  679 (48.10/28.53)	HI..SSPTNE.DNQTISPPLSPIEV..KKTLfPGPSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22150 with Med13 domain of Kingdom Fungi
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