<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22149

Description RNA polymerase II mediator complex subunit
SequenceMIPHSSAGVQSWGHPLHAVHSGAGRADLSQHLGQSDLQSEQPSMPVPQPQTRQPVLIDLTANGGDVPERDPPAKRLKLDVHAGSVAGDGSPASAGVGESKSTPSTTTSKPPPLSWRARPVWSFQALLSEVSGSAENNGESAAAVMQDVKPPSPPSFPAPPWKFAPADTTTSDPTGGQDGAPAKEVQTAPYQIETPSVAPVMGGEKVADFSPWTGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQVHSMVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGRLLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTNGALAIGLEAKWVRDWTANVQQFLEGVITSCGVADWKLKMTYAVSLTARLFFEQLLDHDQYLGWFLTSLEAAPLNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQLAIKSDSAKSLRPLTDRLSLHIRKLTLEHTSSVVLPDSWEKYKDLLSSCLNLKDNVHRAVFQNLAERNARVQRPRKCQETTQQPPQQRLIQLFDSIRSSHDIASVSAASLGAIDDKAALVFKLLEWAATPFRYGVSRVYTAARLLRKWKIAGVDVDTCIISFLAESQMRDQSNMDNIYHIISELVRSQTFSVGKYLQWLMAKGVADCCQNAEHKRLSGDLVLLMQLPASRLPEHVRNLRNTLLHRAGVEVSKEASTIAMLKASIAERLPKIFGPVARSAISCDLLPSDLTWAVKSEIGQWIRRGVTECGRGPPSKFQGLHRAPEAEHFALTPGEFYSIRDILESFGDLSILADVLKQATICNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVESYARLKRLGSTSLDLIFSLIDLGLRLPGEFNTVALLRQDLCRIESKSSMAAPSPLSDHIPATFNEADPRFLEKLDQLLLSGSGIDESTLDTIFNLLINQIESSGGHAKLSVNETCRYLAYLRPFHPKRFDLMLVRWICGLLKSTTRAILSQILPPLIGVGCVTIQAFVFLVRRLLKSEKVSSLISNPSDLRIDLLQLLVPPPAGQSRYFDMVTYRFHLSQKEFLFKHPEEAFNIIRDAIALIDSQSQEGTYRQRRVDLGHSAMVLLQILLTKNPESAVQHCTEKLIGQHPSSVTALTRALDSLLGFDTKAGERSFTSNTCFLSSYPLTPGSAPPDISVAEKVIELTNDFSLPFCQLKLQLLFNAETGGDVRNEIVDVMFKAAVVDSRSRRSNWVGLVRLMSHDAVRQIRERAEKSFFAIPLFEESPDGCSSFAADNSSSLETAKLYLTIIEKLAYSIPDAGPQAVAPVLTEKMDLLLQRLINMQTNYSGTTELSHGVDAEQMIRSRAQFERSLAFWFSALLRMIVLHRTAFSVPSAALRPTALPEQTRLLISIFCITLARLPDNVLRLFPTADYFPHSMRAGGCHPCPGILLQTHALDVAASLIDTFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNLTLPVSLPSPAASGSTPAPTPSGNLTGGPSHSQQPALVSSGVPTGLPDGLNCGASHLCLQYRGRVIGAYPVRPWELLEDAAPIVGANDTAVSLGYFDARRVRV
Length1619
PositionKinase
OrganismAspergillus thermomutatus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.136
Instability index47.82
Isoelectric point8.80
Molecular weight178310.34
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22149
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.49|      26|      96|    1257|    1283|       1
---------------------------------------------------------------------------
 1257- 1283 (43.12/37.57)	RSNWVGLVRLmSH..DAVRQIRERA..EKSF
 1351- 1380 (37.37/26.15)	QTNYSGTTEL.SHgvDAEQMIRSRAqfERSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.82|      37|      96|     460|     499|       2
---------------------------------------------------------------------------
  460-  499 (46.70/45.96)	RRLAELlLDKLQLA..IKSDSAKSLRPLTDRLSLhIRKLtLE
  558-  596 (55.13/37.28)	QRLIQL.FDSIRSShdIASVSAASLGAIDDKAAL.VFKL.LE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     255.60|      84|      90|      71|     158|       3
---------------------------------------------------------------------------
   71-  100 (12.12/ 7.58)	...........................................................................PPAKRLKLDVHAGSVAG..DGSPASagvgESK
  101-  186 (147.81/84.45)	STPS..TTTSKPPP...LSWRA....RPVW.....S...FQALLSEVSGSAENNGESAAAVMQDVKPPSPPSFPAPPWKFAPADTTTSDPTGgqDGAPAK....EVQ
  187-  250 (65.37/31.77)	TAPYqiETPSVAPV...MGGEKvadfSP.W.....TgnhPEDVLNE..QTAKQGYYDRTQVSQNESNTARPSLYA................................
  279-  321 (30.30/ 9.79)	TAPS..TF..KPPPrvtLTDNK....REAWlrdlaN...PSVPLRRLSRTIPHG.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.61|      31|      96|     607|     637|       4
---------------------------------------------------------------------------
  607-  637 (53.73/39.45)	SRVYTAARLLRK..WKIAGVDV..DTCIISFLAES
  700-  734 (42.88/29.85)	SRLPEHVRNLRNtlLHRAGVEVskEASTIAMLKAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.02|      29|     151|     738|     768|      10
---------------------------------------------------------------------------
  738-  768 (43.23/32.16)	RLPKIFGPVA..RSAIsCDlLPSDLTWAVKSEI
  892-  922 (46.79/26.14)	RLPGEFNTVAllRQDL.CR.IESKSSMAAPSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.08|      14|     149|    1314|    1339|      12
---------------------------------------------------------------------------
   43-   56 (28.20/ 7.33)	SMPVPQPQTRQPVL
 1323- 1336 (25.88/10.27)	SIPDAGPQAVAPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.86|      36|     172|     853|     889|      13
---------------------------------------------------------------------------
  853-  889 (55.26/43.22)	CV.IGATTDLFKRLVESyARLKRLGSTSLDLIFSLIDL
 1028- 1064 (55.60/37.71)	CVtIQAFVFLVRRLLKS.EKVSSLISNPSDLRIDLLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.88|      21|      23|    1526|    1547|      17
---------------------------------------------------------------------------
 1526- 1547 (37.99/21.46)	PA.ASGSTPAPTPSGnLTGGPSH
 1551- 1572 (35.89/15.83)	PAlVSSGVPTGLPDG.LNCGASH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22149 with Med12 domain of Kingdom Fungi
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