<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22133

Description Glucose-6-phosphate 1-dehydrogenase
SequenceMDPCMELKQNTTIVVLGASGDLAKKKTYPALFGLYRNQFLPKDVKIVGYARTKMDHDEYIRRIKSYIKTPTKEIEQQLEDFAGLCTYVSGQYDKDESFQGLEQHLQEVEQGHSENHRLFYMALPPSVFTIVSQHLKKICYPKNGIARVIVEKPFGKDLASSRELQKSLEPDWNEQELFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIVRDVMQNHLLQVLTLLAMERPISFNAEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPAYREDDTVPQDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLVLDCLKGDQSNFVRDDELDASWRIFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTSSYGYKFSDAAGYQWPTTNAAAAPNKFMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTIPNSDVEDASSENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSQLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEEIQWMSDVNTQLSLRLNLEDFDKIPHPFRNYEIDSGRVTFKVSGEFEVDLTIADEDFEKQFWFIDFRFAFKPATSSIPEGLKNYLESHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQANQMSRGSWTGTLKVEPLNRALAIQYWTSRTQPGSPKSWVLVAVASGKKANGQPDSKLPSHLTAKWYRDNKEVKDENITFDTDNLSAEALMKTVIGRHIDFLLGSVHSRLLSFPRFQNRQAAMVLRSSQDDPAASSLTMQVGYKDSATLLIEPTTGVFAVKPHSKFTWSPENQLNNGKNPAEDGAACLENVRCAVMEDELSRRGSTTGWSIKRSPLNKDELRSLTNTREWTKTIWLHRAGWEANWFVMVLLSPSGDVWWLVDVNRNASGQAPRLASRLPLNKGYPRLDDEFWNNLTLFASGMIAQAVDQRELHKQNIKFKPHGANNWSLPQQVRLPTLEIALSGIFPSMVFDSAEKDNPKTAGTTESGKSGSVTRSASGSGISAKQPWANDIVSVRFKGVQPAEAESTGPESVKLGDGKPEVPFTCVSDAIIKVRRPAKFAMLKSHMVGRDVSWNARTGEFCLRMRSSIGQSMLESLKARVKAVDRFVSFFESMDRAKESIVAESVSLKEVTFSYGPLASEATNKDQPSRLWRITLNLSQNDIDLAMEETNPHLPVTNLMQKLVNGANGIGALMNWLPESLPALEAVKKIRETWRDVEARHQGRFRFMMDSVDEMSIQYSLVGTGPGNQPVHRDITFLAHIKHRRGEPWWHIMRKPLNGPAPNDEFSKALKPVWEATGEKWTGLVTGAAGRPHDGIASLLLAIDEAVRPLAGSSFQNNSEVVVLE
Length1519
PositionTail
OrganismFusarium sporotrichioides
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.09
Grand average of hydropathy-0.406
Instability index39.22
Isoelectric point6.76
Molecular weight171240.05
Publications
PubMed=29649280

Function

Annotated function Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
glucose-6-phosphate dehydrogenase activity	GO:0004345	IEA:UniProtKB-EC
NADP binding	GO:0050661	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
glucose metabolic process	GO:0006006	IEA:UniProtKB-KW
pentose-phosphate shunt	GO:0006098	IEA:UniProtKB-UniPathway
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22133
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     870.60|     310|     418|     326|     743|       1
---------------------------------------------------------------------------
  350-  720 (441.84/403.51)	QFKDVTSGIFKDIpRNELvmriqpnESVYIKMNSKLPGLSMQTVVTELDLTYrrRFSDLKIPEAYESLVLDCL.KGDQSNFVRDDELD....ASWriftpllhYlDDNKEIIPMEYPYGS...RGPAVLD.......DFTssYGYKFSDAAGY.QWPTTNAAAAPNKFMSDPAGEIVHITQGYiplSKVLTRLAQSTHNALqdQIAALAKMPL.PAAAMNgNSTIPNSD............VED........ASSENIAKKTSILN....FAMREHRKWVKALviteWsrkadmvsqlidlrFHLQGQE......VLFTGALDV..MGHVKRDltfARMPSPDLKTALQvLSTG.....EAAWmPDLSyiepppLTREEEIQwmSDVNTQLSLRLNLEdFDkiPHPFRNYEIDSG.RV.TFKV..SGEF
  743-  822 (78.01/56.25)	AFKPATSSIPEGL.KNYL.......ESHVNDILSKDGLLGCYQFLHELVLTH..KLNELK........................................................................................................................................................................................rqanqmsrGSWTG.TLKVEPLN....RALA.IQYWT.....................................................................................................................................................
  826- 1140 (350.75/188.51)	............................................................QPGSPKSWVLVAVaSGKKANGQPDSKLPshltAKW........Y.RDNKEVKDENITFDTdnlSAEALMKtvigrhiDFL..LGSVHSRLLSFpRFQNRQAAMVLRSSQDDPAASSLTMQVGY...KDSATLLIEPTTGVF..AVKPHSKFTWsPENQLN.NGKNPAEDgaaclenvrcavMED...elsrrGSTTGWSIKRSPLNkdelRSLTNTREWTKTI....W..............LHRAGWEanwfvmVLLSPSGDVwwLVDVNRN...ASGQAPRLASRLP.LNKGyprldDEFW.NNLT......LFASGMIA..QAVDQRELHKQNIK.FK..PHGANNWSLPQQvRLpTLEIalSGIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.75|      33|     142|    1231|    1285|       2
---------------------------------------------------------------------------
   29-   67 (49.87/19.17)	PALFGLYRNQFLPKDVKivGYARTkmdhDEYIRRIKSYI
 1231- 1263 (61.87/64.57)	PAKFAMLKSHMVGRDVS..WNART....GEFCLRMRSSI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22133 with Med14 domain of Kingdom Fungi
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