<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22130

Description Choline-sulfatase
SequenceMAPDLNSLPTSHGETSTAPTPQLVSETDRPNILFIMADQLAAPQLKMYNPDSQIKTPNLDRLASTSVQFDSAYCPSPLCAPSRMSLISGQLPMKIGAYDNAAQIGSDVPTYAHYLRSKGYHTSLAGKMHFIGDQLHGYEQRLTSDIYPGDFGWAVNWDEPDTRLEWYHNASSILQAGPCGRSNQLDYDEEVMFKSTQYLWDHVREGPNKRPFALTVSLTHPHDPYTITKKYWNLYEDVDINLPEVKMNKEDLDAHSKRLLKVCDLWDQDFTEEQIKRAKRAYYGSVSYVDDCIGRLLETLEDAGLAENTIVIFSGDHGDMLGERGLWYKMSYFESSVRVPMLINYPKRFTPHRVTQNVSTLDLLPTICDLVGTKPSPYLPMDGISMLPHLEGREGHDTVIAEYTGEGTIRPMMMIRRGDWKYITCPADEPQLYNLARDPKELDNLARFRKIAPQTAEEEEAKEAFHKFEAEAHVRWDFDAITEKVLLSQRTRRVVWDALKEGEFTSWDHNPDDDGRKKYIRSYMDLDDLERRARFPVVDAHGYESKAVSHMAPLWKIGCVIFRARSGRSLVFHRNVAPAWDHDVENLGSSITKRPNNRHCAPYLRVNVMATLNLEDDELKALEQTLSKVAQLSSSVQSFRQDLLKSNPLPPPKSIQASAKILQKNLRSLLESTNENADLFNRMAIHPSTNYPGRIHENVLLQLLRKKLEPDIEELVSQGLETSRLATPAGLESLERIWKELRAWLSDRVGYFASNENNDPYTAEERANGTENVRTGLRRDIEEDDDDEEDEEEEEEEQSAAAPVQVRGPEPETLLWFAARGDFEVPRNVEYERKEDTFKGVYVYKGLQGVGIPPTVQPPPQLQQDSVPS
Length869
PositionHead
OrganismFusarium sporotrichioides
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.09
Grand average of hydropathy-0.637
Instability index52.12
Isoelectric point5.14
Molecular weight99019.97
Publications
PubMed=29649280

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
sulfuric ester hydrolase activity	GO:0008484	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      23|      69|     183|     217|       1
---------------------------------------------------------------------------
  183-  206 (37.33/19.55)	NQLDYDEEVMFKSTQyLWDH..VREG
  250-  274 (34.61/21.24)	EDLDAHSKRLLKVCD.LWDQdfTEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.51|      55|      69|     286|     343|       3
---------------------------------------------------------------------------
  131-  167 (38.57/16.39)	.........IGDQ................LHGYEQR.LTSD...IYPGD...FGwavnwDEPDTRLEWY..............
  286-  342 (92.62/56.34)	VSYVD..DCIGRL................LETLEDAGLAENTIVIFSGD...HG.....DMLGERGLWYkmSYFESSVRVPML
  358-  432 (78.32/38.67)	VSTLDllPTICDLvgtkpspylpmdgismLPHLEGREGHDTVIAEYTGEgtiRP.....MMMIRRGDW...KYITCPADEPQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22130 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NENNDPYTAEERANGTENVRTGLRRDIEEDDDDEEDEEEEEEEQSAAAPVQVRG
755
808










Molecular Recognition Features






MoRF SequenceStartStop




1) FKGVYVYKGLQGVGIPP
2) LLWFAAR
838
814
854
820