<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22129

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFHPQTPQSPSQFSSGTSEPVLSVATSMTTTTTPTTLPTPAHSVTGSAHHDLTMADDSPQKRKRSVDDSGDREQKKFHVEESKLGIEDLHLDVGKKYLLCQTPHPETLPRVSEDLYDMFNLNALAAEVAREKPNGEKNALRSSYTGHMKRLGVAGHWKVQRTDKDSNEKPDFFDILHMPDEDWDNTIVKGQNIKHGLSQASLSALGRAVAMTKGPLGKKDWDTSVLGLQSPGGESKLPSSARPTAPNTPLNVPGAVGRLKAQGTSTNDPNRPKRNVKKRTYGDSSFEGYGEGYPDDDTAMEGGYSTGEGEGSQKRRKTNPGNASPYPSAMRQQSYGPGMVGA
Length343
PositionHead
OrganismFusarium longipes
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.910
Instability index45.48
Isoelectric point7.20
Molecular weight37146.72
Publications
PubMed=29649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.28|      34|      80|     122|     159|       1
---------------------------------------------------------------------------
  122-  159 (48.08/52.66)	LNALAAEVAREK.PNGEKNaLRSSYTGhMKRLGvaGHWK
  203-  237 (56.20/41.61)	LSALGRAVAMTKgPLGKKD.WDTSVLG.LQSPG..GESK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.89|      38|     209|      30|      72|       2
---------------------------------------------------------------------------
   30-   72 (57.64/41.26)	TTTTTPTTLPtpahSVTGSAHHDLTMADDsPQKRKRSVDDS..GD
  245-  284 (63.25/32.44)	TAPNTPLNVP....GAVGRLKAQGTSTND.PNRPKRNVKKRtyGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22129 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGKKDWDTSVLGLQSPGGESKLPSSARPTAPNTPLNVPGAVGRLKAQGTSTNDPNRPKRNVKKRTYGDSSFEGYGEGYPDDDTAMEGGYSTGEGEGSQKRRKTNPGNASPYPSAMRQQSYGPGMVGA
2) MSFHPQTPQSPSQFSSGTSEPVLSVATSMTTTTTPTTLPTPAHSVTGSAHHDLTMADDSPQKRKRSVDDSGDREQKKFHVEESK
217
1
343
84










Molecular Recognition Features






MoRF SequenceStartStop




1) FFDILHM
2) PYPSAMR
3) QKRRKTNP
173
326
314
179
332
321