Description | Mediator of RNA polymerase II transcription subunit 19 (Fragment) |
Sequence | ALSPYRSDISAAGLARHATPVPREETSFMMSFHPQTPQSPSQFSPATSSDPSLGSSGSAAAAGTGTTTLPTPAHSVNGSSSQPDSIMLDDSPQKRKRPLEDVGDDRELKKAHIDDYKLAIEDLHRDVGLKYLLLQSPHPESLPRTSEDLYEMFDLVNLAAEVAREKPNGEKNALRKTYKGHIKRLGVTGHFDVQKKKEDSPSDFLSMLQVPDHEWNVHQVKGRALMDGLSEVTKSTLGRALTMAKGPVAKSLWDTSVLGDIGPSNGDSSKAPSAKPTAPNTPLISMPGAAMNRPKSQLLPGQNPARPQRSIKKRSYGDSSYEGYGEGFPDDDTGLETGYSTGEGEGGQKRRKKASENRNPNYDAAGIF |
Length | 368 |
Position | Head |
Organism | Trichoderma arundinaceum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.793 |
Instability index | 53.85 |
Isoelectric point | 6.89 |
Molecular weight | 39692.69 |
Publications | PubMed=29649280 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP22125 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.91| 15| 18| 222| 238| 1 --------------------------------------------------------------------------- 222- 236 (25.90/10.47) GRALMDGLSEVTK.....ST 238- 257 (20.01/12.54) GRALTMAKGPVAKslwdtSV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.07| 14| 18| 96| 109| 2 --------------------------------------------------------------------------- 96- 109 (24.51/17.79) KRPLEDVGDDRELK 117- 130 (23.57/16.83) KLAIEDLHRDVGLK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.08| 13| 21| 185| 197| 4 --------------------------------------------------------------------------- 185- 197 (22.86/13.88) LGVTGH.FDVQKKK 208- 221 (21.22/12.45) LQVPDHeWNVHQVK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAGIF 2) GGQKRRKKASENRNPN 3) GYGEGFP | 364 346 323 | 368 361 329 |
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