<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22124

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESGGQNGALSDHHKDSAVNGIHGVKGIDGSKVAPDKGKATATPTTNDGNNAVNGGAAGGPRTDSPIEQASRMNNLPDEIIHITQGFVPLSLLLTRLAQSTHNMVQDKIAELAKMPVPAVATNGSTNYTQSAPDDTSPENLRKKAMMLHFIQDMHAKWVKALVIVEWSRKASMVSKLIDLKFHVDQQRILFDTALDSIINVKRDLTYARMPAPDLKTALQILSTGTAPWMPDLQYIELPPLTIEEQLKGIGDLDTLLSLRLNLDDFDKLPYQFRNYSIGSGRVTFKVDGEFEVDLTIADEDFEKQFWFIDFRFAFRPASLSLSESLRAYLENCVNEALAKDGLTGCYQFLHEFVLTAKINELKRQALQLSRTSWTGTLTVEPLNRALAIQYWTSRSAATGQKNWVIVAVNSGRKQGSRPDAKASSFLVVKWYRDNKEVKDVEIEANVENLSAESLLRDVVGRHIEFILSNIYAGLLAAPRFKNRETGVGYGGTVSLLIEPTSGAFAMKPHSKFSIQPELQLNNGKNPTEDGVNFLEHLRCAIIEDELGRMGTARGWSVRKAPINVDELRSITKMRKWSRTLWLQHGGWGPTWFVVVMLSLDGDEWWLLETDPATANGISKFYTRLPLNKGAPQVSGAFWDNLNLFAAGMITQSVDMRELHRRKIKSQSNGSIDLSLPQQVRMPSVEVALSAIFPTMMQDYAEDVVSQNTSGAEASEDLQILALLRSKSGVSASAKQPWAENMVAIRFKGVHSVPRREETSEGRVTIHDLVCTSDAVIRVRKPAKFLALKGMVDRDVSYNPQRGEFVLQIQRRVTEPIFDVLKSRIKAIDRFVNFLEAMEKAKGSIISESITLKGVVFCYSAPLSAPLNGEAAAPERWRVKMDLSNEEIDIHIDKGNPHLRVIDLARNLASTEGGIGSLMAWLPVSLPALKAIDQLDAQWDELSKQGQGRLNFSMKSLTWMNLKYTTFGPQGTGEKTRSNICLDVRIRPRRGEGWWHAWRSDTDAADDEYNRALKAVWDGKGNNWLGLSSGAAAQANDGVMNMLLAIDKAIRGVLLASMSRPPNGGKTEPITLD
Length1073
PositionTail
OrganismTrichoderma arundinaceum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.07
Grand average of hydropathy-0.289
Instability index39.66
Isoelectric point7.31
Molecular weight118989.34
Publications
PubMed=29649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22124
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     917.44|     284|     297|     345|     641|       1
---------------------------------------------------------------------------
  207-  452 (257.51/164.24)	......................................................YARMPAPD..LKTALQiLSTGTAPWMPD.LQYIE.LPPL...TIEEQLKGIGDLDTlLSL.R...LNLDDFDKLPyQFRNYSigsgRVTFKV......DGE.....FEVDLTIADEDfekQFWFIDfrfaFRPASLSLSESLRAYLEncvneaLA....KDG.........ltgcyqFLHEF...VLTAKIN..ELKRQALQlSRTSWTGTLTVEPLNRALAIQYWTSRSAATGQKNWV..IVAVNSGRKQGSRpDAKASSFLvvkwyRDNKEVKDVEIEANVENLSA
  453-  744 (459.62/262.77)	ESLLRDVVGRHIEFILSNIYAGLLAAPRFKNRETGVGYGGTV..SLLIEPTSGAFAMKPHSKFSIQPELQ.LNNGKNPTEDG.VNFLEHLRCA...IIEDELGRMGTARG.WSV.RKAPINVDELRSIT.KMRKWS....RTLWLQ......HGGWGPTWFVVVMLSLDGD...EWWLLE....TDPATANGISKFYTRLP......LN....KGAPQVSgAFWD......NLNLFaagMITQSVDmrELHRRKIK.SQSNGSIDLSLPQQVRMPSVEVALSAIFPTMMQDYAedVVSQNTSGAEASE.DLQILALL.....RSKSGVSASAKQPWAENMVA
  751-  940 (200.31/107.26)	HSVPRREETSEGRVTIHDLVCTSDAVIRVRKPAKFLALKGMVdrDVSYNPQRGEFVLQIQRRVT.EPIFD.VLKSRIKAIDRfVNFLEAMEKAkgsIISESITLKGVVFC.YSApLSAPLNGE....AA.APERWR....VKMDLSneeidiHIDKGNPHLRVIDLARN........LAS....TEG....GIGSLMAWLP......VSlpalKAIDQLD.AQWD.....................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.00|      14|      25|     142|     155|       2
---------------------------------------------------------------------------
  142-  155 (26.50/19.76)	RKKAMMLHFIQ.DMH
  169-  183 (19.50/12.59)	RKASMVSKLIDlKFH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22124 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESGGQNGALSDHHKDSAVNGIHGVKGIDGSKVAPDKGKATATPTTNDGNNAVNGGAAGGPRTDSPIEQASRMNN
1
75










Molecular Recognition Features






MoRF SequenceStartStop




NANANA