<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22121

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPVPAAAMNGNSTTPNSDVEDASGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEQIQWMSDVNTQLSLRLNLEDFDKIPYHFRNYEINSGRVTFRVPGEFEVDLTIADEDFEKQFWFIDFRFAFHPAVSSIPEGLKNYLEGHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQASQMSKGSWTGTLKVEPLNRALAVQYWTSRTQPGGPKSWVLVAVSTGKKANGQTDPKSSSHLTAKWYRDNKEVKDGVIAFDSDNLSAEALIKTVIGRHIDFLLGSIHTKLLSFPRFKNREASLVLHSSQEDPADSSLTMEVGFKDRVTLLIEPTTGVFAVKPHSKFTFDKENQLNSGNNPAEDGAACLENVRCAVVEDELSRRGSTAGWSIKKNPLNNDQLKALTNTREWTRTIWLHRAGWEPNWFVMVLLSPGGDVWWLVDTTRSASGHVPRLSSKLPLNRGFPRLDDEFWNNLTLFASAMIAQMVDQRELHKQNIKFKPHGSNNWSLPQQVRLPTLEIALSGIFPSMVFENAEKNNPRTAGGSSSTAESVKSGSVVQSATGSGISTKQPWANDIISVRFKGVQPAEEASTGYESIKSEGDKSEKPFICVSDAIIKVRRPAKFNMLKSHMVGRDVSWNAGSGEFRLRMRSSIGQSMLENLKARVKAVDRFVSFFESMDQARESIAAESVSLKEVTFSYGPLASETSTDTQPSRLWRITLDLSQNDIDLIMEEPNPHLPVTDLMQKLVNGANGIGALMNWLPESLPALEAIKKIRETWKDIEARNQGQFRFVMDSVDEMSIQYFVTGTGPGNQPLHRDITFLAHVKHRRGEPWWHIMRKPLNSSFAPHDEFTSALKPVWEARGEKWTGLVTGAAGRPQDGIANLLFAIDEAIRPLAGSSFQNNSEYVVLD
Length1023
PositionTail
OrganismFusarium sp. FIESC_12
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium incarnatum-equiseti species complex.
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index33.94
Isoelectric point6.63
Molecular weight114429.52
Publications
PubMed=29649280

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22121
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.78|      18|      34|     929|     946|       1
---------------------------------------------------------------------------
  929-  946 (36.26/25.71)	HRDIT.FLAHVKHRRGEPW
  961-  979 (31.53/21.31)	HDEFTsALKPVWEARGEKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.11|      17|      34|     107|     126|       2
---------------------------------------------------------------------------
  107-  126 (26.93/22.30)	DLRF..........HLQgqeVLFTGALDVM
  132-  158 (24.19/11.96)	DLTFarmpspdlktALQ...VLSTGEAAWM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.26|      31|      34|     472|     502|       3
---------------------------------------------------------------------------
  472-  502 (55.34/36.05)	NP.AEDGAACLENVRCAVVEDELSRRGSTAGW
  507-  538 (56.92/37.31)	NPlNNDQLKALTNTREWTRTIWLHRAGWEPNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.37|       9|      33|     192|     201|       4
---------------------------------------------------------------------------
  192-  201 (13.68/11.77)	EDFDKiPYHF
  228-  236 (18.69/11.06)	EDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.90|      23|      29|     838|     862|       5
---------------------------------------------------------------------------
  838-  860 (40.61/31.13)	NDIDLIMEEPNPHLPVTDLMQKL
  865-  887 (39.29/22.58)	NGIGALMNWLPESLPALEAIKKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.48|      23|      33|     729|     751|       7
---------------------------------------------------------------------------
  729-  751 (41.72/30.55)	IKVRRPAKFNMLKS.....HMVGRDVSW
  760-  787 (32.76/22.30)	LRMRSSIGQSMLENlkarvKAVDRFVSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.23|      15|     596|     315|     329|      12
---------------------------------------------------------------------------
  315-  329 (28.67/15.61)	LAVQYWTSRTQPG..GP
  333-  349 (19.56/ 8.57)	VLVAVSTGKKANGqtDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.35|      27|      49|     641|     667|      14
---------------------------------------------------------------------------
  641-  667 (44.07/23.27)	SMVFENAEKNNPRTAGGSSSTAESVKS
  691-  717 (44.28/23.42)	SVRFKGVQPAEEASTGYESIKSEGDKS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22121 with Med14 domain of Kingdom Fungi
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