<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22119

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRASSASFRVGPPSPSSPAAESLKETLLPTISDQIPQTPTSPPLMSVSAHNYATHFVPSQTSPSQATSQHTSLSSPPSSAPMSTQPSQQPVVGVSANSFPTPASSVSGHVPGTTSLDEPDAQTKPMGSGSSNTSAFPVGTESATTHRRTDHDRQPGGDSESAVRDHAAMGDAMDIDKEAPGSSHEGSMSLESLQQDFSSAFHLCKSSYTATGPDPSLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKHEPGAPGGLLQMTMWPEEEWQNQKVFGKEMKVADMDSALHALQMKAMKMEPGAVPNSEQWEDVLGHEKPSKHAGGGSDASKKTVAPLNGARTQASGTPGPGGSETRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKDHVSKISTPLPDRGGSYGVGMFGIGAR
Length446
PositionHead
OrganismAspergillus homomorphus (strain CBS 101889)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.05
Grand average of hydropathy-0.742
Instability index51.22
Isoelectric point6.32
Molecular weight46887.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.89|      18|      21|     184|     203|       1
---------------------------------------------------------------------------
  184-  203 (26.14/21.64)	SSHEGSMSLESLqqDFSSAF
  208-  225 (31.75/19.23)	SSYTATGPDPSL..DLISLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.24|      50|      92|     228|     277|       2
---------------------------------------------------------------------------
  228-  277 (88.71/43.62)	GPVAKSVARMDPVTGEKINRLR..KSYEGKLKGLGLAGRNKPVKHEPGA.PGG
  296-  324 (40.82/16.55)	GKEMK.VADMDSALH.....................ALQMKAMKMEPGAvP..
  326-  371 (64.72/30.06)	.....SEQWEDVLGHEKPSKHAggGSDASKKTVAPLNGARTQASGTPG..PGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     117.12|      16|      19|      37|      52|       3
---------------------------------------------------------------------------
   14-   28 (19.82/ 6.62)	.PPS..PSSPAAESLKET
   37-   52 (31.20/14.81)	IPQT..PTSPPLMSVSAH
   59-   72 (23.35/ 9.16)	VP.S..QTSPS.QATSQH
   82-   99 (21.21/ 7.62)	APMStqPSQQPVVGVSAN
  101-  111 (21.54/ 7.86)	FP.T..PAS....SVSGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.49|      22|      24|     136|     158|       4
---------------------------------------------------------------------------
  113-  131 (18.98/ 6.68)	...P.GT...TSLDEPDAQTK.PmgsG
  136-  158 (37.22/23.90)	SAFPvGTESATTHRRTDHDRQ.P...G
  163-  183 (30.29/14.74)	SAV...RDHAAMGDAMDIDKEaP...G
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22119 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDGAFYSNSEGMGKKKRKKDHVSKISTPLPDRGGSYGVGMF
2) LHALQMKAMKMEPGAVPNSEQWEDVLGHEKPSKHAGGGSDASKKTVAPLNGARTQASGTPGPGGSETRPSRGRKRHYDDNSFVGYG
3) MSDRASSASFRVGPPSPSSPAAESLKETLLPTISDQIPQTPTSPPLMSVSAHNYATHFVPSQTSPSQATSQHTSLSSPPSSAPMSTQPSQQPVVGVSANSFPTPASSVSGHVPGTTSLDEPDAQTKPMGSGSSNTSAFPVGTESATTHRRTDHDRQPGGDSESAVRDHAAMGDAMDIDKEAPGSSHEGSMSLESL
400
308
1
441
393
195










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHVSKISTPL
2) TLLPTI
3) YGEGY
414
28
392
429
33
396