<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22115

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDTANVGEHIQRSGHNSQNGVSYEPGEGTSLKGSNVFQNGSFHTNGLERSSAHRPDASTVTSVSAKTRELPELFHVTQGFFLFSKLLNRSAQQCWNDLLDMITELAEIQVAPHDSVYASVPIAGKPQDNQSPENIQKKLRVLEFAHAKRAEFIKLLVLSQWGRQAADVSKLIDIQNFIRIRHQAYTGALQYVGDMKKNLVQAQVANPDIRTSLEVLSKGKVASMSDLGYKPPRNLTPKRTLRKLRKINRLLSTRLALHDELPPSFQTYRIHDGRVTFMVPNEFELDLSIGEGSGISQYYFVDIRFLFHPSSSIPKGRIFNELESKVNDVLQTHGLPGCFDLLHNLVLTNKINVLFKQAIEMARGLWADVLRIELLHRTLVVHYWARKPGHKSWVEVGLNRGRRGSKLGASVPPYLGLRWIRDGEQISSGGIDFDTTNLSMERLLRSVIALHITHIISSAYNSIGESLLYSTSALSLRAQLTATEPGNCLLEVQLTETRHLKVSVESMSGTNVFSTTPTALERPDHDRPLDKSSVDDIVTRVARLRCIAAIEEVESYLKMLGFDVINPRALNIDVRRIFPPNILRFSFFSHRLWERNWIVAATSSMDGDSWWIVQFRPGALARRQSAYGVKLGNRSAYRFAQIVRNTFVPSQLEKSYASLADLGHSLSGILTIYANSFYLADLDAIKFYPPVHKLKIEAGSKTPDLSLRYEPAKLPNALRMVLPARIKRQGFVRETIRLTFLGIDPLKNVAIIGAYGRLNIPVKAFSALIRRWDHSLVFQENGNGFAIRLLASTGRPIIVSLIENLQRLECVLSILETLQRKKIEVTSLSLSGISFTYGPKRDFSARLEIGIIRHPSFSEVDAVELASRPDSIFRLELGMQFDSSNPHRRIQRSLASSLNRASAGASMETIAELLKKTLPLMRAFDKLMDNTSRSESLKVQVIVRNAMTYIIHYPDAAVHFRLVARTRSNRLVWVLSDVSNSGPHSGQVSHISTKVQQTLYHAKGEGWRGLGSGVIAELDRVESLLQELHRCVTASRPNSGTAEQSSSKPRKSTAPAEAVVTEPVPRDSSQFAEPGATNSADIIMID
Length1091
PositionTail
OrganismAspergillus homomorphus (strain CBS 101889)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.200
Instability index40.98
Isoelectric point9.65
Molecular weight121868.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22115
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     571.35|     140|     147|     572|     711|       1
---------------------------------------------------------------------------
  368-  519 (154.41/108.05)	.RGLWADV.....LRI...ELLHRTLVVH.YWAR.........KPGHKSWVeVGLNRG...RR..GSKLGASVPpylglrwirdgeqissggidfdttNLSMERLLRSVIALHITHIISSAYNS...IGESL..LYSTSALSLR.A..QLTATE...PGNCllevqltetrhlKV..SVESM.SGTNVFS
  572-  711 (241.12/173.74)	PRALNIDV.....RRIFPPNILRFSFFSHRLWERNWIVAATSSMDGDSWWI.VQFRPGALARR..QSAYGVKLG........................NRSAYRFAQIVRNTFVPSQLEKSYASLADLGHSLSGILTIYANSFYLA..DLDAIKF.YPPVH............KL..KIEAG.SKTPDLS
  720-  863 (175.82/124.27)	PNALRMVLparikRQGFVRETIRLTFLGIDPLKNVAIIGAYGRLNIP...V.KAF..SALIRRwdHSLVFQENG........................NGFAIRLLASTGRPIIVSLIE....NLQRLECVLSILETLQRKKIEVTslSLSGISFtYGPKR............DFsaRLEIGiIRHPSFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.38|      16|     104|     130|     145|       2
---------------------------------------------------------------------------
  130-  145 (29.23/17.19)	KPQDNQSPENIQKKLR
  235-  250 (29.15/17.12)	KPPRNLTPKRTLRKLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.61|      15|      93|     105|     119|       4
---------------------------------------------------------------------------
  105-  119 (26.91/17.30)	DMITELAEIQVAPHD
  199-  213 (26.71/17.12)	DMKKNLVQAQVANPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.79|      37|     571|     316|     352|       5
---------------------------------------------------------------------------
  316-  352 (64.61/47.99)	SSIPKGRIFNELESKVNDVLQTHGLPGCFDLLHN.LVL
  888-  925 (56.18/40.62)	SSNPHRRIQRSLASSLNRASAGASMETIAELLKKtLPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22115 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VMDTANVGEHIQRSGHNSQNGVSYEPGEGTS
2) VTASRPNSGTAEQSSSKPRKSTAPAEAVVTEPVPRDSSQFAEPGATNSA
5
1037
35
1085










Molecular Recognition Features






MoRF SequenceStartStop




1) KPRKSTAPAEAVVTEPVPRD
1053
1072