<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22108

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSKLVSATANESYTWLKELVDKCRSSDLSDTDKKISMLKFLTKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQASDSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRMPKCIEDVGTQHTLTEDQQKPALKKLDMHVRSKLLEVSLPKEFSDIKVSDGTALVRVDGEFKVLLTLGYRGNLSLWRILHLELLVGEKNKPVKLEEVRSHVLGDDLQRRMAATENPFSILYSVLHELCVALVMDTLLRQVQVLRQGRWKDAIKFELITEGGMGHGASSSSVQNPDGESDSPALRTPGIKIIYWLDFDKNASMSDSGACPFIKIEPGSDLQIRCQHSNFVIDPLTGKEADLSLDQSCIDVERLLLRAIFCNRYTRLLEIKRELGKNIQVCRTADDVVLQSCMSEPDIEHDQKEDKCCSKDSEEHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVASSALLECEEALNQGSMTAAEVFISLRSKSILHLFASIGRVLGLQVYEHGFSAVKIPKNILNGSAMVIMAFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSAKDNLFGDLNQVLRNKKIDIGQIQVHENEMNCLVDWGKLCSLLPNAACPNQTSGHEFLSDIQIESSMQIARGHTSGFSSLVDEVFGHERGSSAASFSVQDHSSSLNASLPSHYGSVPMNFRSLKAGTPSPKWEGGMQISQVNNVTKASGVTTHYSGSFFSSGSVKGPFQSGPVASISAGQGRSTAGKRLPASKSEQDLSSLKSPHFIDISSSTAMEEDQLRVLTDTSTDGGSRPSQLLSPSRPTVSRMSVPNSRPNGPHLESFKAAGSSSCVTISQAVESTVNYSTSEDVSSKHDKKSRKRTASDMLNLIPSLQGLENNSRIYKRRNISDLSGSQLSLKQSLISAEMIPKAETYSYGSLIVEANKGNAPSSIYIAALLLVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSASSNIWFRLPSARGDSWQHICLRLGRPGCVYWDVKISDQHFRDLWELQKGSSNTPWGSGVRIANTSDIDSHIHYDPDGVVLSFESVEVDSVKKLVADIQRLANARTFALGMRKLLGTRADEKSEELISSSDVKVSGAKVGTDTSDKLSEQMRKAFKIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSFIPKQTGYLSPQGLLVGSSTTSVGQPTAGPGVNTVMSTASGLTNQTLSMLVAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKHFAVDMRCFAGDQVWLQPATPPKEGCTSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQSGGLANSNNPNSGSGPQQMAANGNRMNLPTSATMSRTGNQVAGLSRAGNALAGSSNLALMTSAVSLRRPPGTIVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFSQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQHPNPAQDELTQTEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGISQAQVGDVVSVQKPRIELCLENHSGLNVDDNSESSSAFKSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVSLRYSFGETPNVAFLGMDGSHGGRACWLHVDDWEKCKQRVARTVEVNGNAAAADISQGRLKLIADSVQRTLHMCIQGQRDSSGVTSSSGAT
Length1809
PositionTail
OrganismLupinus angustifolius (Narrow-leaved blue lupine)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> genistoids sensu lato> core genistoids> Genisteae> Lupinus.
Aromaticity0.06
Grand average of hydropathy-0.174
Instability index44.25
Isoelectric point6.87
Molecular weight197130.13
Publications
PubMed=27557478

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22108
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      15|      16|     675|     689|       2
---------------------------------------------------------------------------
  675-  689 (26.32/17.24)	SVQDHSSSLNASLPS
  693-  707 (27.89/18.80)	SVPMNFRSLKAGTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      17|      18|    1481|    1498|       3
---------------------------------------------------------------------------
 1481- 1498 (28.34/24.10)	Y.GGGWV....PLVaLKKVLRGI
 1501- 1522 (21.88/12.35)	YlGVLWLfsqlPDL.LKEILGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.64|      14|      16|     343|     356|       4
---------------------------------------------------------------------------
  343-  356 (25.96/15.03)	IEP..GSDLQIRCQHS
  360-  375 (18.68/ 8.66)	IDPltGKEADLSLDQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.59|      35|     172|    1171|    1208|       5
---------------------------------------------------------------------------
 1171- 1205 (66.84/34.96)	WESGKEGCTMHVS.P.DQL.WPHTKFLEDFINGGEVSP
 1349- 1377 (34.13/15.06)	....KEGCTSGGSlPcPQF.RP...FIMEHV.AQELNG
 1396- 1429 (48.62/18.47)	PNSGSGPQQMAAN.G.NRMnLPTSATMSR..TGNQVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.09|      22|      23|     873|     894|       9
---------------------------------------------------------------------------
  873-  894 (37.68/21.64)	DKKSR...KRTASDMLNLIPSL.QGL
  895-  920 (27.41/13.71)	ENNSRiykRRNISDLSGSQLSLkQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.87|      74|     188|     519|     654|      11
---------------------------------------------------------------------------
  113-  193 (115.35/49.37)	VYDVP.SAVEI...LLTGSYQRMpKCIEDVGTQHTLTEDQQKpalkklDMHVRSKLLEVSLPKEFSDIKVSDGTALVR...VD.GEFKV
  522-  603 (110.52/144.87)	VYEHGfSAVKIpknILNGSAMVI.MAFPDCGSSYFLLMQLDK......DFKPLFKLLETQPDPSAKDNLFGDLNQVLRnkkIDiGQIQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      10|      22|     308|     319|      12
---------------------------------------------------------------------------
  308-  319 (15.51/15.02)	SDSPAlrTPGIK
  333-  342 (21.30/12.59)	SDSGA..CPFIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.02|      60|     188|     805|     870|      13
---------------------------------------------------------------------------
  805-  870 (92.04/65.15)	STDGGSRPSQLLSPSRPTVSRMSVPNSRPNGPHLESFKAaGSSscvtiSQAVESTVNYSTSEDVSS
 1001- 1060 (111.97/64.11)	SARGDSWQHICLRLGRPGCVYWDVKISDQHFRDLWELQK.GSS.....NTPWGSGVRIANTSDIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.24|      13|      21|    1445|    1457|      18
---------------------------------------------------------------------------
 1445- 1457 (22.95/13.87)	LMTSAVSLRRPPG
 1468- 1480 (22.30/13.24)	LNTAIIGLGDDGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22108 with Med14 domain of Kingdom Viridiplantae
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