<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22090

Description Mediator of RNA polymerase II transcription subunit 11
SequenceMENMIEAPSSLSPPDEAERIRIHEILMNCFNNGILPSKLAPSTVTEGEDCVKVVVNHDIARFQADWLKEHAVSVFFYHETSSLPPGVKSRLITYVASAKQIASWMLMKKESKVTLDNETHTVYFRPWMSEHQLLIWRDLINRDFFWIRCLDVPVSAMGLLKGAVEDAFGSIIRDYAPFKFPVTPDLRDLRFDLALPAKARYKQRLIVDLWEFGSMDIQVACSDTPWCAACRRYFHKSDDNCPKKKKEPRKDQKADEEKSDKGKEDGGGDGEKGLEKEKGKEGEDKGREKEKDDGGKGQKGDGKEEKEQEKAAAEKTDEKTPGPGAENGQGENGGGREKGKERAIKERGKADQKWERVNEKSKAKGTRGKKGRQSPDSTHMLQGEDGLRADQDCSSPRGIENFDYEGKTVWKDLPEPLPQSPRHSKGWDEALSADVGTVFAGNQSTDGILKGLQGGDKSEPSVDPKQTVFTKLSGRKEGFAKPPLKPLIFSGKQCIPKMGTEGTKGNSSGTALQPEGAVGLQSPDSSYELQREDGLRADQDCSSPRGLENSDYEEKIPEEILDFAVAGLFAEGDIQFDPHKDQENVVMCTPSKKAKLDKDSTWPTLQEQYLGEPAGEVALTSLDSLQSVERRIVRTVELAGMVAEELGNPNGPSGPNGPRPDAVTALCKEFMTEIKETQKILREQIKGMCEYRPFENCDYQSRMAAEISLEKLKLVAENLEGMNETAGQYHSLNRDDLIGSAAS
Length743
PositionHead
OrganismChara braunii (Braun's stonewort)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Charophyceae> Charales> Characeae> Chara.
Aromaticity0.06
Grand average of hydropathy-0.820
Instability index41.16
Isoelectric point5.31
Molecular weight82382.51
Publications
PubMed=30007417

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.27|      28|      29|     284|     311|       1
---------------------------------------------------------------------------
  260-  281 (39.70/16.67)	DKG..KE.DGG...GDGEKG...LEKEKGKE
  284-  311 (52.99/24.82)	DKGREKEKDDG...GKGQKGDGKEEKEQEKA
  314-  343 (41.58/17.82)	EKTDEKTPGPGaenGQGENGGGR.EKGKERA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     288.26|      58|     145|     360|     417|       2
---------------------------------------------------------------------------
  360-  416 (104.33/48.54)	.......................KSKAKGTRGKKGR..............QSPDST.....HMLQGE...D.G.LRADQ..DCSSPRGIE.....NFDYEGKTVWKDL.......PEP
  417-  482 (61.16/25.89)	L......................PQSPRHSKGWDEA..............LSADVG.....TVFAGNqstD.GiLKGLQggDKSEP.........SVDPK.QTVFTKLsgrkegfAKP
  499-  559 (70.17/30.61)	............................GTEGTKGNssgtalqpegavglQSPDSS.....YELQRE...D.G.LRADQ..DCSSPRGLE.....NSDYEEK.....I.......PEE
  560-  649 (52.60/21.39)	IldfavaglfaegdiqfdphkdqENVVMCTPSKKAK..............LDKDSTwptlqEQYLGE...PaG.EVALT..SLDSLQSVErrivrTVELAG.MVAEEL.......GNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      11|      20|      48|      58|       3
---------------------------------------------------------------------------
   48-   58 (19.89/16.46)	EDCVKVVVNHD
   69-   79 (20.34/17.00)	EHAVSVFFYHE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22090 with Med11 domain of Kingdom Viridiplantae
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