<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22069

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12
SequenceMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHIMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSNVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLPPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGGGEGGXXXXXXVDPASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTTSNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGPYPGVLPTTMTGVMGLEPNSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRHPRHLGGGAVKTHWAARAHLVGENPCQEQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQHQLSNTQPQPSTNIFGRY
Length1859
PositionKinase
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index52.55
Isoelectric point6.16
Molecular weight205668.24
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22069
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.77|      45|      56|    1628|    1672|       1
---------------------------------------------------------------------------
 1628- 1672 (79.19/46.12)	GSISHLSYRQGPYPGVLPTTMTG...V...MGLEPNSY...KTSVY.RQQQPA....VP
 1686- 1725 (54.94/29.33)	GMLGQSSVHQ.....MTPSSSYG...LqtsQGYTP..Y...VSHVG.LQQHTG.....P
 1727- 1777 (60.20/32.97)	GTMVPPSYSSQPYQSTHPSTNPT...L.....VDPTRHlqqRPSGYvHQQAPTyghgLT
 1778- 1817 (50.44/26.21)	STQRHPRHLGG...GAVKTHWAArahL...VGENPCQE...QPQ...PQSQP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     701|     715|       2
---------------------------------------------------------------------------
  701-  715 (26.85/17.82)	LEQITSFALG.MSYHL
  717-  732 (23.14/14.28)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.99|      19|      19|     492|     510|       3
---------------------------------------------------------------------------
  488-  507 (27.28/15.65)	PAdDSERKEAEGSSSSKLED
  508-  526 (32.71/20.55)	PG.LSESMDIDPSSNVLFED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.80|      17|      56|     949|     965|       4
---------------------------------------------------------------------------
  892-  905 (19.62/12.16)	..SENPANRYS...FVCNA
  910-  926 (19.42/11.93)	CVGHHDPDRVNDiaILC..
  949-  965 (32.76/27.37)	CSSNNGTCGFND..LLCNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      21|      24|    1402|    1424|       5
---------------------------------------------------------------------------
 1402- 1424 (31.02/34.77)	QQTTewAVL.LLEIIISGTV..DMQS
 1427- 1450 (27.14/19.82)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      58|    1227|    1250|       6
---------------------------------------------------------------------------
 1227- 1250 (38.04/23.49)	SLLENIAKATIEVFQQSAETGSSS
 1288- 1311 (39.88/25.00)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.31|      24|      24|     542|     565|       8
---------------------------------------------------------------------------
  542-  565 (42.89/30.77)	EGKGSPSPEKP.DVEKEVK.PPPKEK
  567-  592 (33.43/21.83)	EGTLGVLYDQPrHVQYATHfPIPQEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.56|      13|      17|    1080|    1095|       9
---------------------------------------------------------------------------
 1080- 1095 (15.28/14.45)	DAElkGSGFTvTGGTE
 1099- 1111 (25.28/11.62)	EEE..GGGGS.GGGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.73|      15|      17|    1824|    1838|      10
---------------------------------------------------------------------------
 1824- 1838 (25.17/17.34)	LQQTQQQQQTAALVR
 1844- 1858 (27.56/19.94)	LSNTQPQPSTNIFGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.94|      18|      18|     194|     211|      12
---------------------------------------------------------------------------
  194-  211 (33.14/20.20)	FSDLLM.CPQHRPLVFGLS
  214-  230 (23.69/11.83)	LQTILLcCPS..ALVWHYS
  242-  259 (31.11/18.40)	LDHLPI.APSNLPMPEGNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.56|      16|      26|    1145|    1170|      13
---------------------------------------------------------------------------
 1145- 1170 (18.58/36.86)	RCLkslceDSNDLQDPvlssaQAQRL
 1179- 1194 (29.98/19.54)	RLL.....DNEDGENP.....QRQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.03|      16|      25|    1313|    1328|      14
---------------------------------------------------------------------------
 1313- 1328 (27.47/15.39)	KERDRQKQKSM.SLLSQ
 1340- 1356 (23.56/12.15)	KGQDEQREGLLtSLYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.02|      37|     147|     840|     877|      15
---------------------------------------------------------------------------
  796-  836 (58.19/30.17)	FEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTscshLKSK
  841-  877 (67.83/36.24)	FSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDT....LENP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.70|      16|      24|    1455|    1474|      16
---------------------------------------------------------------------------
 1455- 1471 (22.72/23.86)	SMEEnKRAYMNLVKKLR
 1481- 1496 (26.98/12.50)	SLEK.VRQLLPLPKQTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      22|      25|     319|     342|      17
---------------------------------------------------------------------------
  314-  341 (30.25/26.58)	HsferSDFSNSLDSLCNriFGLGPSKDG
  342-  366 (34.45/22.82)	H.eisSDDDAVVSLLCE..WAVSCKRSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22069 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSNV
3) GEEQQRLLLYPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGPYPG
4) LPTTMTGVMGLEPNSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRHPRHLGGGAVKTHWAARAHLVGENPCQEQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQHQLSNTQPQPSTNIFGRY
5) TVTGGTEELPEEEGGGGSGGGGEGGXXXXXX
6) VLKAAGEELEKGQHLGSSSRKERDRQKQKS
535
475
1567
1644
1089
1293
574
522
1642
1859
1119
1322










Molecular Recognition Features






MoRF SequenceStartStop




1) YWRLDLD
153
159