<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22068

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMCIRAWQERESPTVGSLETILDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVSVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNNSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDMKMEEQTIMAHMGIDSGTNIFDEVDKNDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGPKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACVLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRXNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGNTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLMGQPQQPGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLLQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQPQAGGVVLSPNYSSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLAKEK
Length2118
PositionKinase
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.07
Grand average of hydropathy-0.400
Instability index56.00
Isoelectric point6.91
Molecular weight236663.27
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22068
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     559.32|     118|     120|    1832|    1950|       1
---------------------------------------------------------------------------
 1659- 1753 (127.70/69.27)	.....EPMGS...LIDTkGNKIA....GFDSIDKKQG..LQ........VSTKQKVSPWDLFEGQKN..................................PAPLSWAWFGT.VRVDRKVIKYE.....................eqhhLLLYHTHPMPKPRSYYLEPLPLPP
 1754- 1855 (108.57/57.56)	EEEEEEPTS......P...........VSQEPERKSAEL............SDQG....KTATDEEKKTK...................GRKR...................KTKSSSRVDEYPqsniyrvppnyspissqmlhhpqstLWGYNLMGQPQQPGFFLQNQSLAP
 1856- 1977 (187.06/109.74)	GGSRLDPTGS...FVPT.NTKQA....LSNMLQRRSGAMMQ..PPPLHAITSQQQLLQMKLLQQQQQQRL...................LRQAQARPfQQGPPGDQAALFAAQARPSPQLPQYP.................glqqaqtmPQGYTMYG.TQMP...LQ.QTPQP
 1980- 2113 (135.99/74.35)	GGVVLSPNYSsrtYPAA.HSNPAlmerLRQMQQQPSGYVQQqaSPYLQPLTGSQRLNHQSL...QQSPLVgggidavltsthpslpsvpLPQDPMRP.RQPQVRQQQRLLQMQQPPQPQQPPQP......................qsqTLGLQAM.QPQQP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.80|      27|     203|    1065|    1100|       2
---------------------------------------------------------------------------
 1069- 1100 (43.43/43.24)	SEWLGVLKALCCSSnhvwgFNDVLCTVDVSDL
 1107- 1133 (44.36/21.58)	ATFIAILIARQCFS.....LEDVVQHVALPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.73|      20|     203|    1213|    1239|       4
---------------------------------------------------------------------------
 1213- 1232 (33.56/26.03)	IGNNNVSSLKNDDFTMRGLR
 1241- 1260 (32.17/12.99)	ASQNSKSCGKSISIETANLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.89|      21|     203|     423|     463|       5
---------------------------------------------------------------------------
  435-  461 (33.25/54.52)	CQESTAGvtisrvLHTLEVLDRHCFDR
 1271- 1291 (42.64/15.58)	CQQEWVG......EHCLKEPERLCTDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     417.80|     139|     156|    1340|    1495|       8
---------------------------------------------------------------------------
 1340- 1495 (208.51/170.20)	QWTLRQSWL.ELQLMIKQCLkdpgsgSVAEMNNLLDNIaKATiEVFQQSADLNNNSSNsgmGLFNP...NGIGNTD.........TSST..RQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGrvlkaaGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLV.LTC
 1499- 1653 (209.29/131.92)	QDEQREGLLtSLQNQVNQIL......SNWREERYQDDI.KAR.QMMHEALQLRLNLVG...GMFDTvqrSTQWTTDwallllqiiTSGTvdMHTNNELFTTVLDMLGVLINGTLASDLSNASPG......GSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPkQTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.85|      27|     122|     551|     581|      12
---------------------------------------------------------------------------
  551-  577 (46.68/21.70)	GSSLPVFQNVLLRFLDTQAPSLSDPNS
  674-  700 (50.17/24.22)	GSEFPIFSPMPGESCENANPSLGRRMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     886|     902|      13
---------------------------------------------------------------------------
  886-  902 (22.97/15.64)	LLLKSSSLAGSYtTGLC
  916-  931 (29.21/15.76)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.57|      12|      27|    1137|    1148|      15
---------------------------------------------------------------------------
 1137- 1148 (23.48/12.75)	ACGDADAE....PGAR
 1163- 1178 (18.10/ 8.06)	ACVLPQATgkpfPGIR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22068 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQPQAGGVVLSPNYSSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLAKEK
2) QPGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLLQM
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLH
4) TASTRPRSPAGENVDEHYPKDHDMKMEEQTIM
1906
1843
1742
618
2118
1904
1826
649










Molecular Recognition Features






MoRF SequenceStartStop




1) YWRLDLD
153
159