<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22055

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTSEGPGLLCRWIWVLYFRVLLLPSRVPHLVCLGSCCLPGVPEIGVVAPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAPNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQGQQQTAVPTAQASQIVGSGVQVQPPQPMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length635
PositionTail
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.04
Grand average of hydropathy-0.432
Instability index81.26
Isoelectric point9.29
Molecular weight68647.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22055
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     293.36|      38|      39|     170|     207|       1
---------------------------------------------------------------------------
   71-  104 (40.01/ 7.45)	..AGI..GMPSRGPGQSLGgmGGLGTM..G........Q.PMPLSGQ.....PP
  170-  207 (81.42/23.68)	V.APM..QQPQPPPSQALP..QQLQPM..HHPQHH...Q.PPPQPQQ.....PP
  246-  288 (36.64/ 6.13)	VrTPMvvQQPQVQP.QV....QQVQPQ..GQQQTA...V.PTAQASQivgsgVQ
  289-  324 (48.93/10.95)	V.QP...PQPMPPPPQPSP..QPGQPS..SQPNSNvssG.PAPSP.........
  325-  359 (40.36/ 7.59)	S.SFL..PSPSPQPSQS........PVtaRTPQNF...SvPSPGPLN.....TP
  426-  458 (46.01/ 9.80)	R.CPL..KTLQ.KCEIALE..KLKNDM..AVP......T.PPP.PPV.....PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.57|      44|     126|     460|     503|       2
---------------------------------------------------------------------------
  460-  503 (78.41/42.31)	KQ.QYLCQPLLDAVLANIRSPVF....NHSLYRTFVPAMTAIHGPPITA
  586-  634 (68.16/35.96)	RQwQYDANPFLQSVHRCMTSRLLqlpdKHSVTALLNTWAQSIHQACLSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.99|      13|      21|     209|     221|       3
---------------------------------------------------------------------------
  209-  221 (26.60/12.55)	APNQPSQ.LPPQSQ
  229-  242 (21.39/ 8.23)	APALPGQmLYAQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.94|      27|     398|     141|     167|       6
---------------------------------------------------------------------------
  141-  167 (53.70/27.76)	FRVLLLPSRVP.....HLVC.LGSCCLPGVPEI
  536-  568 (43.24/20.99)	FLVNLDPSHCSnngtvHLICkLDDKDLPSVPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.35|      27|      29|     360|     386|       7
---------------------------------------------------------------------------
  360-  386 (43.85/26.93)	VNPSSVMSPAGSSQAEEQQYLDKLKQL
  390-  416 (43.50/26.66)	IEPLRRMINKIDKNEDRKKDLSKMKSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22055 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAP
2) GVVAPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAPNQPSQLPPQSQTQPLVSQAPALPG
3) MLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQGQQQTAVPTAQASQIVGSGVQVQPPQPMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
69
168
236
123
234
385










Molecular Recognition Features






MoRF SequenceStartStop




NANANA