<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22054

Description mediator of RNA polymerase II transcription subunit 14
SequenceMILLKLFCSQLSSGSPSHLWQKGFIVTCIWSDRKTYGPNEDTFEHERLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIILPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAAEREDTPVMALVLQQFKENIQELVFRTKPGKQPRTGPKRKLSDDPCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPSQQQPFPKQPGSSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1429
PositionTail
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.07
Grand average of hydropathy-0.215
Instability index51.09
Isoelectric point9.00
Molecular weight159154.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22054
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.45|      31|      34|     978|    1011|       1
---------------------------------------------------------------------------
  978- 1010 (50.13/32.56)	......PSqqqPFPK.QP.GSSGAYP.LTSP.PASY...HS....TVNQS
 1042- 1067 (23.89/ 6.58)	.............PT.PP.PSSHGIS.I.GP.GASFaspHG....TLD..
 1068- 1091 (24.10/ 7.54)	P.....SS...PYTMvSPsGRAGNWP..GSP.QVS...............
 1093- 1128 (36.60/16.07)	......PS...PATR.MP.GMSPANPsLHSPvPDAS...HSpragTSSQT
 1130- 1158 (28.73/10.70)	PtnmppPR......K.LP.QRSWAAS.I..P.TILT...HS....ALN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.94|      96|     394|     838|     967|       3
---------------------------------------------------------------------------
  854-  967 (143.24/130.12)	LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDIYcrsrGVVAIRDGAYSLFDNSKLVEGFYPA......PG.....LKTFLNMFVDSNQdarRRSVneddnPPS.......PIGGDM
 1253- 1366 (155.71/76.42)	LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHIM....KLELFPDQATQLKWNVQFCLTIPPSappiapPGtpavvLKSKMLFFLQLTQ...KTSV.....PPQepvsiivPIIYDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.06|      87|     159|     269|     360|       4
---------------------------------------------------------------------------
  269-  360 (144.22/107.01)	N.....................CLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTIKIDENDVSKplqiFHDPPLPA.SDSKL
  399-  513 (124.84/79.88)	NanenssietalpalvvpilepCGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTISSETLQLSN....YSTHPIGNlSKNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      25|    1377|    1386|       6
---------------------------------------------------------------------------
 1377- 1386 (17.56/11.79)	PRQQNSSVAA
 1403- 1412 (19.77/14.43)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.52|      24|      32|     102|     125|       7
---------------------------------------------------------------------------
   70-   88 (22.75/ 9.46)	.LFV....RLLALVKWANNAGKVE
  102-  125 (36.50/19.16)	ILFVDTADRLASLARDALVHARLP
  135-  155 (33.56/17.08)	VLTTGSYPRLPTCIRDKII...LP
  158-  178 (24.71/10.84)	ITKIEKQATLHQL..NQILRHRL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.37|      20|     128|     570|     589|       8
---------------------------------------------------------------------------
  570-  589 (38.54/23.79)	IQELVFRTKP..GKQPRT.GPKR
  696-  718 (28.83/15.72)	VAELVFANCPlnGTSTREqGPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.30|      11|      33|     182|     192|       9
---------------------------------------------------------------------------
  182-  192 (19.25/ 8.96)	DLPPQLANLTV
  217-  227 (20.05/ 9.65)	DVPWRLLKLEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22054 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPSQQQPFPKQPGSSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWA
945
1145










Molecular Recognition Features






MoRF SequenceStartStop




NANANA