<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22053

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTSKATDQIYQRCILTRADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPSLNQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQLHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTMYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKDRQSSEREAIKKHKVEDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGTDDKSSSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTILEGNSSSIGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECVYRQSWTVGKLELLPSGPAVPFVKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPPQMTSTGNASTPSATLASAASSTMTMTSGVAMSSSVATANSTLTTTSTSSSSSNLNSGVSSNKLPSFPPFGSMNSSGTGSMPTQVSTVQNGQLGGQQSSALQTAGISGESSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2166
PositionMiddle
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.08
Grand average of hydropathy-0.410
Instability index52.56
Isoelectric point5.46
Molecular weight238940.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.93|      36|      38|    1465|    1502|       1
---------------------------------------------------------------------------
 1465- 1500 (61.70/33.29)	SSLLSQPNLVAPTSQ.SLITPPQMTSTGNASTPSATL
 1505- 1539 (48.82/25.90)	SSTMTMTSGVA.MSS.SVATANSTLTTTSTSSSSSNL
 1869- 1899 (41.63/18.42)	SSLLSRRNL.QSLSK.RLKDMCRMCGISAADSP....
 1900- 1934 (44.77/23.72)	.SILS.ACLVAMEPQgSFVIMPDSVSTGSVFGRSTTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1088.34|     275|     713|     818|    1096|       2
---------------------------------------------------------------------------
  286-  550 (353.79/162.93)	............PTPSSVGSSHCSAS...CLGVHQVPASTRDPAMSSVT.LTPPTSPEEVQ......TVD.....PQ.SAQkwVK.FSSVSDGFNSDSTSHHGGKIP.RKLANHVVD..RVWQECNMnraqnkrKYSASSGGLseEEIPD.....KVASwDFV.EATQRTNC.....SCLRHKNLKPRNPGQQG....QAPSLN.QQQQVLPKHKTnekqEKSEKPqKRPLTPFHHRVS..VSDDVGMDTDSAS.QRLVIS...APDSQVRFSNIRTNDVAKTPQLHG..TEMANSPQPPPLSpHPCDVVDEGVTKTPSTP
  556-  798 (264.19/119.62)	YQMPTPD..PLVPSKP.MEDRIDSLSqsfPAQFQEAVEPTMYV..GTAVnLEEDEANIAWKyYKVpkKKDVEFLPPQlPSD.kFKD.....DPVG...PFGQESVTSVTELMVQCKKPLKVSDELVQ.......QYQIKNQYL..SAIASdaeqeSKID.PYAfVEGDEEFLfpdkkDRQSSEREAIKKHKVEDGPSSVTVLSHeEDAMSLFSPSI....KQ.DAP.RPASHARPPSTSLIYDSDLAVSYTDLDnLFNSDEdelTPGSKKSAN................................................
  818- 1096 (470.36/228.24)	SCISTADlhKMYPTPPSLEQHIMGFS...PMNMSNKEYGSMDITPGGTI.LEGNSSSIGTQ.FKI..EVDEGFCSPK.PSE..IKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECVY.......RQSWTVGKL..ELLPS.....GPAV.PFV.KEGDGSTI.....DQEYGPAYTPQTHTSFGMPPSSAPPSN.SGAGILPSPST....PRFPTP.RTPRTPRTPRAGGPASAQGSVKYENSD.LYSPAS...TPSTCRPLNSVEPATVPSIPEAHSlyVNLILSESVMNLF.KDCNFDSCCICVCNMNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      13|      37|    1246|    1258|       3
---------------------------------------------------------------------------
 1246- 1258 (24.87/12.86)	DEALVKSSCLHPW
 1284- 1296 (24.03/12.19)	QDAIQKKRTVRPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.86|      19|      40|    1131|    1149|       4
---------------------------------------------------------------------------
 1102- 1118 (26.57/13.52)	..GV....YIPDPMQEAQYRCTC
 1131- 1149 (32.10/17.96)	NSGL....FLEDELDIIGRNTEC
 1169- 1190 (26.19/13.22)	NGGLkeseKFPDEL.ILLLQDQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.33|      53|     397|    1602|    1706|       5
---------------------------------------------------------------------------
   92-  149 (86.18/31.70)	HDLSEEEDGVWENGLsYECrtllFKAVHNLLERCLMNRNFVRIG..KWFVKPYEKDEKPI
 1644- 1698 (86.15/25.83)	KDESTNSSNVWTLGL.LRC....FLEMVQTLPPHIKSTVSVQIVpcQYLLQPVKHEDRQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.50|      25|      40|    1396|    1420|       6
---------------------------------------------------------------------------
 1396- 1420 (43.53/24.58)	GQHRPISRL.LTDGIMR..VGS.TASKKL
 1435- 1463 (30.97/15.49)	GNNEAFSKLkLYAQVCRydLGPyLASQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.80|      48|    1362|     209|     260|       9
---------------------------------------------------------------------------
  209-  260 (72.56/58.45)	NGTLTGQafKMSDSATKKLIGEWK...QFYPISScLKEMSEEKqEDMDWEDDSLA
 1574- 1624 (80.24/48.09)	NGQLGGQ..QSSALQTAGISGESSlptQPHPDVS.ESTMDRDK.VGIPTDGDSHA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22053 with Med13 domain of Kingdom Metazoa
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