<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22039

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQGGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGXGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQSKREKSDKEKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1573
PositionMiddle
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.04
Grand average of hydropathy-0.690
Instability index53.84
Isoelectric point8.91
Molecular weight167531.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22039
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     455.84|      49|      50|     969|    1017|       1
---------------------------------------------------------------------------
  724-  766 (40.99/ 8.75)	F......DV.NMTADT....LD.T.P...HITPAPSQC..S..TPP....T.....TYPQPVPHPQPSIQRM
  770-  818 (35.82/ 6.50)	S......SS.DSIGPDvtdiLS.DIAEEASKLPST.....SDDCPPigtpV.....R.....DSSSSGHSQS
  884-  926 (41.02/ 8.76)	D......ES.SQSGDN....DD.FK.GFASQALNTLG.......VP....M.....LGGDNGETKFKGNSQA
  975- 1017 (70.89/21.74)	.............GPG....LD.SKPGKRSRTPSNDGK..SKDKPP....K.....RKKADTEGKSPSHSSS
 1023- 1073 (46.57/11.17)	P......PT.STGG.......S.KSPGSSGRSQTPPGV..ATPPIP....KitiqiPKGTVMVGKPSSHSQY
 1075- 1121 (50.31/12.80)	S......SG.SVSSSG.......SKSHHSHSSSSSSSS..SASNSG....K.....MKSSKSEGSSSSKLSS
 1130- 1172 (40.83/ 8.68)	SgssqskNS.SQSG.........GKPG..SSPITKHGL..SSGSSS....T.....KMKP..QGK.PS.S..
 1175- 1221 (46.51/11.14)	.......NP.SLSKPN....IS...P.SHSRPPGGSDKlaSPMKPV....P.....GTPPSSKAKSPISSGS
 1262- 1298 (43.09/ 9.66)	S......SSfSSSGSS....MS.SSQNQH.......GS..SKGKSP....S.....R......NKKPSLTAV
 1355- 1399 (39.81/ 8.23)	S......KV.STSGGS....VDsSKKTSESKNVGSTGV..AKIIIS....K.....H...D..GGSPSIKAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.41|      48|     160|      52|     108|       2
---------------------------------------------------------------------------
   52-  108 (65.36/60.93)	SGGH....QHLVSCLETLQKalKVTSlPAMTDRlESIARQNGLGSHLSASGtecyiTSDMF
  215-  266 (80.05/46.30)	SGGHlmnlKYYASPSDLLDD..KTTS.PIILHE.NNVPRSLGMNASVTIEG.....TSAMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     262.86|      50|      50|     324|     373|       3
---------------------------------------------------------------------------
  272-  322 (35.72/14.43)	....PLI........MgSHPVdnkWTPSF.SSITsansvdlpaCFFL.KFPQPIPVSRA.................F...VQKL...Q..
  324-  373 (95.11/50.56)	CTGIPLF........E.TQPT...YVPLY.ELIT.........QFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  383-  424 (34.62/13.76)	...................PD...GRSLQgTLVS.........KITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  434-  489 (52.33/24.53)	SPGLLQF........E.V.......CPLS.E..S.........RFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
  501-  547 (45.08/20.12)	CMSIPVTmrairrkaE.TIQA...DTPAL.SLIA...........ETVED....MVKKNL...............P....PASSPG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.90|      16|      19|    1483|    1498|       5
---------------------------------------------------------------------------
 1483- 1498 (25.78/16.22)	EYSTEKHKKHKKEKKK
 1501- 1516 (26.12/16.52)	DKDRDRDRDKDRDKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.61|      15|      19|     662|     676|       6
---------------------------------------------------------------------------
  662-  676 (26.55/12.21)	GSSPLERQNSSSGSP
  683-  697 (26.06/11.83)	GSNKTKKKKSSRLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.39|      30|      64|     549|     596|       8
---------------------------------------------------------------------------
  549-  578 (48.67/19.13)	...................GMTTGNNPMSGTTTPTNTFPGGPITTLFnM
  596-  635 (31.92/28.29)	SkvsqnpiltsllqitgngGSTIGSSP....TPPHHTPP..PVSS...M
  636-  661 (41.81/ 9.38)	A..................G.NTKNHPMLMNLLKDN..PAQDFSTLY..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.37|      12|     184|    1235|    1246|      21
---------------------------------------------------------------------------
 1235- 1246 (22.95/ 9.57)	MKSSSGLGS...SGS
 1417- 1431 (18.42/ 6.05)	MASSKNYGSpliSGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22039 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSIISVAGKALGPADLMEHHSGXGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQSKREKSDKEKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQGGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTV
931
538
575
1573
571
929










Molecular Recognition Features






MoRF SequenceStartStop




1) YRLPPI
636
641