<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22036
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MELHALSACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLLISLCHSSNDKKSQKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFREVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 645 |
Position | Head |
Organism | Ursus maritimus (Polar bear) (Thalarctos maritimus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.426 |
Instability index | 55.00 |
Isoelectric point | 6.73 |
Molecular weight | 72246.48 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP22036
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 195.90| 51| 110| 274| 324| 1
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274- 324 (87.77/49.65) PLPKSKP.GSPHW...QTKLEAAQNVLL........CKEIFAQLSREAV..QIKSQIPHIVVKNQ
387- 437 (68.50/37.31) PHPASAPfG..HK...RMRLSGPQ.AFD........KNEINSLQSSEGLleKIIKQAKHIFLRSR
448- 497 (39.62/18.82) RIEDPQI..QAHWsniNDVYESSVKVLItsqgyeqiCKSIQLQLNIGVE..QIR...........
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 214.48| 70| 339| 169| 242| 2
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169- 242 (111.22/104.21) QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHH..GTFEVIKNTDIDLDKKI.....PEDYCPLDVQIP
511- 591 (103.27/78.33) QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGLGPIEsiGNASAITVASPSGDYAIsvrngPESGSKIMVQFP
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