<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22029

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMKSSSVLSSQYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKAPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWTTQLPPRAPLPVAKRKRDREGHVFREKWERAYFFVEVKSMPMCLICKKIVSVLKEYNLRRHYESKHSKSFDQYTEQMRDAILSELKKGLKCQ
Length745
PositionUnknown
OrganismUrsus maritimus (Polar bear) (Thalarctos maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ursus.
Aromaticity0.06
Grand average of hydropathy-0.336
Instability index58.73
Isoelectric point9.54
Molecular weight79356.57
Publications
PubMed=24813606

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22029
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     261.53|      26|      26|     261|     286|       1
---------------------------------------------------------------------------
  181-  202 (34.78/ 6.89)	GGG..sAPG...PL......Q...P.....K...QPVP......L.PPAPP
  261-  283 (48.86/13.08)	...QA.APGVGPPF......S...Q.....A...PAPP......L.PPGPP
  284-  312 (35.45/ 7.18)	GAPKA.PPASQPSL....vsT...V.....A...PGPG......LaPPAQP
  509-  545 (34.06/ 6.57)	GAQQA.PPGLGPILedqarpS...QnllqlR...PPQP......Q.PQGTV
  546-  571 (38.51/ 8.53)	GASA..ASG.QPQP......QgaaQ.....A...P.PG......A.PQGPP
  584-  611 (34.85/ 6.92)	LRPQN..PGANPQL......R...S.....LllnPPPP......Q.TGVPP
  632-  662 (35.02/ 7.00)	HQGLG.QPQLGPPL..........L.....H...PPPAqswttqL.PPRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.82|      26|      26|     421|     446|       3
---------------------------------------------------------------------------
  421-  446 (45.78/37.03)	VQF.HFTNKDLESLKGLYRIMGNGFAG
  448-  474 (39.04/30.44)	VHFpHTAPCEVRVLMLLYSSKKKIFMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.68|      13|      16|     315|     327|       4
---------------------------------------------------------------------------
  315-  327 (22.65/12.54)	PSMAGTVAPGGVS
  331-  343 (22.04/11.95)	PAQLGAPALGGQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22029 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKAPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWTTQLPPRAPLPVAKRKRDREG
182
494
340
674










Molecular Recognition Features






MoRF SequenceStartStop




NANANA