<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22011

Description cyclin-dependent kinase 19 isoform X2
SequenceMISRRSWRRSGSGWRICLSTKGAKWDAAPTGTSTRRGEKMVSCPKKECTLSCRVYHTSLSEIPGGLRVWTSSVGGSRLFSRRKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHPQPAAPPQQAAAPPQAAPQQQNSTQANGTAGGAGAGPGAAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSSLGYSSSSQQSAQYHPSHQAHRY
Length541
PositionKinase
OrganismBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti> Balaenopteridae> Balaenoptera.
Aromaticity0.08
Grand average of hydropathy-0.644
Instability index62.19
Isoelectric point9.38
Molecular weight60772.28
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22011
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.31|      28|      41|     472|     499|       1
---------------------------------------------------------------------------
  431-  464 (28.22/12.41)	..PPQAAPQQqnstqanG.TAGGAGAGPgAAGAGLQH
  472-  499 (52.75/29.81)	QVPPNKKPRL.......G.PSGTNSGGP.VMPSDYQH
  511-  539 (40.34/21.01)	QGSSQSQSSL.......GySSSSQQSAQ.YHPSHQAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|     190|     204|       2
---------------------------------------------------------------------------
  190-  204 (26.77/17.86)	DLKPANILVMGEGPE
  228-  242 (28.67/19.62)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.61|      28|      41|     353|     380|       3
---------------------------------------------------------------------------
  353-  380 (48.12/27.56)	KLLTMD.PTKRITSEQALQDPYFQEDPLP
  396-  424 (45.49/25.67)	EFLNEDePEEKGDKNQQQQQNQHPQPAAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22011 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHPQPAAPPQQAAAPPQAAPQQQNSTQANGTAGGAGAGPGAAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSSLGYSSSSQQSAQYHPSHQAHRY
353
502










Molecular Recognition Features






MoRF SequenceStartStop




1) QSSLGYSSSSQQSAQYHPSHQAHRY
2) RLNYQSSVQ
3) VPPNKKPRLGP
478
464
434
502
472
444