<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22009

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPVSSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWITFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNLNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPTLSQQPQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKNLEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKTLKVSDELVQQYQIKNQYLSAVASDSEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKVEDVPSSVTVLSHEEDAMSLFSPSVKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSGCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPTIKLSEECIYRQSWTVGKLELLPSGPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVTNNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDFDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNSEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQPLITPPQMTSTGNANTPSATLASTASSTVTMTSGVAMSSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHVKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti> Balaenopteridae> Balaenoptera.
Aromaticity0.08
Grand average of hydropathy-0.398
Instability index52.77
Isoelectric point5.40
Molecular weight239348.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22009
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     337.27|      98|     320|     473|     599|       1
---------------------------------------------------------------------------
  493-  591 (175.09/113.46)	ASQRLvISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDV.VDEGVTKTPSTPQ..SQHFYQMP.TP....DPLVPSKPIE.DRIDSLS.QSFPAQFQ
  975- 1052 (88.16/35.30)	........................AYTPQTH....ASFGMPPSSAP.PSN..SGAGILPSPSTPRfpTPRTPRTPrTPrgagGPASAQGSVKyENSDLYSpASTPSTCR
 1465- 1525 (74.02/25.11)	ASQPL.DSSLLSQPNLVAPTSQPLITPPQMTSTGNANTPSATLASTASSTVtMTSGVAMSSS...............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.52|      16|      28|    1096|    1111|       2
---------------------------------------------------------------------------
 1096- 1111 (31.84/20.95)	CVCN....MNIK.GADVGVYI
 1122- 1142 (22.68/12.58)	CTCGfsavMNRKfGNNSGLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.31|      28|     534|    1225|    1310|       3
---------------------------------------------------------------------------
  773-  800 (48.92/ 6.92)	DSDLAVSYTD..LDNLFNSDEDE.......LTPGSKK
 1231- 1267 (43.39/114.92)	DCYLALEHGRqfMDNMSGGKVDEalvksscLHPWSKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.99|      19|     534|    1292|    1310|       4
---------------------------------------------------------------------------
 1292- 1310 (37.08/21.97)	AIQKKRTVRPWGVQGPLTW
 1828- 1846 (35.90/21.03)	ARRKKGSARRFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.53|      90|     257|     601|     704|       5
---------------------------------------------------------------------------
  601-  704 (122.13/118.92)	GTAvnLEEDEANIAWKyYKVPKKKNleFLPPQlPSDkFKD.....DPVG...PFGQESVTSVTELMVQCKKTLKVSDELVqqYQiknQylSAVASDSEQEPKIDPYAFV.EGD
  866-  964 (148.40/93.70)	GTV..LEGNSSSIGAQ.FKIEVDEG..FCSPK.PSE.IKDfsyvyKPENcqvLVGCSMFAPLKTLPSQCLPTIKLSEECI..YR...Q..SWTVGKLELLPSGPTMPFIkEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.61|      65|     321|    1617|    1681|       6
---------------------------------------------------------------------------
 1617- 1681 (116.40/66.02)	MDRDKVGIPTDGD.SHAITYPPAIVVYIIDP.FTYENKDESTNSSNVWTLGL.LRCFLEMVQTLPPHV
 1944- 2011 (98.21/54.54)	MQTSQLNTPQDTScTHILVFPTSASVQVASAtYTTENLDLAFNPNNDGADGMgIFDLLDTGDDLDPDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     549.77|     172|     263|      17|     211|      10
---------------------------------------------------------------------------
   17-  211 (281.33/218.79)	CnlFCLADLTGIKWKRYVWQGPTSAPIL....FPVTEEDPILSSFSRCLKADVLGVWRRDqrPGRRELWIFWWGEDPNFA..DLIHH......DLSEE.EDGVWEnglsyECrtllfkavHnlLERCLMNRNFVRIGKWFVKPYEKDEKP....INKSEHLSCSftFFLHGDSNVCTSVEINQ.....HQPVYLlsEEHITLAQQ..SNSPFQVILSPF
  281-  476 (268.44/161.02)	C..FVLVPQSDIPTPSSVGSSHCSASCLgvhqVPASTRDPAMSSVTLTPPTSPEEVQTVD..PQSAQKWITFSSVSDGFSsdSTSHHggkiprKLANHvVDRVWQ.....EC........N..LNRAQNKRKYSASSGGLCEEETADKVAswdfVEATQRTNCS..CLRHKNLKPRNPGQQGQaptlsQQPQVL..PKHKTNEKQekSEKPQKRPLTPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.59|      28|     451|     721|     759|      11
---------------------------------------------------------------------------
  721-  750 (38.08/21.90)	EAGKKHKvEDVPSSVtVLSHEEDAMSLFSP
 1175- 1202 (47.51/19.97)	NGGLKES.EKLPDEL.ILLLQDQCTNLFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.94|      23|      37|    1756|    1779|      12
---------------------------------------------------------------------------
 1756- 1779 (38.36/29.56)	CIRlYTPPFILAPVKDKQTELGET
 1795- 1817 (43.59/28.97)	CLS.HDQRWILASCTDLYGELLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.08|      12|      18|    1572|    1588|      13
---------------------------------------------------------------------------
 1572- 1588 (15.68/21.50)	MSTQASTVqngqlGGQP
 1597- 1608 (21.40/11.96)	ISGESSSI.....PTQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22009 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKNLKPRNPGQQGQAPTLSQQPQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDR
2) DLDNLFNSDEDELTPGSKKSANGSDDKSGCKESKT
3) EDAMSLFSPSVKQDAPRPTSHARPPSTSLI
4) GPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
5) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
6) SSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPTQPHPDVSESTMDRDKVGIPTDGD
7) VAPTSQPLITPPQMTSTGNANTPSATLASTASS
424
782
742
954
2021
1523
1480
578
816
771
1039
2052
1629
1512










Molecular Recognition Features






MoRF SequenceStartStop




NANANA