<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22007
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGADGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRGALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLHVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKSATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSSEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPNGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 651 |
Position | Head |
Organism | Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti>
Balaenopteridae> Balaenoptera.
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Aromaticity | 0.06 |
Grand average of hydropathy | -0.427 |
Instability index | 53.91 |
Isoelectric point | 7.33 |
Molecular weight | 72802.11 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP22007
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 175.05| 50| 110| 280| 330| 1
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280- 330 (83.70/51.82) PLPKSKP.GsPHW...QTKLEAAQNVL........LCKEIFAQLSREAV..QIKSQIPHIVVKNQ
393- 443 (70.26/39.12) PHPASAPfG..HK...RMRLSGPQ.AF........DKNEINSIQSSEGLleKIIKQAKHIFLRSR
462- 503 (21.09/ 6.79) ..........AHWsniNDVYESSVKVLitsqgyeqICKSIQLQLNIGVE..QIR...........
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 212.97| 70| 339| 175| 248| 2
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175- 248 (111.99/83.02) QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHH..GTFEVI....KNTDIDLD.KKIPEDYCPLHVQIP
517- 597 (100.98/60.47) QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGLGPIEsiGNASAItvasPNGDYAISvRNGPESGSKIMVQFP
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