<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21998

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMVFQCWLCPVPVLAEQASLFSSANRHEDTRLPSASELDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDGPNLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENADENYPKDHDAKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTESGGGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSTRSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYAQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLLGQPQQPSLFLQSQALTPGGSRLEPAGSFVPTNTKQALSNMLQRRSGAGMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQPGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPAVSLSQDPVRPRQPQVRQQQRLLQMQQPRQPSQPQGQTLGLQTVQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2175
PositionKinase
OrganismBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti> Balaenopteridae> Balaenoptera.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index56.28
Isoelectric point7.08
Molecular weight242789.59
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21998
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     346.32|     131|     156|    1824|    1979|       1
---------------------------------------------------------------------------
 1824- 1879 (22.71/23.82)	.................................................................................................................YaqsNMY..RVPPNYSPvssqmMHHPQSTLWG..YN..................LLGQPqQPSLFLQSQAlTPggsRL
 1880- 2045 (205.30/108.28)	EP.AGSfvptntkQALSNM.LQRRS..GAGMQP......PSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRpfQQGQPGDQAALFAAQArpsPQLPQYP..GLQQAQTMPQgY...TMYgtQMPLQQTP.....QQQPGSVVLSptYNsrtypaahsnpalmerlrQMQQP.PPSGYVQQQA.SP...YL
 2046- 2145 (118.31/45.77)	QPlSGS.......QRLNHQsLQQSPlvGGGLDAvltsvhPNLPAVSLSQDPVRPRQPQVRQQQRLLQMQQPR..QPSQPQGQTLGLQTVQ...PQQPLFPrqGLQQTQQQQQ...............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     409.30|     139|     156|    1124|    1279|       2
---------------------------------------------------------------------------
 1124- 1279 (202.43/136.39)	ATFIAILIARQcfslEDVVQH.VALPSLLaaaCGDAD..AEPG.ARMTCRLLLHLFRAPQAclLPQAT.GKPFPgiRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAkiGSNNVSSLKN..DDF...TMRGLRRDGnadDIWTASQNSkSCG....KSI.SIETANLR
 1282- 1435 (206.87/102.99)	ARYVLRTICQQ....EWVGEHcLKEPERL...CTDKEliLDPVlSNMQAQKLLQLICYPHG..IKECTeGDNLQ..RQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDP..GSGSVAEMNNllDNIakaTIEVFQQSA...DLNNNSSNS.GMGlfnpNGIgSTDTSSTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.10|      31|      82|     720|     750|       3
---------------------------------------------------------------------------
  720-  750 (51.85/35.63)	GEKLLKREKPRELIFPSNYDLLRHLQYATHF
  774-  798 (29.76/16.85)	KE....REEARHQLKKITKDILKILNKKS..
  805-  835 (46.50/31.07)	GDEGQKARKSKQEAFPTLETVFTKLQLLSYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.93|      52|      92|      75|     132|       4
---------------------------------------------------------------------------
   75-  124 (58.90/54.69)	............................................AYFSSILAEKLKLNTFQDTGKKKPQVNAKdnyWLvtaRSQSAIHSWFSDL
  125-  212 (69.03/45.70)	AGNKPLAIlakkvpilskkedvfaylakysvpmvratwlikmtcAYYSAISEAKIKKRQATDPNLEWTQISTR...YL...REQLAKISDFYHL
  216-  247 (26.00/10.18)	AGDGPVPV..............................ppdveqAMRQWEYNEKLAFHMFQE................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.75|      45|     121|     549|     593|       7
---------------------------------------------------------------------------
  549-  593 (72.77/47.06)	GESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNS
  673-  717 (80.98/53.34)	GTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANPSLGRRMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.80|      60|     156|    1450|    1514|       8
---------------------------------------------------------------------------
 1450- 1511 (92.98/58.15)	GVWLVAPLIARLPTSVQGRvlKAAG.EELEKGQHLGSSSKKERDRQK.........QKSMSLLSQQPFLSLV
 1613- 1668 (82.49/45.44)	GVLINGTLASDLSNASPG......G.SEENKRAYMNLVKKLKKELGD.........KRSESIDKVRQLLPLP
 1673- 1731 (65.33/42.10)	DVITCEPMGSLIDT..KGN..KIAGfDSIDKKQGLQVSTK.....QKvspwdlfegQKNPAPLSWAWF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.05|      25|      86|     989|    1013|      10
---------------------------------------------------------------------------
  989- 1013 (47.17/32.69)	FSS...ACSKVKQTIYNNVIPA...NSNLRW
 1073- 1103 (37.88/24.67)	FSSeltACCTVLSSEWLGVLKAlccSSNHVW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21998 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQPGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVL
2) PSLFLQSQALTPGGSRLEPAGSFVPTNTKQALSNMLQRRSGAGMQPPSLHAITSQQQ
3) RSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYAQSNMYRVPPNYSPVSSQMMH
4) SVHPNLPAVSLSQDPVRPRQPQVRQQQRLLQMQQPRQPSQPQGQTLGLQTVQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
5) TASTRPRSPAGENADENYPKDHDAKMEEQTIMA
1925
1863
1761
2075
634
2073
1919
1845
2175
666










Molecular Recognition Features






MoRF SequenceStartStop




1) YLEPL
1764
1768