<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21991

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPSGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGGFEVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSSYKTPVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHSSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQHSVFHLPFSPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2073
PositionKinase
OrganismBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti> Balaenopteridae> Balaenoptera.
Aromaticity0.07
Grand average of hydropathy-0.431
Instability index53.14
Isoelectric point6.64
Molecular weight230517.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.44|      23|      24|    1691|    1713|       2
---------------------------------------------------------------------------
 1682- 1699 (32.53/16.19)	PRAYYLE.....PLPLPPEDEEP
 1700- 1720 (38.25/20.68)	PAPALLEPEKKAPEP..PKTDKP
 1806- 1820 (25.57/10.71)	YRPVRL.PMQK..LP.....TRP
 1821- 1843 (33.10/16.64)	PYPGVLPTTMTGVMGLEPSSYKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.50|      22|      24|    1904|    1925|       3
---------------------------------------------------------------------------
 1904- 1925 (46.29/24.99)	HTGPAGTMVPPSYSSQ..PYQSTH
 1927- 1948 (29.88/13.14)	STNP..TLVDPTRHLQqrPSGYVH
 1952- 1973 (34.33/16.35)	PTYGHGLTSTQRFSHQ..TLQQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.38|      19|      24|    2014|    2036|       4
---------------------------------------------------------------------------
 2027- 2049 (27.89/17.89)	LpfSPQFQRQglQQTQQQQQTAA
 2050- 2069 (27.49/ 6.39)	L..VRQLQQQ.lSNTQPQPSTNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.07|      13|      16|     811|     826|       5
---------------------------------------------------------------------------
  811-  823 (24.77/19.31)	MSYHLPLVQHVQF
  828-  840 (21.31/ 6.73)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|     975|     987|       6
---------------------------------------------------------------------------
  975-  987 (25.11/16.31)	ENPAA.HTFTYTGL
  993- 1006 (21.03/12.38)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.14|      59|     125|    1450|    1511|       7
---------------------------------------------------------------------------
 1450- 1509 (99.87/78.83)	SLySQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTV......Q..RST.QQTTEWAVLL
 1579- 1636 (68.15/45.18)	SL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKIAG.FDSIfkkeglQ..VSTkQKISPW....
 1638- 1672 (37.11/21.33)	...........................LFEGLKPSAPLSWGWFGTV......RvdRRV.ARGEEQQRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.89|      23|     125|    1752|    1784|       8
---------------------------------------------------------------------------
 1752- 1784 (34.51/39.96)	MGPgrSGPYGVtvppdllhHTNPG...SISHLSYRQ
 1878- 1903 (38.38/19.54)	MTP..SSSYGL........QTSQGytpYVSHVGLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.51|      17|      18|     638|     655|       9
---------------------------------------------------------------------------
  638-  655 (25.40/19.20)	FDDPADDpERKEAEGSSS
  658-  674 (30.11/17.22)	LEDPGLS.ESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.35|      14|      27|    1108|    1121|      10
---------------------------------------------------------------------------
 1108- 1121 (27.16/17.54)	CSEQDSEP..GARLTC
 1136- 1151 (23.19/13.64)	CQSDGNKPtvGIRSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.17|      17|     148|    1857|    1876|      11
---------------------------------------------------------------------------
 1860- 1876 (31.44/20.78)	RQQLQQSQGMLGQSSV.H
 2009- 2026 (28.74/10.49)	QQQQQQQQQQQQQHSVfH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.12|      19|      19|     335|     353|      12
---------------------------------------------------------------------------
  335-  353 (37.17/21.71)	PQP.PTSSTPSTPFSDLLM.C
  354-  374 (26.95/13.35)	PQHrPLVFGLSCILQTILLcC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      15|    1276|    1290|      14
---------------------------------------------------------------------------
 1276- 1290 (22.26/17.20)	HRLLDNEDgENPQRQ
 1293- 1306 (25.76/14.81)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.39|      13|      24|    1510|    1522|      15
---------------------------------------------------------------------------
 1510- 1522 (23.26/14.91)	LEIIISGTV..DMQS
 1534- 1548 (18.13/ 9.99)	LSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      24|    1023|    1033|      18
---------------------------------------------------------------------------
 1023- 1033 (21.19/12.90)	AILCAELTGYC
 1046- 1056 (22.77/14.49)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      22|      26|     472|     495|      19
---------------------------------------------------------------------------
  467-  494 (30.25/23.15)	HsferSDFSNSLDSLCNriFGLGPSKDG
  495-  519 (34.45/19.87)	H.eisSDDDAVVSLLCE..WAVSCKRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      16|      17|    1178|    1193|      20
---------------------------------------------------------------------------
 1178- 1193 (28.25/15.89)	LGDAE.LKGSGFTVTGG
 1197- 1213 (24.57/12.81)	LPEEEgGGGSGGRRQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.02|      65|     338|     190|     259|      21
---------------------------------------------------------------------------
  190-  259 (109.04/76.46)	IITKYLwEQLQKMAEYYRPGPS......GSGGCGS...TIGPLPHDVevaIRQWdYNEKLAMFMFQDGMLDRHEFLTWV
  525-  598 (98.99/54.73)	VVAKLL.EKRQAEIEAERCGESeaadekGSIASGSlsaPSAPIFQDV...LLQF.LDTQAPMLTDPRSESERVEFFNLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21991 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSSYKTPVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHSSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQHSVFHLPFSPQFQRQGLQQT
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLG
3) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
1684
688
628
15
2041
724
675
61










Molecular Recognition Features






MoRF SequenceStartStop




1) IFGRY
2) MAAFGI
2069
1
2073
6