<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21987

Description mediator of RNA polymerase II transcription subunit 14
SequenceMFQVMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCRQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPVLALLLQQFKENIQELVYRTKNGKQPRSSTKRKLSEGLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHFMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSAAPPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length993
PositionTail
OrganismBalaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Mysticeti> Balaenopteridae> Balaenoptera.
Aromaticity0.07
Grand average of hydropathy-0.277
Instability index58.58
Isoelectric point9.29
Molecular weight109963.56
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21987
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     236.89|      45|      46|     591|     635|       1
---------------------------------------------------------------------------
  525-  559 (57.60/20.24)	.......................SPIGGDMMDS.LIS.QL.Q..PPPQQQPFPKQPGSSGAYP
  568-  626 (74.44/28.20)	HSTVNQSPSmmhtqspgnlhaasSPSGALRAPS.PAS.FVPT..PPPSSHGISIGPGASFASP
  627-  671 (60.90/21.80)	HGTLDPSSP..........ytmvSPSG..RAGNwPGSpQVSG..PSPATR....MPGMSPANP
  674-  711 (43.96/13.80)	H......SP........vpdashSP....RAGT.SSQ.TMPTnmPPPRKL.....PQRSWAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     421.28|     138|     489|     327|     497|       2
---------------------------------------------------------------------------
  327-  497 (215.35/165.20)	PDIPTHLNIFSEVRV....YNYRKLI............L..CYGTTK.....GSSISIQWNSihqKFHISLGTVGPNSGCSNchntilhqlqemfnkTPNVVQLLQVLF..........DTQAPLNAInklptVPML.....GLTQRTNTAYQcfsilpQSSThirlAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSK.LVEGFYPAPG
  814-  990 (205.94/105.82)	PDELQVLEKFFETRVagppFKANTLIaftkllgapthiLrdCVHFMKlelfpDQATQLKWNV...QFCLTIPPSAPPIAPPG...............TPAVVLKSKMLFflqltqktsvPPQEPVSII.....VPIIydmasGTTQQADIPRQ......QNSS....AAPPMMVSNILKRFAEMNPPRQGECTIFAAVRdLMANLTLPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.05|      30|     706|      35|      68|       4
---------------------------------------------------------------------------
   35-   68 (48.37/49.09)	LKFWLGQQRCRqsiKHL.PTISSETLQLSNySTHP
  746-  776 (49.68/35.22)	LERFLGSVIMR...RHLqRIIQQETLQLIN.SNEP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21987 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
551
751










Molecular Recognition Features






MoRF SequenceStartStop




NANANA