<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21962

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMREWSFHMPSFSLRSPDVTSSSDVLKEGTYKRFPSIIKECFAPDVLDDDKAKETLEALNGVIQIRMLTQEIIPKRMRNYRILNGKIKFIVDKEFEAVLTPDNMGIDSRWWIIELKFLIQSASNKIFNDVKLSLHDEQISRLIDTIQKQYLSPPLKPIPERISSSMKRIGETLEPTSLSQTAKFCPLVNLYEYLHNYCLDLQLNILAQQAYYMRQTRWANNFDMIINDEDSVLKIYYWNYIKQALAAIRPSEMEVNHDIIEISVITEESDRHLLYSSNKALKRSHWYTDTKYVKLGALNDIRGINYPHKFLRVRWTGLKGAEASEWTVIDWEFDPTNLNIEHLMLSVTQRHAQAVINKFVDILKNDEKGFYTEDDFEIVGGNNELVHDLESSESPLSDEVARKYLHVQKLRVLLCGDFKDCYINIGIDIHSGRIFIEDEKQEIDSGM
Length446
PositionTail
OrganismRhizophagus sp. MUCL 43196
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
Aromaticity0.10
Grand average of hydropathy-0.376
Instability index48.03
Isoelectric point5.49
Molecular weight52015.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21962
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.61|      13|     110|     271|     297|       1
---------------------------------------------------------------------------
  232-  244 (26.15/18.78)	LKIYYW....NYIK.QAL
  280-  297 (15.46/18.05)	LKRSHWytdtKYVKlGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.74|      42|      48|     325|     372|       2
---------------------------------------------------------------------------
  329-  370 (73.54/61.32)	DWEFDPTNLNIEHLMLSVTQRHAQAVINKFVDILK......NDEKGFY
  374-  421 (66.21/37.62)	DFEIVGGNNELVHDLESSESPLSDEVARKYLHVQKlrvllcGDFKDCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.02|      48|      49|      61|     108|       3
---------------------------------------------------------------------------
   61-  108 (79.32/54.01)	VIQIRMLTQEIIPKRMRNYR..ILNGKIKFIVDKEFEAVLTPDNMGIDSR
  111-  160 (73.70/49.69)	IIELKFLIQSASNKIFNDVKlsLHDEQISRLIDTIQKQYLSPPLKPIPER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21962 with Med14 domain of Kingdom Fungi
Unable to open file!