<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21962
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MREWSFHMPSFSLRSPDVTSSSDVLKEGTYKRFPSIIKECFAPDVLDDDKAKETLEALNGVIQIRMLTQEIIPKRMRNYRILNGKIKFIVDKEFEAVLTPDNMGIDSRWWIIELKFLIQSASNKIFNDVKLSLHDEQISRLIDTIQKQYLSPPLKPIPERISSSMKRIGETLEPTSLSQTAKFCPLVNLYEYLHNYCLDLQLNILAQQAYYMRQTRWANNFDMIINDEDSVLKIYYWNYIKQALAAIRPSEMEVNHDIIEISVITEESDRHLLYSSNKALKRSHWYTDTKYVKLGALNDIRGINYPHKFLRVRWTGLKGAEASEWTVIDWEFDPTNLNIEHLMLSVTQRHAQAVINKFVDILKNDEKGFYTEDDFEIVGGNNELVHDLESSESPLSDEVARKYLHVQKLRVLLCGDFKDCYINIGIDIHSGRIFIEDEKQEIDSGM |
Length | 446 |
Position | Tail |
Organism | Rhizophagus sp. MUCL 43196 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina>
Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.376 |
Instability index | 48.03 |
Isoelectric point | 5.49 |
Molecular weight | 52015.81 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP21962
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.61| 13| 110| 271| 297| 1
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232- 244 (26.15/18.78) LKIYYW....NYIK.QAL
280- 297 (15.46/18.05) LKRSHWytdtKYVKlGAL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.74| 42| 48| 325| 372| 2
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329- 370 (73.54/61.32) DWEFDPTNLNIEHLMLSVTQRHAQAVINKFVDILK......NDEKGFY
374- 421 (66.21/37.62) DFEIVGGNNELVHDLESSESPLSDEVARKYLHVQKlrvllcGDFKDCY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 153.02| 48| 49| 61| 108| 3
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61- 108 (79.32/54.01) VIQIRMLTQEIIPKRMRNYR..ILNGKIKFIVDKEFEAVLTPDNMGIDSR
111- 160 (73.70/49.69) IIELKFLIQSASNKIFNDVKlsLHDEQISRLIDTIQKQYLSPPLKPIPER
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