<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21958

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDTNNWRPNQGPEANMDTSDWRGGLQHESRQRIVNKIMDTLKRHLPVSGQDGLHELRKIAQRFEEKIFTAATSQSDYLRKISLKMLTMETKSQGNIPPNQGGSSNKPPDPGLVIPPPVHNPGQQHPIPMPNPQGRQQLLSQNIQNNIASQSSSLGQPPIQNVGQNNPNMQNIPGQNSVGSTIGQNSNMQNMFAVSQRQIQGRQQVVPQQQQQQSQNSQQFLYQQQQQIQQQFLRQKLHQQQQQQQQQQQQQQQQQQQQNLLQSNQLQSSQPSVIQTSSVMQQSSMMQTSSLPSIQHNQQSNNVQQSAQSVLQQHSQVIRQQQPQQTSIIQQQQAPMNQQSILPPQQQQQQQIMGAQANATNMQHTQILGTQNNVGDLQQQQRLLAQQNNLSNLQQQQLINQQNNLSNIHQQLSNNVPGLQPQQVLGPQSGNSSMQTSQHSAHVLQQSQVPIQQQSQQNASNLLSSQAQQSQPQAPQQQLMPQIQSQPAQLQQQLGLQQQPNPLQRDMQQRLQNSGPLLHQPSVLDQQKQLYQSQRSLQDTSSTSLDSTAQTGQSSGGDWQEEVYQKIKSMKESYLPELNEMYQKIASKLQQHDSLPQQPKQDQLEKLKVFKMMLERIITFLQVSKSNVLPSYKEKLGSYEKQIINFINTNRPRKTMPGQFPPPHMHSMSQSQPQVTQGQSHENQMNSQLQTTNMQGSVATMQQNNMASMQHNSLSGVSTAQQSKMNSMQPSTNLDSGPGNAVNSLQQVSVSSLQQNPVSAPQQTNVNSLSSQAGVNVIQSNLNPLQPGSSMLQHQQLKQQQEQQMLQNQQLKQQYQQRQMMQRKQMLQQQQQQQQLHQTAKQQLPAQLPTHQIQQLHQMNDANDIKMRQGTAVKPGVFLQHQRSAYPHQQMKGSPFPVSSPQLLQATSPQIPQHSSPQVDQQNHLPSHTKVATPLQSANSPFGAPTPSSPLAPSPMPGDSEKPISGVSSISNAANIGYQQTGGAAAPAQSLAIGTPGMSASPLLAEFTGPDGAHGNALAPTSGKSTVTEQPIERLIKAVKSMSSKALSSAVSDIASVVSMNDRIAGSAPGNGSRAAVGEDLVAMTNCRLQARNFITQDGANGTRRMKRCTNATPLNFASSAGSMNDSIKQLTASEASDMDSTATSRFKRPRIEVANHSLLEEIREVNQRLIDTVVDISNEEVDPTAAAAAAEGTEGTIVKCSFNAVALSPSLKSQYASAQMSPIQPLRLLVPTNYPNCSPILLDKFPVESSKENEDLSVKAKSRFSISLRSLSQPMSLGEIARTWDVCARRVISEHAQQSGGGSFSSKYGTWENCLTT
Length1318
PositionTail
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.03
Grand average of hydropathy-0.843
Instability index73.14
Isoelectric point9.48
Molecular weight145483.50
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21958
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.96|      28|      30|     198|     227|       1
---------------------------------------------------------------------------
  198-  227 (46.07/14.61)	QIQGRQQvVpQQQQQQSQNSQ..QFLYQQQQQ
  244-  267 (43.34/ 8.48)	QQQQQQQ...QQQQQQQQN.....LLQSNQLQ
  804-  833 (42.55/ 8.17)	QMLQNQQ.L.KQQYQQRQMMQrkQMLQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.51|      26|      30|     347|     376|       2
---------------------------------------------------------------------------
  347-  376 (33.23/13.58)	QQQQQIMGAQANATNMqHTQIlgtQNNVGD
  393-  418 (39.28/ 8.73)	LQQQQLINQQNNLSNI.HQQL...SNNVPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.17|      20|      30|     694|     722|       3
---------------------------------------------------------------------------
  280-  299 (35.30/ 6.99)	MQ.QSSMMQTSSLPSIQHN........QQ
  694-  722 (25.86/13.10)	MQgSVATMQQNNMASMQHNslsgvstaQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.31|      24|      29|     445|     473|       6
---------------------------------------------------------------------------
  448-  478 (31.10/13.90)	QVPIQqqSQQNASNLLSsqaQQSQPQapQQQ
  779-  802 (37.21/ 7.89)	QSNLN..PLQPGSSMLQ...HQQLKQ..QQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.26|      12|      17|     899|     913|       8
---------------------------------------------------------------------------
  899-  913 (14.02/10.27)	SSPQLlqATSPqIPQ
  947-  958 (21.24/ 6.08)	PSSPL..APSP.MPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.59|      14|      17|     304|     320|       9
---------------------------------------------------------------------------
  308-  324 (23.41/11.46)	QSVLQQHSQVirqQQPQ
  521-  534 (24.19/ 6.11)	PSVLDQQKQL...YQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.97|      15|      19|      96|     110|      10
---------------------------------------------------------------------------
   96-  110 (32.15/13.20)	IPP...NQGGSSNKP.PDP
  114-  132 (24.82/ 8.39)	IPPpvhNPGQQHPIPmPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.44|      15|      39|     377|     391|      11
---------------------------------------------------------------------------
  377-  391 (25.74/ 6.95)	LQQQQRLLAQQNNLS
  490-  504 (25.35/ 6.70)	LQQQLGLQQQPNPLQ
  589-  603 (25.35/ 6.70)	LQQHDSLPQQPKQDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.06|      15|      16|    1036|    1050|      12
---------------------------------------------------------------------------
 1036- 1050 (23.37/16.13)	IKAVKSMSSKALSSA
 1054- 1068 (24.69/17.50)	IASVVSMNDRIAGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.48|      18|      24|    1084|    1107|      13
---------------------------------------------------------------------------
  998- 1015 (34.15/17.61)	MSASPLLA.EFTGPDGAHG
 1084- 1102 (30.32/33.93)	MTNCRLQArNFITQDGANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.77|      19|      23|     651|     670|      15
---------------------------------------------------------------------------
  651-  670 (34.78/21.48)	RPRKTmPGQFPPPHMHSMSQ
  672-  690 (34.99/16.71)	QPQVT.QGQSHENQMNSQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.97|      18|      23|    1106|    1123|      29
---------------------------------------------------------------------------
 1107- 1124 (32.58/22.07)	KRCTNATPLNFASSAGS.M
 1129- 1147 (24.39/14.46)	KQLTASEASDMDSTATSrF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      12|      54|     932|     945|      31
---------------------------------------------------------------------------
  932-  945 (17.15/14.56)	ATPLQSAnsPFGAP
  985-  996 (19.66/ 9.25)	AAPAQSL..AIGTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21958 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IINFINTNRPRKTMPGQFPPPHMHSMSQSQPQVTQGQSHENQMNSQLQTTNMQGSVATMQQNNMASMQHNSLSGVSTAQQSKMNSMQPSTNLDSGPGNAVNSLQQVSVSSLQQNPVSAPQQTNVNSLSSQAGVNVIQSNLNPLQPGSSMLQHQQLKQQQEQQMLQNQQLKQQYQQRQMMQRKQMLQQQQQQQQLHQTAKQQLPAQLPTHQIQQLHQMNDANDIKMRQGTAVKPGVFLQHQRSAYPHQQMKGSPFPVSSPQLLQATSPQIPQHSSPQVDQQNHLPSHTKVATPLQSANSPFGAPTPSSPLAPSPMPGDSEKPISGVSSISNA
2) KQLYQSQRSLQDTSSTSLDSTAQTGQSSGGDWQEE
3) MDTNNWRPNQGPEANMDTSDWRGGLQHESRQRIVNKIMDTLKRHLPVSGQDGLHELRKIAQRFEEKIFTAA
4) PQQTSIIQQQQAPMNQQSILPPQQQQQQQIMGAQANATNMQHTQILGTQNNVG
5) PSVIQTSSVMQQSSMMQTSSLPSIQHNQQSNNVQQS
6) QQQLINQQNNLSNIHQQLSNNVPGLQPQQVLGPQSGNSSMQTSQHSAHVLQQSQVPIQQQSQQNASNLLSSQAQQSQPQAPQQQLMPQIQSQPAQLQQQLGLQQQPNPLQRDMQQRLQNSGPLLHQPSVLDQ
7) RKISLKMLTMETKSQGNIPPNQGGSSNKPPDPGLVIPPPVHNPGQQHPIPMPNPQGRQQLLSQNIQNNIASQSSSLGQPPIQNVGQNNPNMQNIPGQNSVGSTIGQNSNMQNMFAVSQRQIQGRQQVVPQQQQQ
8) SASPLLAEFTGPDGAHGNALAPTSGKSTVTEQPIERL
643
528
1
323
271
395
79
999
973
562
71
375
306
526
212
1035










Molecular Recognition Features






MoRF SequenceStartStop




NANANA