<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21953

Description Mediator of RNA polymerase II transcription subunit 18 (Fragment)
SequenceMAMAVQNTTNPDQLQIVIHDVASNQFRSPSCDLVQNTRDYVNKCAPIYNLAIKGDWKEARNMLVADMRLARAAISQGWATLLHVAAEANQLHFVEELVKLLSEKDLELQDHKGNTAFCFAAAVGNVRIAEAMARRNTSLPTIRGGEGLTPLHMAALQGNTDMARYLYHDTVRIFDQGDWNLLFFLSINTDLALKMLQENPRLALARNENKETGLHVLARNPSAFTCQGTRYTNQLMLNSSRKNPTLALQLVRCLWDTLLSLDCTEIQMKKVISQPSQVIIIAAEVGNFEVLAELVRSYPDLIWEVDAKNRSIIHIAVLHRHAAIFNLIHEISSIRNFVATFEDADQNNLLHCAAKLAPPSQLNLVSGAAFQMMHELRWYEEVNKKMQPCFVEKRNSNGKTPRELFTEEHTELLTKAECWMKSMANSCMIVSTLIATEVFTAAFSIPRGTDDNNGNPNCNGVAFTIFAISDATALISSSISILIFLSMLTIARYGEDDFFKSLPLKLIYGLITLFISIASMMVAFSSAFFITYNHGLKWVPIMISVLALAPITLFTFLLFPLWSDIVYSAYFFRSIFRPSKHLRIADMECVVQGIIETQHVEALEILLQGLCGVQRERLRVHEICLKSGPHLGTVASEVRLLTVRHVGGAMRGAGAEQISVLVRTMVESKTSKNALRMFYTLGYKLDHELLRVGFSFNFHRGAQITVTVSSINKMLKLHATDEAVPVTPGIQMVEVTAPATAETYTEVASAVSSFCEYLAPLLHLSKPGISTGVVPTAAAAAASLMSDGGGTTL
Length793
PositionHead
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.08
Grand average of hydropathy0.150
Instability index34.53
Isoelectric point6.67
Molecular weight87860.79
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21953
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.72|       7|     122|      47|      56|       1
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   47-   56 ( 9.93/11.54)	IYNlaiKGDW
  173-  179 (15.79/ 7.73)	IFD...QGDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.67|      18|      35|     112|     129|       2
---------------------------------------------------------------------------
  112-  129 (31.90/20.60)	KGNTAFCFAAAVGNVRIA
  146-  163 (32.77/21.36)	EGLTPLHMAALQGNTDMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.25|      27|      36|     288|     316|       3
---------------------------------------------------------------------------
  288-  316 (40.88/38.83)	FEVLAEL..VRSYPDLIWEVDAKNrsIIHIA
  325-  353 (42.37/32.38)	FNLIHEIssIRNFVATFEDADQNN..LLHCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.99|      14|      15|     592|     605|       4
---------------------------------------------------------------------------
  592-  605 (22.66/17.99)	QGI..IETQHVEALEI
  608-  623 (18.33/13.02)	QGLcgVQRERLRVHEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.39|      29|     181|     498|     526|       6
---------------------------------------------------------------------------
  474-  506 (21.77/11.83)	...L..ISSSISI.......LIFLSmltiarygeddFFKSL..PLKL
  507-  543 (42.81/31.56)	IYGL..ITLFISIASMM...VAFSS...affitynhGLKWV..PIMI
  545-  580 (21.81/11.87)	VLALapITLFTFLLFPLwsdIVYSA..........yFFRSIfrPSK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.52|      14|      43|     191|     204|       7
---------------------------------------------------------------------------
  191-  204 (24.08/14.48)	LALKMLQENPRLAL
  235-  248 (24.44/14.80)	LMLNSSRKNPTLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      16|      17|     628|     644|       8
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  628-  644 (23.00/20.49)	GPHLGTVASEVRLLtVR
  648-  663 (26.98/18.46)	GAMRGAGAEQISVL.VR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21953 with Med18 domain of Kingdom Viridiplantae
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