<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21945

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceLGEMQRYHAGSCTSAVNNSTIGGPSARDTGRTDSSSLPANFPVSSRRQPPLTPYKLKCDKEPLNSRLGPPDYHPQTPNCPEETLTREYLQSGYRDTVEGIEESRETSLSQVLNFNKGIVLNCKEAIRRRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFRKKWIEGLSQQHKRLRSLTDLVPHVRRKSLLEVLIKNNVPLLRATWFIKVTYLNLVRSGSVSIPSGTADKTQLSCSELWTKDVIEYLQTLLDEFFSKNTSHNRDRSPQVPYTASLQHRNDQLLSVSDGEEPSLHFKWWYIVRLLQWHHAEGLLLPSLIIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRIIRDPAPGGSDLVDNSRRAYTTSALIEMLRYLILAAPETFVALDCFPLPSSVISHTINDGNFVLKATEAAGKIKNSSEDVVCLFRSKGFDAQYQSLAFDHVISCIQERVEDLKKAVSPGYPGQCLGKAAQALDKSLVLGDIHGAYKNLFEDLYDETVSESWVEKVSHCLRLSLKWFVTVNKSLIYSVFFLCEWATCDFRDFRTAPPCDVKFTGRKDLSQVHIAIRLLKMKLSDMQISPRQKSGSTRGRGVSYLAKCSSQQSNRNFVNNASKVKSSSRNMDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDMNVNVVDLERQKRHCRILKQLPGKFVHDALVESGISEGPRLTEALQVYLNERRLILRGSLWENHGNASNANISSLKQKHCTSSTKDRASMVLIDQGKSVLSNKISSKNAKDDNGVEELKTFISALLQLPKSSSNLSTTGLDESQGSVRKPIGSYSKIDPAEATPGCEECRKAKRQKLSEERSSFVQAPSPVLSDDEDTWWVKKGLKTSEPLKVDQPLKPIKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHVCDNKVSCPHHRTAMDGDTARSVDGIRSSDCEDIVSIGRALKQLRFVERKEITLWLMTVVRKLIEETEKTVGKVSQFGRPFATVDDKSSIRWKFGEDELSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNVLIPPRNVENQACDVGEAFLLSSLRRYENILAAADLIPEALSSIMHRAAAIIASNGRVSGSGSLAFARYLLKKYSNAVSVIEWEKNFKSTCDKRLASELESGRSVDGELGLPLGVPAGVEDPDDFFRQKISGGRLPSRVGSGMRDIVQRNVEEAFHYLYGKDRKLFAAGTPKGPAFEKWDNGYQIAQQIVMGLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPTLAKLPDFSAGSNHSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDTGTISNDVANNTSKIVVARTTKISAAVSALVVGAIICGVISLERIVTILRLKEGLDVVQFVRSTRSNSNGNVRSVGAFKVDSSVEVHVHWFRLLVGNCRTIYEGLVVDLLGEPSIVALSRMQRMLPLTLVFPPAYSIFAFVMWRPFVMNANIAVREDMNQLYQSLTVAISDAIKHLPFRDVCLRECQGLYDLMAADTSDAEFATLLELNGSDMHSKSVAFVPLRARHFLNAMIDCKMPLFIYTKDDGSRNSGHGESKIDFTDSESTLKDKLVDVLGALQPAKFHWQWVELRLLLNEQALIEKLEIRDLSLANAIQLSSPSSEKGAASENENNFIEIILTRLLVRPDAAPLFCELVHLFGKSLEDSMLLQAKWFLAGPDVLFGRKTIRQRLINIAENKRFSVKAQFSEPWGWCTPCKDTVTIKGDKKKVDSMPLEEGEVAEEGMDVKRSMKGFSQVSDSESSTSKQLHGTERALLELILPCIDQSSDESRNSFASDLIKQLNSIEQQIAVVTRGPSKPTASTPITEGQTNKVNSRKTIRGGSPGLARRSTPAPDSSPPSPAALRASISLRVQLLMRFLPILCSEGETSVRSPRFILANVLLGLLGSRVVHEDAMVNAMHYSPLKREVELPTEAAFVDSSVEGLFDRMLLILHGLLSSSPPSWLRSKPFSKTTNEPTREFSGFDREPLETLQNHLDNMQLPDTIRWRIQAAMPVLPLSMRRSFSCQPPTVPISALASLQPNATNSGFNSSSSTVPQRNLVPSSRTTASGKSKQQDNDSDVDPWTLLEDGAGSCPSASNTAIMGSSDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDSLEYENPSSGI
Length2274
PositionKinase
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index49.54
Isoelectric point8.75
Molecular weight251854.10
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21945
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.95|      58|     193|    1487|    1548|       1
---------------------------------------------------------------------------
 1487- 1548 (88.25/76.21)	VQFVRSTRSNSNGNVRSVGAFKvdsSVEVHVHW..FRLLVgNCRTIYEGLVVDLLGEPSIVALS
 1687- 1746 (90.70/64.47)	IDFTDSESTLKDKLVDVLGALQ...PAKFHWQWveLRLLL.NEQALIEKLEIRDLSLANAIQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.83|      35|     193|     625|     681|       2
---------------------------------------------------------------------------
  438-  481 (47.92/16.61)	NFVlkatEAAGKIKNSSEDV...VClfRSKGFDAQYqslAFDHVISC
  641-  678 (58.91/36.73)	NFV....NNASKVKSSSRNMdqnIC..SSAIFESPG...PLHDIIVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.73|      59|     528|     702|     762|       6
---------------------------------------------------------------------------
  704-  762 (102.19/66.68)	AGIFYPLAYVRQLIVSGIMDMNVN..VVDLERQ.KRHC..RILKQL.PGKFVHDALVESGISEG.P
 1181- 1233 (53.23/29.12)	......LAFARYLLKK..YSNAVS..VIEWEKNfKSTCdkRLASELeSGRSV.DG..ELGLPLGvP
 1234- 1291 (89.31/51.74)	AGVEDPDDFFRQKISGGRLPSRVGsgMRDI.VQ.RNVE..EAFHYL.YGK..DRKLFAAGTPKG.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.49|      86|     100|    1839|    1931|      11
---------------------------------------------------------------------------
 1839- 1931 (132.95/82.07)	GWCTPCKDTVTIKGDKKKVDSMPLEEGevAEEGMdVKRSmkgfSQVSDSESSTSKQLHGT...ERALLELILP..CID.QSSDES.RNSFASDLIKQLNS
 1942- 2034 (128.54/64.00)	GPSKPTASTPITEGQTNKVNSRKTIRG..GSPGL.ARRS....TPAPDSSPPSPAALRASislRVQLLMRFLPilCSEgETSVRSpRFILANVLLGLLGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.01|      63|    2096|      28|      99|      14
---------------------------------------------------------------------------
   28-   99 (97.46/79.68)	DTGR.TDSSSLPAnFPVSSRR....QPPLTPYKLKCDKEPLNSRLGppdYHPQTPNCPEetltREYLQSGyRDTVEG
 2129- 2196 (99.55/56.46)	DTIRwRIQAAMPV.LPLSMRRsfscQPPTVPISALASLQPNATNSG...FNSSSSTVPQ....RNLVPSS.RTTASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.71|      42|     611|     333|     378|      15
---------------------------------------------------------------------------
  333-  378 (65.20/50.26)	WVLRQLQEKQLLEIWQLLLPIvygfLEIVVLSQTYVR...TLAGVAL.RI
  923-  968 (61.50/37.23)	WVKKGLKTSEPLKVDQPLKPI....KQVTKTRQKTVRktqSLAQLAAsRI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21945 with Med12 domain of Kingdom Viridiplantae
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