<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21926

Description Mediator of RNA polymerase II transcription subunit 20 (Fragment)
SequenceRDKLSARAIKCVFLGYSRLQKGYKCYSPSTKRHYVRADALPIPYLSPTESSSLEIHNQDILQSSSSVHCQAELSSPLMSTCQSGTQEMGTSVCEYSLDSCPLSSTDPTPDPLPSSPSHDSDVSWSIALRKALNHPRWRQVMIVEMQVLEQSGTWELISLPSIKKAFGCRWVLAIKVAPNDTVDRFKARLVAKGYTQVYVLDYGDVFSPVAKITIIRLLLAMAAIRHWPLHQLDIKNAFLHGDLDEEIYMEQPPDFVAQGESGLVCKLCRSLYGLKQSLRAWFGKFSQVVQNFGMTRSEADHFVFYCHSSFGKFVYLVVYVDDIVIIENDDIKISQLKQYLFSHFQTKDLGHLKYFLGIEIAQSKEDIIISQRKYALDILQETSVSNCRPIDSPMDPNMKLMAPCVDHWATVLRILRYINKIPGQGLLYEDKGDTHIGQDLPLIDDLLQEKLLAKEISTEFVNSSNQLADIFTKSLRGPQIQIEYLPISSVEKSKQIMEEFIEIWKEVVSKKSLAGQFMHTEPNYGEYGLSDNYTSQHTAVQYAAALAQLIQSAHYPEALDRTHS
Length564
PositionHead
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.09
Grand average of hydropathy-0.206
Instability index49.73
Isoelectric point6.07
Molecular weight63869.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21926
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      13|      32|     124|     137|       1
---------------------------------------------------------------------------
  124-  137 (21.55/18.75)	WSI....ALRKALNhPRW
  154-  170 (21.67/12.73)	WELislpSIKKAFG.CRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.88|      22|      26|      58|      80|       2
---------------------------------------------------------------------------
   58-   80 (34.57/24.76)	QDILQS.SSSVhCQAELSS.PLMST
   82-  105 (31.30/17.05)	QSGTQEmGTSV.CEYSLDScPLSST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.40|      33|      35|     301|     335|       3
---------------------------------------------------------------------------
  268-  298 (23.89/11.37)	.....CRSlyglkqslraWFGKFSQ.........VVQ.NFGMTRSE
  301-  335 (50.66/42.45)	HFVFyCHS..........SFGKFVYLVvYVDDIVIIE.NDDIKISQ
  338-  371 (49.85/31.81)	QYLF.SHF..........QTKDLGHLK.YFLGIEIAQsKEDIIISQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.85|      12|      15|     476|     490|       6
---------------------------------------------------------------------------
  476-  487 (21.91/18.75)	RGPQIQIEYLPI
  492-  503 (19.94/ 7.11)	KSKQIMEEFIEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.05|      14|      15|     523|     537|       9
---------------------------------------------------------------------------
  523-  537 (21.35/21.74)	NYGEyGLSDNYTSQH
  541-  554 (22.70/15.87)	QYAA.ALAQLIQSAH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21926 with Med20 domain of Kingdom Viridiplantae
Unable to open file!