<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21921

Description Cyclin-dependent kinase E-1
SequenceMGDGSGSRWNRAEWVQQYDLLGKIGEGTYGLVFLARTKPPAPSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHRDKLNHSINQYTVKSLLWQLLNGLSYLHSNWMIHRDLKPSNILVMGEGEEHGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATSNPFQLDQLDKIFKVLGHPTLEKWPSLASLPHWQQDLQHIQGHKYDNAGLYNVVHLSPKSPAYDLLSKMLEYDPRKRLTAAQALEHDALVPCQLGEKIVNYPTRPVDTTTDLEGTTNLPPSQTVTGVSGSMAGAHGSNRSVPRPMNVVGMQRMPPQAMAAYNLTSQAAMGDGMNPGGISKQRGVPQAHQPQQLRRKEQTGMPGYPAQQKSRRMFLLEERPSEDRFGVNASVPKFMQAISGQSLPSILADLTLLQSKIGCILHWNLMLKC
Length507
PositionKinase
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.07
Grand average of hydropathy-0.317
Instability index42.01
Isoelectric point8.98
Molecular weight56550.44
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.24|      26|      28|     383|     408|       1
---------------------------------------------------------------------------
  383-  408 (48.65/25.51)	MNVVGM..QRMPPQAMAAYNLTSQAAMG
  411-  438 (43.59/22.23)	MNPGGIskQRGVPQAHQPQQLRRKEQTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.74|      26|      31|     302|     331|       2
---------------------------------------------------------------------------
  305-  331 (41.11/34.08)	SKMLEYdPRKRLTAAQALEHDA.LVPCQ
  334-  360 (41.63/21.55)	EKIVNY.PTRPVDTTTDLEGTTnLPPSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21921 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMGDGMNPGGISKQRGVPQAHQPQQLRRKEQTGMPGYPAQQKSRRMFLLEER
2) NYPTRPVDTTTDLEGTTNLPPSQTVTGVSGSMAGAHGSNRSVPRPMNVVGMQRMPPQ
406
338
457
394










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIAIKKFKQ
44
53