<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21920

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMAAELGQQTVELSTLVTRAAHDSYASLKELVDKCKSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQAIQFSILQFLFVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYALTEDQQKPALKKLDTLVRSKLLQLSIPKEFSDIKVSDGTAMLRVDGEFKVLITLGYRGHLSMWRILHLELLVGEKNKPVKLEELRRFVLGDDLERRMAAAENPFSVLYSVLHELCVSLVMDTVLRQVQVLRLGRWRDAIRFELISDGLGASSSSAQNPEGESDSSALRTPGLKIVYWLDFEKNAGASESGTCPFIKIEPGSDLQIKCLHSNFVIDPLTGKEAEFVLDQSCIDVERLLLRAICCNRYTRLLEIKRELVKNVQVRRTADDVVLQSQMGEPDIEYKQKDDKCRSKDSEGHEVLRVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALLECEEALNQGSISAAEVFISLRSKSILHLFSSIGRVLGLEVYEHGFNTVKIPKNVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGKDNLSGGDLNLLRIKKIDIGQMQVHEDEMNLSLVDWGKLRAVLPNAVCSNQTSGHEFFSDVRLENSIQIARGHPSGFSSLVDDVFGLEKGSSVLPFSVQNLSSSVNTSLPSQYGSVPMNLHSLKAGSPSPKWEGGIQMSQVNNVTKTSGATNHYSGSLFSSSSVKGPVQSSSVGSIPTGQGRNTAGKKLSASKSEQDLASLKSPHSVDISSSAAMDEEQLRVLSDTSNDALSGSRSSRLLSPPRPTSSRMSIPTSRPNGPQVESYKASGSSSCATTPALEPTVSYSTGEDVTSKNDKKSRKRTASDMLTLIPSLQGVENNPGISKRRKISDSSGCQLSLPQGAMSAEMIPKTEGYSYGSLIAEANRGNAPSSIYIAALLHVVRHCSLCVKHARLTSQMDALDISYVEEVGLRSASSNIWFRLPFARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRADEKSEELVTSSDTKTSGTKVASDTADKLSEQMRRAFKIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKMNLIFCPGSVAKINFWPYLYIYYIRCLYSVQFLEDFINGAEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQTGGYISSQGLMLGNSTTNVGQPTSGPGANTVMPTASGITNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLANSNNPNPSSGSQMMAANGNRINLPISAAMSRAGNQVASLNRMGNALAGSSNLALMSAVSIRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHSGLNVDENSESSSAFRSNIHYDRQHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPNVSFLSMNGSHGGRACWLRVDDWEKCKQRVARTVEVNGSSAADVSQGRLKLVADSVQRNLHMCIQGLRDGSGVTSSSGGT
Length1852
PositionTail
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.07
Grand average of hydropathy-0.171
Instability index42.56
Isoelectric point8.32
Molecular weight202148.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21920
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.74|      14|      16|    1426|    1440|       1
---------------------------------------------------------------------------
 1426- 1440 (23.56/18.15)	GQQAGGlANSNNPN.P
 1443- 1457 (23.18/12.62)	GSQMMA.ANGNRINlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.72|      16|      16|     795|     810|       2
---------------------------------------------------------------------------
  795-  810 (25.22/13.54)	DISSSAAMDEEQLRVL
  812-  827 (23.51/12.11)	DTSNDALSGSRSSRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.56|      69|     740|     284|     358|       3
---------------------------------------------------------------------------
  284-  355 (113.94/65.15)	LR..LGR.....WRDAIRFELISDGLGASSSSAQNPEGesdSSALRTPGLKIVYWLDFEKNAGASESGTC.PFIKIEPGS
 1022- 1090 (98.40/49.34)	LR..LGRpgcmyWDVKINDQHFRDLWELQKGSNNTPWG.........SGVRIANTSDIDSHIHYDPDGVVlSYQSVEVDS
 1111- 1158 (61.22/28.31)	MRklLGV.....RADEKSEELVT..................SSDTKTSGTKVAS....DTADKLSEQMRR.AF.KIE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.15|      17|      17|    1196|    1212|       4
---------------------------------------------------------------------------
 1181- 1192 (18.42/10.95)	..WESGKEG...CTMHV
 1196- 1212 (34.00/28.79)	QLWPHTKMNLIFCPGSV
 1216- 1232 (33.73/28.49)	NFWPYLYIYYIRCLYSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.87|      17|      17|     834|     850|       5
---------------------------------------------------------------------------
  830-  846 (30.85/18.00)	PRPTSSRMSIPTSRPNG
  847-  863 (29.02/16.44)	PQVESYKASGSSSCATT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.54|      13|      17|     595|     610|       6
---------------------------------------------------------------------------
  595-  610 (17.14/20.07)	DLNLlriKKIDIGQMQ
  615-  627 (23.40/15.90)	EMNL...SLVDWGKLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.46|      30|     740|     722|     754|       7
---------------------------------------------------------------------------
  723-  754 (47.79/32.33)	IQMSQVNNVtkTSGATNHYSGSLFSSS.......SVKGP
  755-  791 (43.66/19.45)	VQSSSVGSI..PTGQGRNTAGKKLSASkseqdlaSLKSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.08|      13|      17|     630|     646|       8
---------------------------------------------------------------------------
  630-  644 (18.11/11.98)	LPNAVcsNQTSGHEF
  650-  662 (20.97/ 9.79)	LENSI..QIARGHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.29|      50|     811|     967|    1021|      11
---------------------------------------------------------------------------
  967- 1021 (83.24/71.83)	HVVRHCSLCVKHARLTSQmdalDISYVEEVGLRSASSNIWFRLPFArGDSWQ...HIC
 1783- 1835 (86.05/59.04)	HGGRACWLRVDDWEKCKQ....RVARTVEVNGSSAADVSQGRLKLV.ADSVQrnlHMC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21920 with Med14 domain of Kingdom Viridiplantae
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