<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21917

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceMLLLRFAGRNMVLVGQVLEIPEKQLLGLGAPDFLPQTPNCPEEILTREYLLSGYRDTVEGLEEAREISLTQVQHFTKKVVLNCKEAIRKRLRAINESRAQKRKAGQVYGVALSGSQLARSGVFPELRPCGEDFQKKWIEGLSQPHKRLRTLADHVPHGYKRASLLDVLIRNNVPLLRATWFIKVTYLNQVRPGSVGISSGTADKIQLSRSDVWTKDIINYLQTLLDEFLSKNVSHSASHGRERSPQMSYTGSLQNKNDPLLSVSDGEGPSLHFRWWYIVRLLQWHHAEGLLHPSLVIDWVFNQLQEKELLEVWQLLLPIIYGFLETIVLSQTYVRTLAGLALRVIRDPAPGGSDLVDNSRRAYTTYALIEMLRYLILVVPDTFVALDCFPLPSSVISHTMNDGSFVLKSTEAAGKIKNSSDDFGHIISCIQKHTEDIAKAASPGYPGHCLAKVPKALDKALMLGDLRVAYKFLFEDLCGGTVSESWVAKVSPCLRLSLKWFGTVNTPLIYSVFFLCEWATCDFRDFRSTPPRDIKFTGRKDISQVHIAVRLLKMKTRDVKISLKQTNGIHRASHFAKNSSQRHNWNYVGNVSKLKSSSKSRSSSVIFESPGPLHDIIVCWIDQHVVHKGEGPKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMDVNVNVADREQWRRHYRILKQLPGCFIHDVLEESGIVEGPQLKEALQIYLNERRLILRGPLSEPHTNLSALKKKQYPASTKDEASAVPIDQRRTVTSTPISSKTAKDDANIEELRTAIVVLLQLPNCLSSLSTTGCDESDGSVRRPIGSRYSKIDPVEGTPGCEECSRAKRQKLSEERSSFVVGHSPVQSDEDDTWWMKKGVKSPEPLKVDQPQKSTKQVTKSRQKNVRKTHSLAQLAASRIEGSQGASTSHVCGNKVSCPHHKTAMDGDGQRSVDSIRTCHYGDVVSIGKALKQLRFVEKRAIAVWLLTAARQVIEEMEKNVGKVGQFGRPFPIADDRSSIQWKLGEDELSAILYLMDISDDLVSAVKFLLWLLPKVLNSPNSSIHSGRNVLMVPRKVENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMHRAATVVASNGRVSGSGALAFTRYLLKKYSNVASVIEWEKTFKTTCDARLSSELESGRSVDGELGFPLGVPAGVEDPDDFFRQKISGGRLPSRVGAGMRDIVQRNVEDAFHYLFGKDRKLYAAGTPKGPALEKWDNGYQIAQQIVMGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNIMSAANSLNYARCILQMHITCLCLLKEALGERQSHVFDIALATEASTALAGVFTPTKASRAQFQMSPEAHDISNANSNDMGNNSNKVVVAKTTKIAAAVSALLVGAIIYGVTSLERMVTVLRLKEGLDVVQFVRSTRSNSNGNARSVMGFKVDSSVEVHVHWFRLLVGNCRTICEGLVVELLGEPYIMALSRMQRMLPLNLVFPPAYSIFAFVKWWPFILKANVTVREDMNQIYQSLTMAITDAIKHLPFRDVCFRDCQGLYDLMAADASDSEFATLLEFNGSDMHLKSTAFVPLRSRLFLNAMIDCKMPQSIYTKDDGSRVSGAGKFTDSGSKLQDMLVHVLDTLQPAKFHWQWVALRLLLNEQALVEKLETHDMSLADAIQLSSPIPEKAATASENENNFVQILLTRLLVRPDAAPLFSELIHLFGRSLEDSMLLQAKWFLGGPDVLFGRKTIRQRLHNIAESKGLSVKTQFWEPWGWCSPSTDPLTIKGDKKKFDSMPLEEGEVVEEGMDLKKSVRGLSQVSDSESSSSNQQQVTERALIELLLPCIDQSSDESRNSFANDLVKQLSQIEQQITAVTGGSKPVGSAPPGVEGQPNKVNNRKNMRGGSASLARRPTVAVDSLPPSPAALRASMSLRSQLLLRFLPILCTDRDQSVRSMRQFLATVIFRLLGSRIVHEDADISVNAMPSLLRREAELSSEVASAAFVDSSSGSLFERLLLVLHGLLSSYPPSWLKPKPVTKTINEPTREFCGVDRDLLETLQNDLDRMQLPDTIRWHIQAAMPILIPSMRCSLSCQPPSVSNSALVCLQPIIPQRNSALSRVAANASGKSKQQDSDLEIDPWTLLEDGTGSYPLAGNTASIGSGDHVNIRAASWLKGAVRVRRKDLTYVGAVDDDS
Length2192
PositionKinase
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index47.72
Isoelectric point8.80
Molecular weight242839.84
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21917
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.60|      61|     244|    1578|    1643|       1
---------------------------------------------------------------------------
 1578- 1643 (94.58/78.50)	SDMHLKSTAFVPLRSRLFLNAMIDCkMPQSiytkDDGSRVSGAGKFTDSGSKLQDMLVHVLDTLQP
 1820- 1880 (99.02/67.30)	SDSESSSSNQQQVTERALIELLLPC.IDQS....SDESRNSFANDLVKQLSQIEQQITAVTGGSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.83|      13|     244|     598|     610|       2
---------------------------------------------------------------------------
  598-  610 (23.30/13.43)	SKSRSSSVIFESP
  838-  850 (24.53/14.56)	SEERSSFVVGHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.95|      32|     244|     751|     793|       3
---------------------------------------------------------------------------
  751-  793 (40.52/52.38)	PI.DQRrtvtsTPISSKTAKDdanieELrTAIVVLLQLPNCLSS
  997- 1029 (52.43/34.09)	PIaDDR.....SSIQWKLGED.....EL.SAILYLMDISDDLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.41|      48|     990|     461|     518|       4
---------------------------------------------------------------------------
  461-  518 (74.03/77.25)	LMLGDLRVAYKFLFEDLCGgtvsESWVAKVS...PCLRLSLkwfgtVNTPlIYSVFFLCEW
 1460- 1510 (83.37/56.32)	LLVGNCRTICEGLVVELLG....EPYIMALSrmqRMLPLNL.....VFPP.AYSIFAFVKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.58|      65|      68|    1235|    1299|       5
---------------------------------------------------------------------------
 1235- 1299 (111.67/57.99)	NGYQIAQQIVMGLIDC...IRQTGGAAQEG..DPSLVSSAVSAIVGSVGPTLAKMPDFSSGNNHSNIMSA
 1301- 1370 (100.90/51.77)	NSLNYARCILQMHITClclLKEALGERQSHvfDIALATEASTALAGVFTPTKASRAQFQMSPEAHDISNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.37|      56|     528|     643|     707|       6
---------------------------------------------------------------------------
  613-  677 (94.58/74.14)	LHDIIVCWIDQHVVHKG..EGPK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................rlhlfivelIRAGIFYPLAYVRQLIVSGIMDVNVNVADREQWRR
  682-  704 (16.28/13.12)	LKQLPGCFIHDVLEESGivEGPQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1169- 1203 (49.50/24.83)	.......................lkealqiylnerrlilrgplsephtnlsalkkkqypastkdeasavpidqrrtvtstpissktakddanieelrtaivvllqlpnclsslsttgcdesdgsvrrpigsryskidpvegtpgceecsrakrqklseerssfvvghspvqsdeddtwwmkkgvkspeplkvdqpqkstkqvtksrqknvrkthslaqlaasriegsqgastshvcgnkvscphhktamdgdgqrsvdsirtchygdvvsigkalkqlrfvekraiavwlltaarqvieemeknvgkvgqfgrpfpiaddrssiqwklgedelsailylmdisddlvsavkfllwllpkvlnspnssihsgrnvlmvprkvenqvcdvgeafllsslrryenilvaadlipealssamhraatvvasngrvsgsgalaftryllkkysnvasviewektfkttcdarlsselesgrsvdgelgfplgVPAGVEDPDDFFRQKISGGRLPSRVGAGMRDIVQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.03|      30|    1660|      69|      98|       8
---------------------------------------------------------------------------
   69-   98 (51.29/33.64)	LTQVQHF.TKKVVLNCKEAIRKRLRAINESR
 1731- 1761 (49.74/32.39)	LLQAKWFlGGPDVLFGRKTIRQRLHNIAESK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.57|      20|     956|     859|     878|      10
---------------------------------------------------------------------------
  859-  878 (39.88/23.17)	WWMKKGVKSP..EPLKVDQPQK
 1769- 1790 (38.68/22.24)	FWEPWGWCSPstDPLTIKGDKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.44|      22|     956|     253|     275|      11
---------------------------------------------------------------------------
  253-  275 (36.22/26.64)	LQNKNDPLLSVSDGEGPSLHfRW
 1212- 1233 (40.23/24.41)	LFGKDRKLYAAGTPKGPALE.KW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21917 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDDTWWMKKGVKSPEPLKVDQPQKSTKQVTKSRQKNVRKTHSLAQLAASRI
2) TAVTGGSKPVGSAPPGVEGQPNKVNNRKNMRGGSASLARRPTV
855
1872
905
1914










Molecular Recognition Features






MoRF SequenceStartStop




NANANA