<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21901

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMAQGDCELLLLKIILEDLKIKWDGPIKLYCDNKSAISIAQHDRTKYIEVDRHFIKEKLDNGLICTPYVPSQVFHNLNLLLHISDVSRRGQPAVEFVFAATKEAIFIHVIVSSKHIRILSTGDLEKVLKHSMESTCRLPVIVSPHGIRGSLTGCSPSDLVKQSYFRSSTKFRVSNGIIGLPCHVSQGVGCQLRGQNCYVEVSLGFPRSGTDNTLQPNKISVRNLPKLHVAESPVAGRSDHKGSPNHLLDYEKTFLYPAEAVLVPVLQTSLARSSLRSAGNVDCTEDPWTEINGTRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPSELEADADSLTCRQSMVSSGDQLESDGPKLGSKRSRTGVTESLSTATNIPVQDVYMSDFGSMEVNNSAITGVGNEPIGSYWDWEDDDRGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALVFSAPDCGDVNSSPGGVIDVSDQILLPVGFPSFDSFIPPPSAAMEECLNKSQDNLNTSMPLGPTNQTQMLYTREFDHIMKAEAMMTFAPEFGAVETPTCELSTTLFRSPYFPKSRKAESSNSSSNNYLYGAAPPSSPCAEGSEGKNGMAVNTKTGSGKHDASMSFHSKNYYTFVESRKEKNDKNPFTCNDNSIAKSEGIPPLSNIGSNAIVKSALRKMTEGTHEAEHFLLSAKTLLATDITCVMLQASMCRLRHILLSSGNLSVGLSRSTGVSFLNQLPSDPSATTDNISSKYDVKKKENIPIRIAGDIDGGMLDGHHNAPVGVWRTLGATKVVKPSNSPNMEVGPSFSHNSFNEEGILSYGQRKPLQELLDGIALLVQQAISFVDLALDADCGDGPYGLLALQEQWRRGFCCGPSMVHAGCGGTLASSHSLDIAGLELVDPLSADVHASTVISLLQSDIKTALKSAFPNLEGPLTVTDWCKGRNQLVDTGSVVDGISAESSINECRDSSEPMSPSQSSVGGSSSIKGRISSMMDSAKVDETSQRRSGQDLCSTESEQQPCSRLKPTLVALPFPSILVGYQDDWLKTSANSLQHWEKAPLEPYALQKPIMYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGTQMEIDSAKLPSCGFVLLDCPQSMKIESSNASLVGSVSDYFLSLSNGWDLTSYLKSLSKALRGLKIGSCFSTNPSEGSNSSCLVIYVVCPFPDPTAILQTVIESSVAIGSVVQQSDRERRSSLHSQVVKALSGLATVDEASASNILVLSGFSIPKLVLQIVTVDSIFRVTSPSVSELVILKETAFTVYSKARRISRGISSDFAQPSFSRSHSVLTQMPSPISGMWKDCVGPRMAGHSLPREGDIDASLRPGTWDSSWQPTRTGGLSCDPSRTGDIFLHDEIRYMFEPLFILAEPGSLENGISVIGSPTSESSKALADDSSGNYVQSTSTAGSVESASSTDGSGSDPKTPPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQILQQGCLILQSCDPGLAKPRDFVIARIGGFYELEYLEWQKAIYSVGVSEMKRWPLQLRKSMSDGMSATSNGSSLQQPDMGLIPERTLPSSPSPLYSPHTKSTGFMKGSLGQPAARKQLIGGHSMVDNSRGLLHWAQSISFVAVSMDHTLQLALPADSSTPGYIEGFTPVKSLGSTSSAYILIPSPSMRFLPPTVLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSILSVSLIDYYGGTNIPQEKIVRGINKQGGRSLGWEAKDFEIETHLVLESLAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1855
PositionKinase
OrganismMucuna pruriens (Velvet bean) (Dolichos pruriens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Mucuna.
Aromaticity0.07
Grand average of hydropathy-0.221
Instability index54.98
Isoelectric point5.52
Molecular weight200751.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21901
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     317.79|      73|      89|    1306|    1378|       1
---------------------------------------------------------------------------
  721-  770 (42.92/17.12)	.....SRSTGVSFLNQLPSDPS.ATTDNISSKYDvkKKENIPiRiAGDID.GGMLDG.......................................
 1306- 1378 (139.39/74.38)	FAQP.SFSRSHSVLTQMPSPIS.GMWKDCVGPRM..AGHSLP.R.EGDID.ASLRPGTWDSSWQPTRTGGL................SCDPSRTGD
 1395- 1465 (99.31/50.59)	LAEPgSLENGISVIGSPTSESSkALADDSSGNYV....QSTS.T.AGSVEsASSTDG...SGSDPKTPPSL................HCCYGWTED
 1468- 1520 (36.18/13.12)	.........................WLVCIWTDS..RGELL........D.CNIFPFGGISSRQDTK..GLqclfvqilqqgclilqSCDP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.14|      28|      31|      86|     116|       2
---------------------------------------------------------------------------
   81-  113 (33.20/29.06)	HISdvSrRGQpaVEFVFAATKEAIF.IHVIVSSK
  114-  144 (41.94/24.21)	HIRilS.TGD..LEKVLKHSMESTCrLPVIVSPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.45|      24|      24|     948|     971|       3
---------------------------------------------------------------------------
  948-  971 (42.50/22.63)	VDGISA.ESSINECRDSSEPMSPSQ
  974-  998 (35.95/17.95)	VGGSSSiKGRISSMMDSAKVDETSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.08|      12|      31|     422|     433|       4
---------------------------------------------------------------------------
  422-  433 (22.46/11.78)	QALLSEFGDFGD
  452-  463 (23.62/12.79)	QALVFSAPDCGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.70|      26|      31|     872|     897|       5
---------------------------------------------------------------------------
  843-  869 (32.48/14.77)	LDADCGdgpyGLLALQE...QWR.RGF.CCGP.
  872-  897 (45.55/23.64)	VHAGCG....GTLASSH...SLDIAGLELVDPL
  901-  929 (34.67/16.26)	VHASTV....ISLLQSDiktALKSAFPNLEGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.74|      31|      31|     336|     366|       6
---------------------------------------------------------------------------
  271-  299 (31.31/11.65)	....RSSLRSAGnvDCTEDPWTEINGTRTQ....NSY
  302-  327 (38.20/15.75)	SSNSNSSSISSL..SASSSD.....SDYKT....TGP
  336-  366 (51.81/23.87)	SLTCRQSMVSSG..DQLESDGPKLGSKRSR....TGV
  369-  399 (35.42/14.10)	SLS.TATNIPVQ..DVYMSD...FGSMEVNnsaiTGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.14|      22|      61|    1609|    1630|       7
---------------------------------------------------------------------------
 1609- 1630 (41.31/21.14)	GFMKG.SLGQPAARKQLIGGHSM
 1671- 1693 (35.83/17.37)	GFTPVkSLGSTSSAYILIPSPSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.12|      42|      94|    1147|    1189|       9
---------------------------------------------------------------------------
 1147- 1189 (68.97/44.10)	SLSNGwDLTSYLKS.LSK.ALRGLKIGSCFS.TNPSEGSNSSCLVI
 1217- 1252 (49.79/25.75)	QQSDR.ERRSSLHSqVVK.ALSGL........ATVDEASASNILVL
 1256- 1283 (24.36/ 8.42)	.............S.IPKlVLQIVTVDSIFRvTSPS....VSELVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.81|      27|      94|    1542|    1568|      10
---------------------------------------------------------------------------
 1542- 1568 (48.97/32.70)	LEWQKAIYSVGVSEMKRWPLQLRKSMS
 1638- 1664 (46.85/30.93)	LHWAQSISFVAVSMDHTLQLALPADSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.34|      24|      71|     490|     517|      11
---------------------------------------------------------------------------
  492-  515 (43.39/21.33)	PPPSAAMEECLNKSQDNLNTSMPL
  587-  610 (39.95/15.71)	PPSSPCAEGSEGKNGMAVNTKTGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.74|      20|      33|     517|     536|      12
---------------------------------------------------------------------------
  517-  536 (37.00/27.14)	PTNQ..TQMLYTREFDHIMKAE
  551-  572 (32.74/23.01)	PTCElsTTLFRSPYFPKSRKAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.29|      16|      33|     152|     170|      13
---------------------------------------------------------------------------
  152-  170 (25.13/21.05)	GCspsDLVKQS.YFRSSTKF
  188-  204 (26.16/13.10)	GC...QLRGQNcYVEVSLGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.51|      45|     797|     209|     265|      14
---------------------------------------------------------------------------
  209-  256 (77.98/42.20)	TDNTLQPNKisvRNLPKLHVAESP..VAGRSDH..KGSPNHLLDYEKTFLYP
 1008- 1056 (71.54/32.10)	TESEQQPCS...RLKPTLVALPFPsiLVGYQDDwlKTSANSLQHWEKAPLEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.05|       9|     123|    1065|    1074|      16
---------------------------------------------------------------------------
 1065- 1074 (16.75/13.72)	YhVVCPDIDP
 1190- 1198 (22.29/12.48)	Y.VVCPFPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.94|      10|      73|    1130|    1141|      17
---------------------------------------------------------------------------
 1130- 1141 (13.74/13.17)	IESSNAslVGSV
 1206- 1215 (18.20/ 9.67)	IESSVA..IGSV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21901 with Med13 domain of Kingdom Viridiplantae
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