<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP21884

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMHERNLSLAAKGKAKESVQWQLGWWDLSHSLEGTKRPAQWSKSSVIYTAHESEPQVLGRHFPSAQQFYLPNPPLPYPIEADPPTVLSLCPSDDWLFAYFPGKSGEGFGCIWHKEAQLDDWQVKECWTYPVGGGIVTAAWSYPHREWVVTDEGTSMRLPTLGPLAPVGTPLLLLVTESHQLLVFTVSTQTKPQQLGRTSLLQHFTPDTEPIGKIGGDKICVKAAIGLCYQDSVILVAMRSKLLPSQGAAQALQNAVDLGLSMDLSQSQPVDSPFSHEWELWGEEPTISVCEVRIEYKPGIKPVLNRPLPPIYNPGSLVDMVFYCPPPPRSAGPSSSGSGKPDSKTSASNVRTLHLAATFFDSDDYTSLPKSEIVSYTFLAPGNPASYWVLRGEHRRQSHTKVPCFLLPSISRGGLLAGFLDAGGLLPRRKSKSKETTTGAIEVLKLPDLSTHEDWESVPILSHIQAGTIDVPVSAALSPNETLVCGISSPLLGSHQSIQILPRRVSGETSLILTGHLHEDLSRHLVAAIRARYSPSDVIHALAVPTLPTEVTVNTLDKTFTSMEADSFGLMEIWTGELLGVATEVARMRKLERGPEQDLCAARWQTAHEMSSLGACCSAFDTCREGDSYDLDAVWQLLGLTGWVIEFVEKLLKECIFVGERPDEPTTPSLGGFKGTTLDSPIFLHLVHPYSLSRLHTAMEHVKRFHDQVSKLTAKGENSHIAKDYLLDITEGSGIDLQLLGPFLAEILQESKTLNAQDLRRSLASCGPVHSLQPQIRKVINKVLTSKAIDRARLFIKPSDLSDGIARLSLSEPAAPSGTLKDKNVDVVKKSALWRNKAASVCTRCGGRSEVAVGVQTGTDKTLSRWQTWEKAWQLRCVCGGLWCSTVYS
Length888
PositionTail
OrganismPolyporus brumalis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Polyporus.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index48.14
Isoelectric point6.33
Molecular weight97308.96
Publications
PubMed=30061923

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP21884
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1031.92|     257|     259|     359|     616|       1
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   28-  121 (37.41/12.90)	..........................................................................................................................................................SH.SLEGTKR.........PAQwSKSSVIYTAHESE.pqvLGRH....................FPSA...........QQF..YLPN........PPL..PYPIEAD..PPTvlslcpsddwlfayFPGKSGEGFGC..IWHKE........AQLDDWQ.............................
  123-  356 (274.13/144.57)	............KECWTYP.VGGGivtaawsYPHREWVVTDE...GTSMRLPT.LG......PLA.PVGtPLLLLVTESHQLLVfTVSTQTKPQQLGRTS.LLQ......HFTPDTEPI.GKI.GGDKICVKAAIGLCYQDSVIlVAMRSKLLPSQGAAQALQN.........AVD.LGLSM........D...LSQSqpvdspfshewelwgeeptiSVCEV..........RIE..YKPG.IKPVLNRPLP..PIYNP.....................................GSLVDMVFYCPPPPR.SAGPS..SSGSGKpdSKTSASNVRTLHLAA
  359-  616 (421.49/229.68)	FDS.DDYTSLPKSEIVSYTFLAPG.......NPASYWVLRGEHRRQSHTKVPCFLL......PSI.SRG.GLLAGFLDAGGLLP.RRKSKSKETTTGAIE.VLKLPDLSTHEDWESVPIlSHI.QAGTIDVPVSAALSPNETLV.CGISSPLLGSHQSIQILPR.........RVS.GETSLILTGHLHED...LSRH....................LVAAI..........RAR..YSPSDVIHALAVPTL..PTEVTVNTLDKT..............FTSMEADSFGLMEIWTGELLGVATEVARMRKLERGPE..QDLCAA..RWQTAHEMSSLGACC
  619-  878 (298.89/158.31)	FDTcREGDSYDLDAV..WQLLG...........LTGWVIEFVEKLLKE....CIFVgerpdePTTpSLG.GFKGTTLDSPIFLH.LVHPYSLSRLHTAMEhVKRFHDQVSKLTAKGEN..SHIaKDYLLDITEGS...........GIDLQLLGPFLA.EILQEsktlnaqdlR.....RSLASCGPVH.S...LQPQ....................IRKVInkvltskaidRARlfIKPSDLSDGIARLSLsePAAPSGTLKDK...................NVDVVKKSALWRNKAASVCTRCGGRSEVAVGVQtgTDKTLS..RWQTWEKAWQLRCVC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP21884 with Med16 domain of Kingdom Fungi
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